TheLaboratoryofBacterialPolysaccharidesThemissionofthisLaboratoryisunifiedaroundthefactthat:Mostallinvasivebacterialdiseasesintheyoungpediatricpopulationarecausedbybacterialspecieshavingpolysaccharidecapsules:HaemophilusinfluenzaeNeisseriameningitidisStreptococcuspneumoniaeStreptococcusagalactiae(GroupBStrep)第1页/共12页LicensedVaccinesforwhichtheLBPhasProductResponsibilityPolysaccharides:Pneumococcal23-valentMerckMeningococcal4-valentAventisPasteurTyphoidViAventisPasteurConjugates:Haemophilusinfluenzaetypeb(Hib)WyethAventisPasteurMerck(2)Pneumococcal7-valentWyethCombinationvaccines第2页/共12页CurrentRegulatoryActivitiesintheLaboratoryofBacterialPolysaccharidesOINDsupplementreview–over125activeINDsProductLicenseapplicationandsupplementreviewOver80submissionssinceJune2000MeetingsandconferencecallswithmanufacturersLotreleaseprotocolreviewandlotreleasetestingApproximately400protocolsperyearAssistintrainingofreviewersandinspectorsParticipateininspectionsofmanufacturingfacilitiesPresentationstoVRBPAC第3页/共12页MajoroutsidemissionrelatedactivitiesbyLaboratoryofBacterialPolysaccharidesPersonnelTemporaryconsultantstoCDC,PAHO,WHOandPATHHelpdraftWHOrequirementsforconjugatevaccinesReviewRedBookchaptersonpolysaccharideandconjugatevaccinesJournalreview–multiplejournalsGrantreviewforMeningitisResearchFoundationReviewofMilitaryInfectiousDiseaseResearchProgramOnorganizingcommitteesformajorworkshopsConsult/trainforeignlaboratoriesinQualityControl第4页/共12页ResearchintheLaboratoryofBacterialPolysaccharidesTheLBPisresponsiblefor:Conductingbasicandappliedresearchonproblemsrelatedtothepreparation,purity,stability,andimmunogenicityofinvestigationalandlicensedvaccinesforencapsulatedbacterialpathogens.Evaluatinghost-parasiteinteractionsforpathogenesisandprotectiveimmunity.第5页/共12页OrganizationoftheLaboratoryofBacterialPolysaccharidesCarlE.Frasch,Ph.DLaboratoryChiefPathogenicNeisseriaSectionMargaretCBash,MDMedicalOfficerLipopolysaccharideSectionChao-MingTsai,Ph.D.BiochemistPolysaccharideandConjugateVaccineQCLotReleaseChi-JenLee,Sc.D.BiochemistPolysaccharideImmunitySectionCarlE.Frasch,Ph.DMicrobiologistCellularImmunologySectionMustafaAkkoyunlu,MD,Ph.D.Immunologist第6页/共12页ResearchObjectives:PolysaccharideImmunitySectionConductsresearchtoevaluatetheabilityofpolysaccharideandconjugatevaccinestoinduceprotectiveimmunity.Studiesdifferentconjugationchemistriestoimproveconjugateyieldsandtoimprovetheimmuneresponsetonativepolysaccharideepitopes第7页/共12页ResearchObjectives:CellularImmunitySectionFocusesontheinitialphaseofpolysaccharidevaccine/encapsulatedbacteriainteractionwithhostimmunity.Seekstodefinetheinteractionofpolysaccharideswithtoll-likereceptors(TLRs)oninnatecells.Thebiologicaleventsresultingfromthisinteractionmayaffectthedevelopmentofadaptiveimmuneresponsesagainstpolysaccharides.Investigatestheroleof“Aproliferation-inducingligand”(APRIL)andBLymphocyteStimulator(BLyS)ininfantandadultimmuneresponsesagainstbacterialpolysaccharides.第8页/共12页ResearchObjectives:PathogenicNeisseriaSectionInvestigatesthePorBproteinsofNeisseriagonorrhoeaeandNeisseriameningitidis.StudiesthenaturalepidemiologyofPorvariationusingnovelmoleculartypingmethods EvaluatestheeffectsofPorvariationonhost-pathogeninteractionincludingimmuneresponsestoPor,structurefunctionrestrictionsonPor,andtransmissionpatternsIdentifiesthemechanismsofPorvariationthroughinvestigationofmixedinfections,diverseandclonalpopulations. 第9页/共12页ResearchObjectives:LipopolysaccharideSectionConductsresearchtoevaluatechemicallyorgeneticallydetoxifiedmeningococcalLPSboundtoproteinasapotentialvaccineforgroupBmeningococcaldisease.StudiesthegeneticsofLPSbiosynthesisinpathogenicandcommensalNeisseriaspeciesandcharacterizestheirLPSimmunochemically.第10页/共12页Thankyou第11页/共12页感谢您的观看！第12页/共12页
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