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《GUSTO I研究》PPT课件教案

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《GUSTO I研究》PPT课件教案AddtheauthorandtheaccompanyingtitleGUSTOI研究GUSTO-I:GlobalUtilizationofStreptokinaseandt-PAforOccludedcoronaryarteries-I-TRIALDESIGN-Design:Randomized,parallelgroupPatients:41,021patientswithAMI,<6hafteronsetofsymptomsFollowupandendpoint:Primaryendpointdeathat3...

《GUSTO I研究》PPT课件教案
AddtheauthorandtheaccompanyingtitleGUSTOI研究GUSTO-I:GlobalUtilizationofStreptokinaseandt-PAforOccludedcoronaryarteries-I-TRIALDESIGN-Design:Randomized,parallelgroupPatients:41,021patientswithAMI,<6hafteronsetofsymptomsFollowupandendpoint:Primaryendpointdeathat30daysTreatment:Fourthrombolyticstrategiescompared:Streptokinase(SK)(1.5millionUover60min)andSCheparin(12,500Utwicedaily)SK(1.5millionUover60min)andIVheparin(bolus5000Uthen1000U/h)IVt-PA(1mg/kgover60min,10%bolus)andSK(1millionUover60min)andIVheparin(bolus5000Uthen1000U/h)Acceleratedt-PA(accelerateddoset-PAadministeredasbolus15mg,0.75mg/kgover30min(max50mg)and0.5mg/kgover1h(max35mg))andIVheparin(bolus5000Uthen1000U/h)GUSTO-I:GlobalUtilizationofStreptokinaseandt-PAforOccludedcoronaryarteries-I-RESULTS-Significantreductionin30-daymortalitywithacceleratedt-PAcomparedwiththestreptokinase(SK)andcombinationstrategiesNosignificantdifferencebetweencombinationstrategyandthetwoSKstrategies(P=0.352),orbetweenthetwoSKstrategies(P=0.731)Significantexcessofhemorrhagicstrokeforacceleratedt-PA(P=0.03)andcombinationstrategy(P<0.001),comparedwiththetwoSK-onlystrategiesHowever,combinedendpointofdeathordisablingstrokesignificantlylowerwithacceleratedt-PAthanwithSK-onlystrategies(6.9%versus7.8%;P=0.006)GUSTO-I:GlobalUtilizationofStreptokinaseandt-PAforOccludedcoronaryarteries-I-RESULTScontinued-TheGUSTOInvestigators.NEnglJMed1993;329:673–82.Thirty-daymortalityandstrokeinthefourtreatmentgroupsDaysafterrandomization001020302648SK+IVheparinSK+SCheparint-PA+SK+IVheparinAcceleratedt-PAMortality(%)GUSTO-I:GlobalUtilizationofStreptokinaseandt-PAforOccludedcoronaryarteries-I-RESULTScontinued-TheGUSTOInvestigators.NEnglJMed1993;–329:67382.Thirty-daymortalityandstrokeinthefourtreatmentgroupsMortality(%)Stroke(%)SK+IVheparinSK+SCheparint-PA+SK+IVheparinAcceleratedt-PA0.540.490.940.727.47.27.06.3Comparisonwithacceleratedt-PA*P0.0030.0090.04*P=0.001foracceleratedt-PAcomparedwithbothSKstrategiesAddtheauthorandtheaccompanyingtitle生活图标元素商务图标元素商务图标元素商务图标元素商务图标元素
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