USP滴定液（翻译）

⒈Ceric Sulfate, Tenth-Normal (0.1 N) Ce(SO4)2, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及 标准 excel标准偏差excel标准偏差函数exl标准差函数国标检验抽样标准表免费下载红头文件格式标准下载 操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 332.24 33.22 g in 1000 mL Use commercially available volumetric standard solution. Standardize the solution as follows. 硫酸铈滴定液（0.1N） 使用外购滴定液。按如下方法标定浓度： Accurately weigh about 0.2 g of sodium oxalate, primary standard, dried according to the instructions on its label, and dissolve in 75 mL of water. Add, with stirring, 2 mL of sulfuric acid that has previously been mixed with 5 mL of water, mix well, add 10 mL of hydrochloric acid, and heat to between 70 and 75. Titrate with 0.1 N ceric sulfate to a permanent slight yellow color. Each 6.700 mg of sodium oxalate is equivalent to 1 mL of 0.1 N ceric sulfate. 精确称量0.2g基准草酸钠（按标签说明干燥），使其溶解在75ml水中。边摇边加入预先混合的2ml硫酸与5ml水的混合溶液中，混匀后，加10ml盐酸，加热至70～75℃，用0.1N硫酸铈滴定液滴定至持久淡黄色。1ml0.1N硫酸铈滴定液相当于6.700mg草酸钠。 ⒉Edetate Disodium, Twentieth-Molar (0.05 M) C10H14N2Na2O8·2H2O, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 372.24 18.61 g in 1000 mL Dissolve 18.6 g of edetate disodium in water to make 1000 mL, and standardize the solution as follows. 称取18.6EDTA-2Na溶于适量水，并用水稀释至1000ml。并按下述方法标定： Accurately weigh about 200 mg of chelometric standard calcium carbonate, previously dried at 110 for 2 hours and cooled in a desiccator, transfer to a 400-mL beaker, add 10 mL of water, and swirl to form a slurry. Cover the beaker with a watch glass, and introduce 2 mL of diluted hydrochloric acid from a pipet inserted between the lip of the beaker and the edge of the watch glass. Swirl the contents of the beaker to dissolve the calcium carbonate. Wash down the sides of the beaker, the outer surface of the pipet, and the watch glass with water, and dilute with water to about 100 mL. While stirring the solution, preferably with a magnetic stirrer, add about 30 mL of the edetate disodium solution from a 50-mL buret. Add 15 mL of sodium hydroxide TS and 300 mg of hydroxy naphthol blue, and continue the titration with the edetate disodium solution to a blue endpoint. EDTA-2Na滴定液（0.05M）：精密称取在110℃干燥2小时并在干燥器中放冷却的基准碳酸钙约200mg，于一400ml烧杯中，加10ml水，轻摇使成混悬液。用 表 关于同志近三年现实表现材料材料类招标技术评分表图表与交易pdf视力表打印pdf用图表说话 pdf 面皿盖住烧杯，从烧杯与表面皿之间用移液管加入2ml稀盐酸。轻摇内容物使碳酸钙溶解。用水冲洗烧杯内壁、移液管外表面及表面皿，并用水稀释至约100ml。滴定过程中不断的振摇溶液（最好使用电磁搅拌器），从一50ml的滴定管加入约30mlEDTA-2Na滴定液后，加入15ml氢氧化钠试液和300mg的羟基萘酚蓝，继续用EDTA-2Na滴定液滴定至蓝色即为终点。1ml 0.05M EDTA-2Na相当于100.09mg的碳酸钙。 ⒊Ferrous Ammonium Sulfate, Tenth-Normal (0.1 N) Fe(NH4)2(SO4)2·6H2O, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 392.14 39.21 g in 1000 mL Dissolve 40 g of ferrous ammonium sulfate in a previously cooled mixture of 40 mL of sulfuric acid and 200 mL of water, dilute with water to 1000 mL, and mix. On the day of use, standardize the solution as follows. 硫酸亚铁铵滴定液（0.1N）：取六水合硫酸亚铁铵40g，溶于预先冷却的40ml硫酸和200ml水的混合液中，加水稀释成1000ml，摇匀。本液使用当天，依下标定浓度： Accurately measure 25 to 30 mL of the solution into a flask, add 2 drops of orthophenanthroline TS, and titrate with 0.1 N ceric sulfate VS until the red color is changed to pale blue. 精密移取25～30ml的硫酸亚铁铵滴定液（0.1N）溶液至烧瓶中，加入2ml的邻二氮菲指示液，用0.1N的硫酸铈滴定液滴定使溶液由红色变为淡蓝色。 ⒋Hydrochloric Acid, Normal (1 N) HCl, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 36.46 36.46 g in 1000 mL Dilute 85 mL of hydrochloric acid with water to 1000 mL. Standardize the solution as follows. 盐酸滴定液（1. 0N）：取盐酸85ml，加水适量稀释成1000ml。标定方法如下： Accurately weigh about 5.0 g of tromethamine, previously dried at 105 for 3 hours. Dissolve in 50 mL of water, and add 2 drops of bromocresol green TS. Titrate with 1 N hydrochloric acid to a pale yellow endpoint. Each 121.14 mg of tromethamine is equivalent to 1 mL of 1 N hydrochloric acid. 精密称定约5.0g的氨基丁三醇（预先在105℃干燥3小时），加50ml水溶解，加入2滴溴甲酚绿试液。用1N盐酸滴定至淡黄色。每1ml的1N盐酸相当于121.14mg的氨基丁三醇。 ⒌Hydrochloric Acid, Half-Normal (0.5 N) HCl, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 36.46 18.23 g in 1000 mL To a 1000-mL volumetric flask containing 40 mL of water slowly add 43 mL of hydrochloric acid. Cool, and add water to volume. Standardize the solution as follows. 向内含40ml水的1000ml量瓶中加入43ml盐酸，放冷，加水稀释至刻度。依下法标定浓度： Accurately weigh about 2.5 g of tromethamine, previously dried at 105 for 3 hours. Proceed as directed under Hydrochloric Acid, Normal (1 N), beginning with “Dissolve in 50 mL of water.” 准确称取约2.5g的氨基丁三醇（预先在105℃干燥3小时），自溶于50ml水中起，依1N盐酸滴定液项下操作。 ⒍Iodine, Tenth-Normal (0.1 N) I, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 126.90 12.69 g in 1000 mL Dissolve about 14 g of iodine in a solution of 36 g of potassium iodide in 100 mL of water, add 3 drops of hydrochloric acid, dilute with water to 1000 mL, and standardize the solution as follows. 称取14g碘溶于100ml 36%碘化钾溶液中，加3滴盐酸，用水稀释至1000ml。依下法标定浓度： Transfer 25.0 mL of the iodine solution to a 250-mL flask, dilute with water to 100 mL, add 1 mL of 1 N hydrochloric acid, swirl gently to mix, and titrate with 0.1 N sodium thiosulfate VS until the solution has a pale yellow color. Add 2 mL of starch TS and continue titrating until the solution is colorless. Preserve in amber-colored, glass-stoppered bottles. 移取25.0ml碘滴定液于250ml烧瓶中，用水稀释至100ml，加1ml1N盐酸，轻摇混合均匀，用0.1N硫代硫酸钠滴定液滴定至淡黄色。加2ml淀粉溶液，继续滴定至无色。（贮存于棕色密闭瓶中） ⒎Iodine, Twentieth-Normal (0.05 N) I, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 126.90 6.33 g in 1000 mL Dissolve about 6.5 g of iodine in a solution of 18 g of potassium iodide in 100 mL of water, add 3 drops of hydrochloric acid, dilute with water to 1000 mL, and standardize the solution as follows. 称取6.5g碘溶于18%碘化钾溶液100ml中，加3滴盐酸，用水稀释至1000ml。依下法标定： Transfer 50.0 mL of the iodine solution to a 250-mL flask, dilute with water to 100 mL, add 1 mL of 1 N hydrochloric acid, swirl gently to mix, and titrate with 0.1 N sodium thiosulfate VS until the solution has a pale yellow color. Add 2 mL of starch TS, and continue titrating until the solution is colorless. 移取50.0ml碘滴定液于250ml烧瓶中，用水稀释至100ml，加1ml1N盐酸，轻摇混合，用0.1N硫代硫酸钠滴定液滴定至溶液变为淡黄色。加2ml淀粉溶液，继续滴定至无色。 ⒏Perchloric Acid, Tenth-Normal (0.1 N) in Glacial Acetic Acid HClO4, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 100.46 10.05 g in 1000 mL note—Where called for in the tests and assays, this volumetric solution is specified as “0.1 N perchloric acid.” Thus, where 0.1 N or other strength of this volumetric solution is specified, the solution in glacial acetic acid is to be used, unless the words “in dioxane” are stated. [See also Perchloric Acid, Tenth-Normal (0.1 N) in Dioxane.] Mix 8.5 mL of perchloric acid with 500 mL of glacial acetic acid and 21 mL of acetic anhydride, cool, and add glacial acetic acid to make 1000 mL. Alternatively, the solution may be prepared as follows. Mix 11 mL of 60 percent perchloric acid with 500 mL of glacial acetic acid and 30 mL of acetic anhydride, cool, and add glacial acetic acid to make 1000 mL. Allow the prepared solution to stand for 1 day for the excess acetic anhydride to be combined, and determine the water content by Method I (see Water Determination 921 ), except to use a test specimen of about 5 g of the 0.1 N perchloric acid that is expected to contain approximately 1 mg of water and the Reagent (see Reagent under Method Ia in Water Determination 921 ) diluted such that 1 mL is equivalent to about 1 to 2 mg of water. If the water content exceeds 0.5%, add more acetic anhydride. If the solution contains no titratable water, add sufficient water to obtain a content of between 0.02% and 0.5% of water. Allow the solution to stand for 1 day, and again titrate the water content. The solution so obtained contains between 0.02% and 0.5% of water, indicating freedom from acetic anhydride. Standardize the solution as follows. 取8.5ml高氯酸加入500ml冰醋酸与21ml醋酸酐的混合溶液中，放冷后，用冰醋酸稀释至1000ml。或将11ml60%高氯酸与500ml冰醋酸和30ml醋酸酐混合液混合，放冷，用冰醋酸稀释至刻度。将配制好的溶液放置1天，使过量的醋酸酐与水结合，依Method I (see Water Determination 921 )测定含水量， 测定5g供试品要求0.1N高氯酸含有约1mg水，卡尔费休滴定液浓度1～2mg/ml。如果含水量超过0.5%，加适量醋酸酐；如含水量太低，加适量水使含水量在0.02%～0.5%之间。放置一天后再测定含水量，若溶液含水量在0.02%～0.5%范围内，标明无游离醋酸酐。则可依下法标定： Accurately weigh about 700 mg of potassium biphthalate, previously crushed lightly and dried at 120 for 2 hours, and dissolve it in 50 mL of glacial acetic acid in a 250-mL flask. Add 2 drops of crystal violet TS, and titrate with the perchloric acid solution until the violet color changes to blue-green. Deduct the volume of the perchloric acid consumed by 50 mL of the glacial acetic acid. Each 20.42 mg of potassium biphthalate is equivalent to 1 mL of 0.1 N perchloric acid. 精确称取约700mg邻苯二甲酸氢钾（预先研碎并在120℃干燥2h）于250ml烧瓶中，加50ml冰醋酸，加2滴结晶紫试液，用0.1N高氯酸滴定至溶液由紫色变为蓝绿色。用空白溶液校正。每1ml0.1N高氯酸滴定液相当于20.42mg邻苯二甲酸氢钾。 ⒐Potassium Permanganate, Tenth-Normal (0.1 N) KMnO4, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 158.03 3.161 g in 1000 mL Dissolve about 3.3 g of potassium permanganate in 1000 mL of water in a flask, and boil the solution for about 15 minutes. Insert the stopper in the flask, allow it to stand for at least 2 days, and filter through a fine-porosity, sintered-glass crucible. If necessary, the bottom of the sintered-glass crucible may be lined with a pledget of glass wool. Standardize the solution as follows. 取3.3g高锰酸钾，用适量水溶解，并用水稀释至1000ml。将溶液煮沸15min，塞紧塞子，静置至少2天后，用垂熔玻璃漏斗过滤（如有必要，垂熔玻璃漏斗底部垫玻璃棉）。依下述方法标定： Accurately weigh about 200 mg of sodium oxalate, dried according to the instructions on its label, and dissolve it in 250 mL of water. Add 7 mL of sulfuric acid, heat to about 70, and then slowly add the permanganate solution from a buret, with constant stirring, until a pale pink color, which persists for 15 seconds, is produced. The temperature at the conclusion of the titration should be not less than 60. Calculate the normality. Each 6.700 mg of sodium oxalate is equivalent to 1 mL of 0.1 N potassium permanganate. 精确称取200mg草酸钠（依标签说明干燥），加200ml水溶解，加7ml硫酸，加热至70℃后，从滴定管中缓慢滴加高锰酸钾滴定液，并不断的搅拌，直至溶液变为淡粉红色，并持续15s不消失，即为终点。滴定结束后溶液的温度应不低于60℃.计算当量浓度，每ml0.1N高锰酸钾滴定液相当于6.700mg草酸钠。 Since potassium permanganate is reduced on contact with organic substances such as rubber, the solution must be handled in apparatus entirely of glass or other suitably inert material. It should be frequently restandardized. Store in glass-stoppered, amber-colored bottles. 因为高锰酸钾滴定液与有机物质接触浓度会下降，所以该滴定液必须保存在玻璃或其他适宜的惰性材料容器中，该滴定液应经常地复标。贮存于密塞的棕色瓶中。 ⒑Silver Nitrate, Tenth-Normal (0.1 N) AgNO3, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 169.87 16.99 g in 1000 mL Dissolve about 17.5 g of silver nitrate in 1000 mL of water, and standardize the solution as follows. 称取17.5g硝酸银，溶于适量水，并用水稀释至1000ml。 Transfer about 100 mg, accurately weighed, of reagent-grade sodium chloride, previously dried at 110 for 2 hours, to a 150-mL beaker, dissolve in 5 mL of water, and add 5 mL of acetic acid, 50 mL of methanol, and about 0.5 mL of eosin Y TS. Stir, preferably with a magnetic stirrer, and titrate with the silver nitrate solution. 称取100mg氯化钠（预先在110℃干燥2h）于150ml烧杯中，用5ml水溶解后，加5ml醋酸，50ml甲醇和0.5ml曙红Y试液，在磁力搅拌下，用硝酸银滴定液滴定。 ⒒Sodium Hydroxide, Normal (1 N) NaOH, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 40.00 40.00 g in 1000 mL Dissolve 162 g of sodium hydroxide in 150 mL of carbon dioxide-free water, cool the solution to room temperature, and filter through hardened filter paper. Transfer 54.5 mL of the clear filtrate to a tight, polyolefin container, and dilute with carbon dioxide-free water to 1000 mL. 将162g氢氧化钠溶于150ml去二氧化碳水中，放冷至室温，用硬质滤纸过滤。移取54.5ml澄清滤液于一密封良好的聚乙烯塑料瓶中，用去二氧化碳水稀释至1000ml。 Accurately weigh about 5 g of potassium biphthalate, previously crushed lightly and dried at 120 for 2 hours, and dissolve in 75 mL of carbon dioxide-free water. Add 2 drops of phenolphthalein TS, and titrate with the sodium hydroxide solution to the production of a permanent pink color. Each 204.23 mg of potassium biphthalate is equivalent to 1 mL of 1 N sodium hydroxide. 精确称取约5g邻苯二甲酸氢钾（预先研细，并在120℃干燥2h），将其溶解于75ml去二氧化碳水中，加2滴酚酞试液，用1N氢氧化钠滴定液滴定至持久粉红色。每1ml1N氢氧化钠滴定液相当于204.23mg邻苯二甲酸氢钾。 ⒓Sodium Thiosulfate, Tenth-Normal (0.1 N) Na2S2O3·5H2O, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 248.19 24.82 g in 1000 mL Dissolve about 26 g of sodium thiosulfate and 200 mg of sodium carbonate in 1000 mL of recently boiled and cooled water. Standardize the solution as follows. 称取26g硫代硫酸钠与200mg碳酸钠，用适量新沸冷水溶解，并稀释至1000ml。依下述方法标定： Accurately weigh about 210 mg of primary standard potassium dichromate, previously pulverized and dried according to the instructions on its label, if necessary, and dissolve in 100 mL of water in a glass-stoppered, 500-mL flask. Swirl to dissolve the solid, remove the stopper, and quickly add 3 g of potassium iodide, 2 g of sodium bicarbonate, and 5 mL of hydrochloric acid. Insert the stopper gently in the flask, swirl to mix, and allow to stand in the dark for exactly 10 minutes. Rinse the stopper and the inner walls of the flask with water, and titrate the liberated iodine with the sodium thiosulfate solution until the solution is yellowish green in color. Add 3 mL of starch TS, and continue the titration until the blue color is discharged. Perform a blank determination. Restandardize the solution as frequently as supported by laboratory stability data. In the absence of such data, restandardize the solution weekly. 硫代硫酸钠滴定液（0.1N）：准确称取约210mg基准重铬酸钾（预先研细并按标签上的说明干燥）于一500ml碘量瓶中，用100ml的水溶解。振摇使溶解，迅速加3g碘化钾，2g碳酸氢钠 ，和5ml盐酸。塞上塞子，振摇混合均匀，暗处放置10分钟。用水淋洗塞子和瓶壁，用0.1N的硫代硫酸钠滴定液滴定游离碘，直到溶液呈黄绿色，加入3ml淀粉试液，继续滴定直到蓝色消失。每1ml的硫代硫酸钠滴定液（0.1N）相当于4.904mg的重铬酸钾。 ⒔Sulfuric Acid, Normal (1 N) H2SO4, INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET INCLUDEPICTURE "mk:@MSITStore:F:\\新建文件夹\\各国药典及标准操作规程\\usp\\usp32_nf27_2009.chm::/pub/data/images/chars/blank.gif" \* MERGEFORMATINET 98.08 49.04 g in 1000 mL Add slowly, with stirring, 30 mL of sulfuric acid to about 1020 mL of water, allow to cool to 25, and determine the normality by titration against tromethamine as described under Hydrochloric Acid, Normal (1 N). 硫酸滴定液（1N）：将30ml硫酸缓缓加入约1020ml水中，放冷至室温，依下述方法标定。 准确称取约5.0g氨基丁三醇（105℃干燥3h），将其溶于50ml中，加2滴溴甲酚绿试液。用1N硫酸滴定至淡黄色。每1ml 1N的硫酸相当于121.14mg的氨基丁三醇。