BN12 synaptic transmissionbn12突触transmissionpptSynapticTransmissionLesson12SynapsesCommunicationb/nneuronsElectricalElectrotonicconductionChemicalLigand/receptor~ElectricalSynapsesTightjunctionsConnexonsPassivecurrent&largermolecules(e.g.,ATP)SynchronousactivityBreathingHormonereleasefromhypothalamus~Synap...
SynapticTransmissionLesson12SynapsesCommunicationb/nneuronsElectricalElectrotonicconductionChemicalLigand/receptor~ElectricalSynapsesTightjunctionsConnexonsPassivecurrent&largermolecules(e.g.,ATP)SynchronousactivityBreathingHormonereleasefromhypothalamus~SynapticEventsActionPotentialreachesaxonterminalChemicalsubstancereleasedNeurotransmitter(NT)DiffusesacrosssynapseBindstoreceptorproteinEPSPorIPSP~1.Precursortransport2.NTsynthesis3.Storage4.Release5.Activation6.Termination~SynapticTransmissionModelPresynapticAxonTerminalPostsynapticMembraneTerminalButtonDendriticSpine1.PrecursorTransportE2.SynthesisEnzymes&cofactors~3.StorageESynapseTerminalButtonDendriticSpine3.StorageInvesiclesSynapseCa++AP4.ReleaseviaexocytosisdiffusionExocytosis:MembraneFusionCa2+influx2dmessengerCa2+-CalmodulinSNAPssoluble-NSF-attachmentproteinsSNAREsSNAPreceptors~5.ActivationNTbindstoreceptorActivationNTbindstopostsynapticreceptoropensionchannelEPSPNa+intocellorIPSPK+outofcell~6.Termination4BasicmethodsDiffusionEnzymaticdegradationPresynapticreuptakeactivetransportAutoreceptors~6.TerminationautoreceptorsAAutoreceptorsOnpresynapticterminalBindsNTsameaspostsynapticreceptorsdifferentreceptorsubtypeDecreasesNTrelease&synthesis~TerminationMusthavediscretesignalWhatifionchannelscontinuallyopen?ionsmovetowardequilibriummembranenolongerpolarizednoEPSPsorIPSPsDisruptsneuralcommunicationTermination--->neuronrepolarizes~AxoaxonicSynapsesModulationofNTrelease*viaorCa2+influxPresynapticFacilitationIncreasesNTreleasePresynapticInhibitiondecreasesNTreleaseViamodulationofEmCa2+,K+,andCl-~DrugInteractionTermsDrug’seffectonsynaptictransmissionDirectatpostsynapticreceptorIndirectatanyotherstepAgonist(AG)mimicsorNTeffectsAntagonist(ANT)blocksor¯NTeffects~
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