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ever-diminishing

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everdiminishingSUMMARYOFMEDICALPUBLICATIONSONIMMUNOCALHMSMEDICALHYPOTHESES()():,HARCOURTPUBLISHERSLTDARTICLENOMEHYCOMPETITIONFORGLUTATHIONEPRECURSORSBETWEENTHEIMMUNESYSTEMANDTHESKELETALMUSCLE:PATHOGENESISOFCHRONICFATIGUESYNDROMEGBounous,JMolsonFormerProfessor,DepartmentofSurgery,McGillUniversity,andcareerInvestigationoftheMedicalResearchCouncilofCanadaQuebecCyclingChampionRoadandTimeTrialSUMMARYThechronicfatiguesyndrome(CFS)isBecauseGSHisalsoessentialtoaerobicmusculartypicallyassociatedorfollowsarecognizedorcontraction,anundesirablecompetitionforGSHpresumedinfectionAbnormalitiesofbothprecursorsbetweentheimmuneandmuscularhumoralandcellularimmunityhavebeensystemsmaydevelopItisconceivablethatthedemonstratedinasubstantialproportionofpatientspriorityoftheimmunesystemforthesurvivalofwithCFSThemostconsistentfindingsareofthehosthasdrawntothisvitalareatheeverimpairedlymphocyteresponsestomitogenAsandiminishingGSHprecursors,thusdeprivingtheantioxidant,glutathione(GSH)isessentialforskeletalmuscleedbloodcells(SRBC)AninvestigatedbymeasuringtheresponsetotheTevengreaterenhancingeffectofdietaryLwascellindependentantigen,TNPFicollTonotedinnormal(DBAJxCBAN)FmiceafterinvestigatethepossibleinfluenceofdietaryproteinimmunizationwithSRBC,butincontrast,thetypeonthesupplyofBlymphocytes,bonemarrownormallargescaleproductionofBlymphocytesinlymphocyteproductionhasbeenexaminedbyamousebonemarrowwasindependentofthetypeofradioautographicassayofsmalllymphocytedietaryproteinDietaryproteintypedidnotaffectrenewalandanimmunofluorescentstathmokineticbloodlevelofmineralsandtracemetalsThefreeassayofpreBcellsandtheirproliferationTheplasmaaminoacidprofileessentiallyconformedtohumoralresponseofallmicefedtheLdietwastheaminoacidcompositionoftheingestedprotein,foundtobehigherthanthatofmicefedtheCdietsuggestingthatthechangesinplasmaaminoacidC:CONVERTTEMPDOCprofilemightbeacrucialfactorindietdependentfunctionalresponsivenessoftheBlymphocytesenhancementordepressionoftheBcellresponsethemselvesorintheprocessesleadingtotheirThefindingsindicatethattheobservedeffectsofactivationanddifferentiationintheperipheralaltereddietaryproteintypeonhumoralimmunelymphoidtissuesresponsivenessarenotexertedcentrallyontherateofprimaryBlymphocyteproductionintheboneINDEXINGKEYWORDS:DIET–PROTEIN–IMMUNITYmarrow,butmayreflectchangeseitherinthe–BCELLRESPONSEMICE********************************JNUTR:,DIFFERENTIALEFFECTOFDIETARYPROTEINTYPEONTHEBCELLANDTCELLIMMUNERESPONSESINMICEGustavoBounousandPatriciaALKongshavn*CentreHospitalierUniversitaire,Sherbrooke,Québec,Canada,JHNand*MontrealGeneralHospitalResearchInstituteandDepartmentofPhysiology,McGillUniversity,Montreal,Quebec,Canada,HGYABSTRACT–TheeffectofggdietofdifferamongmicefedthevariousdietsSimilarly,lactalbumin(L),casein(C),soy(S)andwheat(W)thetypeofdietdidnotappeartoinfluencehostproteinontheimmuneresponsivenessofCHHeNresistancetoSalmonellatyphymuriumItismicehasbeeninvestigatedbymeasuringthepostulatedthatthetypeofproteininthediethumoralimmuneresponsetotheTcellinfluencesdirectlytheintrinsiccapacityoftheBindependentantigen,TNPFicollThehumorallymphocytestorespondtoanimmunogenicimmuneresponseofmicefedtheLdietwasfoundstimulustobehigherthanthatofmicefedtheC,SandWdietsOntheotherhand,delayedtypeIndexingKeyWords:diet*protein*immunity*hypersensitivity,andspleniccellmitogenresponsesmicetophytohemagglutininandconcanavalinAdidnotJNUTR:,INFLUENCEOFDIETARYPROTEINTYPEONTHEIMMUNESYSTEMOFMICEGBounous,LLétourneauandPALKongshavn†Centrehospitalieruniversitaire,Sherbrooke,Quebec,CanadaJHNand†MontrealGeneralHospitalResearchInstituteandDepartmentofPhysiology,McGillUniversity,Montreal,Quebec,Canada,HGYABSTRACT–Theeffectofgradedamountsofsubstantiallylowerthanthatofmicefedstockdiet,dietarylactalbumin(L),casein(C),soy(S),wheatwhereasthatofmicefedLdietwashigherThe(W)proteinandPurinarodentchow(stockdiet)onabovedescribedimmuneeffectofalltestedtheimmuneresponsivenessofCHHeNmicehasproteinswasobtainedatggconcentrationbeeninvestigatedbymeasuringthespecificwithnofurtherincrementswithandgghumoralimmuneresponsetosheepredbloodcellsproteininthedietMitogenresponsivenesstoPHA(SRBC),andhorseredbloodcells(HRBC)aswellandConAinLdietfedmicewasonlyslightlyasthenonspecificspleniccellresponsivenesstohigherthanthatofCdietfedmiceLittlephytohemagglutinin(PHA)andconcanavalinAdifferenceinimmuneresponseswasnotedamong(ConA)afterstimulationwithMycobacteriummicefedC,SorWproteindietsTheprincipalbovis,strainBCGThenutritionalefficiencyoffactorresponsiblefortheobservedimmuneeffectthesedietswasnormalandsimilarTheimmunedoesnotappeartobetheavailabilityorresponseofmicefedtheLdiets,wasfoundtobeconcentrationofsingleessentialaminoacidsbutalmostfivetimeshigherthanthatofmicefedtheratherthecompositeeffectofthespecificaminocorrespondingCdietsThehumoralimmuneaciddistributionintheproteinresponseofmicefedC,S,andWdietswasC:CONVERTTEMPDOC*****************************MINERVADIETOLGASTROENTEROL():,CHANGESINBILIARYSECRETORYIMMUNOGLOBULINSAINMICEFEDWHEYPROTEINSCostantinoAM,BalzolaF,BounousGAwheyproteindiethasbeenshowntoenhancerecordedandthegallbladderwasremovedanditssplenicimmuneresponsetosheepredbloodcellswholecontentanalyzedbyELISAtodetermineS(SBRC)inmiceThisstudywasdesignedtoIgAsecretionBodyweightcurvesweresimilarininvestigatetheinfluenceofthetypeofdietaryalldietarygroupshigherbiliarylevelsofSIgAproteinonthebiliarysecretoryIgAAJmicewereappearedinthewheyproteinfedmicethaninthefeddefinedformuladietscontainingeithercasein(plessthan)orpurine(plessthanwheyprotein,orcaseinAnothergroupwas)fedmiceDietaryproteintypemayhaveafedPurinamousechowAfterweeksofdietarydirectinfluenceontheimmuneresponseinthetreatmentthebodyweightofeachmousewasgastrointestinaltract,withoutaffectingbodyweightOXIDATIVESTRESS,CELLACTIVATIONANDVIRALINFECTION,CPASQUIERETAL(EDS),,BIRKHÄUSERVERLAGBASELSWITZERLANDPLACEFORANANTIOXIDANTTHERAPYINHUMANIMMUNODEFICIENCYVIRUS(HIV)INFECTION,SBaruchelGBounous,PGoldMcGillUniversity,DeptofPediatricsMcGillAIDSCentreMontrealQcHHP,CanadaMcGillUniversity,DeptofMedicineMcGillAIDSCentreMontrealQcHGA,CanadaSUMMARYOxidativestress,aknownactivatoragentspromotingGSHsynthesis,arediscussedofHIVreplicationinvitro,hasapotentialroleasaThereviewalsoincludestheearlyresultsofcofactorofHIVdiseaseprogressionArgumentsnutritionalinterventionsbasedonadietenrichedsupportingtheroleofoxidativestressasacofactorwithIMMUNOCAL,,awheyproteinconcentrateinHIVactivationaresummarizedinthisreviewpreparedinaproprietarymannerTheroleofintracellularantioxidantssuchasglutathione(GSH),anddrugsandnutriceutical********************************JNutr:,ReprintedfromTHEJOURNALOFNUTRITIONVol,no,SeptemberTheAmericanInstituteofNutritionINFLUENCEOFDIETARYPROTEINSONTHEIMMUNESYSTEMOFMICEoGBounousandPALKongshavn†oCentreHospitalierUniversitaire,Sherbrooke,Quebec,Canada,JHNand†MontrealGeneralHospitalResearchInstituteandDepartmentofPhysiology,McGillUniversity,Montreal,Quebec,Canada,HGYABSTRACTTheeffectofgradedamountsofresponsetosheepredbloodcells(SRBC)andthedietarylaetalbumin(L)andcasein(C)hydrolyzatesnonspecificspleniccellresponsivenesstoontheimmuneresponsivenessofCHHeNandphytohemagglutinin,concanavalinAandDBAstrainmicehasbeeninvestigatedbyEscherichiacolilipopolysaccharideaftermeasuringboththespecifichumoralimmunestimulationwithMycobacteriurnbovis,strainBCGC:CONVERTTEMPDOCThenutritionalefficiencyofthesedietswassimilarhumoralimmuneresponseTheenhancementofatbothandaminoacidlevelsTheimmuneimmuneresponsivenessobservedinmicefedtheresponsesofmicefedtheLdietswerefoundtobeLdietwasmoderatelyreducedbytheadditionsignificantlygreaterthanthoseofmicefedtheofphenylalaninetothediet,indicatingthatthecorrespondingCdiets,especiallyatthelevellowerlevelofthisaminoacidintheLproteinmayFurthermoreinthemicefedLdiet,increasingthebeofsomesignificanceThesedietaryeffectsonconcentrationofaminoacidinthedietfromtoimmuneresponsivenesswereremarkablysimilaringreatlyenhancedimmuneresponsivenessbybothmousestrainstestedbothparametersmeasuredIntheCfedmice,aINDEXINGKEYWORDS:dietprotein–comparableenhancementofmitogenimmunitymiceresponsivenesswithincreasingaminoacidlevelofdietwasseen,buttherewasnochangeintheTHEJOURNALOFINFECTIOUSDISEASES,:,INFLUENCEOFDIETARYLACTALBUMINHYDROLYSATEONTHEIMMUNESYSTEMOFMICEANDRESISTANCETOSALMONELLOSISGBounous,MMStevenson*,PALKongshavn†Centrehospitalieruniversitaire,Sherbrooke,Quebec,Canada*MontrealGeneralHospitalResearchInstituteand†McGillUniversity,Montreal,Quebec,CanadaABSTRACT–Inthepresentstudyweinvestigatedinthedietabovetheminimumrequirement(theeffectoffourweeksoftreatmentwithadietLAH)andthusproduceaugmentedhumoralcontaininglactalbuminhydrolysate(LAH:Nestlé,immuneresponsivenessandresistancetoVevey,Switzerland)ontheimmuneresponseofsalmonellosisCHHeNmiceOurdataindicatethatitwaspossibletoincreasethelevelofthistypeofproteinLactalbumin=WheyProteinConcentrate*****************************JOURNALOFAPPLIEDPHYSIOLOGY,:,THEEFFECTOFSUPPLEMENTATIONWITHACYSTEINEDONORONMUSCULARPERFORMANCELCLands,MD,PhD*†,VLGrey,PhD†‡,AASmountas,BSc**DivisionofRespiratoryMedicine,†DepartmentofPediatrics,‡DepartmentofBiochemistry,McGillUniversityHealthCentreMontrealChildren’sHospital,Montreal,Quebec,CanadaABSTRACT:OxidativestresscontributestomeasuringPeakPowerandsecWorkCapacitymuscularfatigueGlutathione(GSH)isthemajorLymphocyteGSHwasusedasamarkeroftissueintracellularantioxidant,whosebiosynthesisisGSHTherewerenobaselinedifferences(age,ht,dependentuponcysteineavailabilityWewt,idealwt,PeakPower,secWorkCapacity)hypothesizedthatsupplementationwithawheyFollowupdataonsubjects(Immunocal,basedcysteinedonor(Immunocal(HMS))placebo)wereanalyzedBothPeakPowerdesignedtoaugmentintracellularGSH,would(mean,se:,,p,)andsecWorkenhanceperformanceTwentyhealthyyoungCapacity(,,p,)increasedsignificantlyadults(m)werestudiedpreandmonthspostintheImmunocalgroup,withnochange(,andsupplementationwitheitherImmunocal(gmday),)intheplacebogroupLymphocyteGSHorcaseinplaceboMuscularperformancewasalsoincreasedsignificantlyintheImmunocalgroupassessedbywholelegisokineticcycletesting,C:CONVERTTEMPDOCdefensesresultedinimprovedvolitional(,,p,)withnochangeintheperformanceplacebogroup(,)ThisisthefirststudytodemonstratethatprolongedsupplementationKeywords:oxidativestress,exercisewithaproductdesignedtoaugmentantioxidantACCEPTEDFORPUBLICATIONIN“CHEST”TREATMENTOFOBSTRUCTIVEAIRWAYDISEASEWITHACYSTEINEDONORPROTEINSUPPLEMENT:ACASEREPORTBryceLothian,MD*,VijaylaxmiGrey,PhD*†,RJohnKimoff,MD‡,LarryLands,MD,PhD**DepartmentofPediatrics,†DepartmentofBiochemistry,DivisionofRespiratoryMedicine,McGillUniversityHealthCentreMontrealChildren’sHospital,Montreal,Quebec,Canada‡DivisionofRespiratoryMedicine,McGillUniversityHealthCentreRoyalVictoriaHospita,Montreal,Quebec,CanadaABSTRACT:OxidantantioxidantimbalancecanglutathionelevelsFollowingonemonthofoccurinobstructiveairwaysdisease,asaresultofsupplementationwithawheybasedoralongoinginflammationGlutathioneplaysamajorsupplement,designedtoprovideglutathioneroleinpulmonaryantioxidantprotectionAsanprecursors,wholebloodglutathionelevelsandalternativeorcomplementtoantiinflammatorypulmonaryfunctionsignificantlyanddramaticallytherapy,augmentingantioxidantprotectioncouldincreasedThepotentialforsuchsupplementationdiminishtheeffectsofinflammationWedescribeinpulmonaryinflammatoryconditionsdeservesacaseofapatientwithobstructivelungdisease,furtherstudyresponsivetocorticosteroids,withlowwholeblood**********************************PRTREATMENTOFCHRONICHEPATITISUSINGWHEYPROTEIN(NONHEATED)AWatanabe,KHiguchi,KOkada,YShimizu,YKondo*andHKohri*DepartmentofInternalMedicine,ToyamaMedicalandPharmaceuticalUniversity,Toyama,Japan,and*OtsukaPharmaceuticalFactory,Inc,NutritionResearchInstitute,TokushimaJapanInanopenstudy,theclinicalefficacyofwheyweekintervalsforweekstoevaluatetheefficacyprotein(Immunocal:cysteinecontentfoldthatofImmunocalAsaresult,serumALTactivityofcasein)isolatedfromfreshmilkandpurifieddecreasedinofpatientswithchronichepatitisBwithoutbeingheatedwasevaluatedbasedonliverweeksafterthestartofsupplementwithfunctiontest,immunologicalparameters,plasmaorImmunocalfoodPlasmaGSHconcentrationswerelymphocyteGSHconcentrationsandhepatitisvirusincreasedinofthepatientsSerummarkersinpatientswithchronichepatitisBorCconcentrationsoflipidperoxidessignificantlyImmunocal(gasprotein)food(mousse)wasdecreasedweeksafterImmunocalfoodSerumgiventwiceaday,inthemorningandevening,forILlevelsbegantoincreaseweeksandremainedweeks(testperiod)Casein(gasprotein)highevenaftersupplementwithImmunocalfoodfood(mousse)wasgivenforweekspriortothehadendedFurthermore,NKactivitywasstartofsupplementwithImmunocalfoodsignificantlyincreasedHowever,anitem(inductionperiod)andforweeksaftertheendcorrelatingwithreducedserumALTactivitycould(followupperiod)TheeffectsofImmunocalfoodnotbeclarifiedInpatientswithchroniconvariousclinicalparameterswereexaminedathepatitisC,thereworenosignificantImmunocalC:CONVERTTEMPDOCrelatedchangesinliverfunctiontestorB,andafurtherclinicalstudythatlongtermimmunologicalparametersThesefindingssuggestcombinationtherapywithImmunocalandotherthatlongtermsupplementwithImmunocalaloneagentsincludinginterferonmaybeeffectiveformaybeeffectiveforpatientswithchronichepatitisthosewithchronichepatitisCshouldbeperformedAnticancerResearch:,WHEYPROTEINCONCENTRATE(WPC)ANDGLUTATHIONEMODULATIONINCANCERTREATMENTGustavoBounous,MD,FRCS(C)ABSTRACTTheglutathione(GSH)antioxidantproteinsalsoexhibitanticarcinogenesisandsystemisforemostamongthecellularprotectiveanticanceractivityTheydothisviatheireffectonmechanismsDepletionofthissmallmoleculeisaincreasingGSHconcentrationinrelevanttissues,commonconsequenceofincreasedformationofandmayhaveantitumoreffectonlowvolumeofreactiveoxygenspeciesduringincreasedcellulartumorviastimulationofimmunitythroughtheactivitiesThisphenomenoncanoccurintheGSHpathwayItisconsideredthatoxygenradicallymphocytesduringthedevelopmentofthegenerationisfrequentlyacriticalstepinimmuneresponseandinthemuscularcellsduringcarcinogenesis,hencetheeffectofGSHonfreestrenuousexerciseItisnotsurprisingthatsomuchradicalsaswellascarcinogendetoxification,couldresearchhasbeendone,andisstillbeingdoneonbeimportantininhibitingcarcinogenesisinducedthissmalltripeptidemoleculeWheyproteinbyanumberofdifferentmechanismsCasereportsconcentratehasbeenshowntorepresentanarepresentedwhichstronglysuggestanantitumoreffectiveandsafecysteinedonorforGSHeffectofawheyproteindietarysupplementinsomereplenishmentduringGSHdepletioninimmuneurogenitalcancersThisnontoxicdietarydeficiencystatesCysteineisthecruciallimitingintervention,whichisnotbasedontheprinciplesofaminoacidforintracellularGSHsynthesisAnimalcurrentcancerchemotherapy,willhopefullyattractexperimentsshowedthattheconcentratesofwheytheattentionoflaboratoryandclinicaloncologists*****************************ACCEPTEDFORPUBLICATIONINNUTRITIONANDCANCER,VOL,ISSUE#ENHANCINGEFFECTOFPATENTEDWHEYPROTEINISOLATE(IMMUNOCAL,)ONTHECYTOTOXICITYOFANTICANCERDRUGWayneYTsai,WenHueiChang,ChingHseinChen,andFungJouLuDepartmentofBiochemistry,CollegeofMedicineNationalTaiwanUniversity,Taipei,Taiwan,ROCABSTRACT–TodeterminetheenhancingeffecttherewasnosignificantdifferenceonsurvivalrateofawheyproteinisolateonthecytotoxicityofaIntheinvestigationofapoptosiscomparedtothepotentialanticancerdrugbaicalein,humancellsinbaicaleinmedium,cellsincombinedhepatomacelllineHepGwasassignedtogrowinmediumshowedahigherphosphatidylserinedifferentmediaforfourdays,followedbytheexposure,lowerrnitochondrialtransmembraneinvestigationofcellgrowthandapoptosispotentialandnearlytimesmorecellswereExcludingthecontrolgroupwithnormalmedium,detectedundergoingapoptosisWealsootherthreetreatmentmediaincludedwheyproteindemonstratedthatImmunocal,wasabletoreduceisolate(marketedasImmunocal,)medium,glutathioneinHepGbytoandregulatedbaicaleinmedium,andcombinedmediumtheelevationofglutathione,whichwasinresponsecontainingbothIrnmunocal,andbaicaleinMTTtobaicaleinInconclusion,Immunocal,seemedtoassayindicatedthatcellsgrewincombinedenhancethecytotoxicityofbaicaleinbyinducingmediumhadasignificantlylowersurvivalratemoreapoptosis,thisincreaseinapoptoticcellsmaycomparedtothecellsgrewinbaicaleinmediuminbeinassociationwiththedepletionofGSHinHepGThisisthefirststudytodemonstrate,incontrast,forthecellsgrewinImmunocal,group,C:CONVERTTEMPDOCadjuvantincancertreatmentsvitro,thatImmunocal,mayfunctionasanOXIDATIVESTRESSINCANCER,AIDS,ANDNEURODEGENERATIVEDISEASES–LUCMONTAGNIERETAL,(ED)MARCELDEKKERINC,NEWYORK:,NUTRICEUTICALMODULATIONOFGLUTATHIONEWITHAHUMANIZEDNATIVEMILKSERUMPROTEINISOLATE,IMMUNOCAL,:APPLICATIONINAIDSANDCANCERSBaruchel*,GViau*,ROlivier**,GBounous***,MAWainberg*****McGillUniversity–MontrealChildren’sHospitalResearchInstitute,Montreal,Quebec,Canada,**PasteurInstituteParis,France,***MontrealGeneralHospital,Montreal,Quebec,Canada,****JewishGeneralHospital,LadyDavisInstitute,Montreal,Quebec,CanadaABSTRACT–ThebiologicalactivityoftheoxidativestressandpathologyofGSHmetabolismarelargelyimplicatedInapilotstudy,thistypeofproteinsisolatedfromcow’smilkinImmunocal,wheyproteinconcentratewasfoundtobewelldependsonthepreservationofthoselabileproteinstoleratedinchildrenwithAIDSandwastingwhichsharewiththepredominanthumanmilksyndromeandwasfoundassociatedwithanproteinsthesameextremelyrareglutathioneimprovementofthenutritionalstatusofthepatient(GSH)promotingcomponentsCellularGSHMoreover,theGSHpromotingactivityonthedepletionhasbeenimplicatedinthepathogenesisperipheralbloodlymphocyteofthisproteinofanumberofdegenerativeconditionsanddiseaseconcentratewasvalidatedinpatientswithinitialstatesincludingParkinson’s,Alzheimer’s,lowGSHlevelsExtensivepharmacoarteriosclerosis,cataracts,cysticfibrosis,epidemiologicalstudyofGSHmetabolismandmalnutrition,aging,AIDS,andcancerstandardizedmethodsofmeasurementofintracellularGSHapplicableinclinicaltrialsareThisnewlydiscoverednutriceuticalmodulationofneededinordertobetterdefinetheclinicalGSHbytheuseofhumanizednativemilkserumapplicationofthisnewtypeoftherapyproteinisolateofbovineorigininAIDSandcancermaywellfindotherapplicationsindiseasewhere*****************************ANTICANCERRESEARCH:()THEANTIOXIDANTSYSTEMGBounousandJHMolsonResearchandDevelopmentDepartmentImmunotecResearchLtd,VaudreuilDorion,Quebec,CanadaABSTRACT–Theglutathione(GSH)forGSHreplenishmentduringtheimmuneantioxidantsystemistheprincipalprotectiveresponseAnimalexperimentsshowedthatthemechanismofthecellandisacrucialfactorinconcentratesofwheyproteinalsoexhibitthedevelopmentoftheimmuneresponsebytheanticanceractivityTheydothisviatheGSHimmunecellsExperimentaldatademonstratepathway,theinductionofpproteininthatacysteinerichwheyproteinconcentratetransformedcellsandinhibitionofrepresentsaneffectivecysteinedeliverysystemneoangiogenesisCANJCARDIOLVOL,NO,SEPTEMBERC:CONVERTTEMPDOCMILKWHEYPROTEINDECREASESOXYGENFREERADICALPRODUCTIONINAMURINEMODELOFCHRONICIRONOVERLOADCARDIOMYOPATHYWJBartfay,MTDavis,JMMedves,SLugowskiABSTRACT–Chronicironoverloadisamajor),HNE()andhexanal(causeoforganfailureworldwide,butits)wereobservedinthehearttissueofthepathogenesisremainstobeelucidatedgroupreceivingironwithwhey,incomparisonToexamineinanexperimentalmurinewiththeirononlytreatmentgroup(MDAmodelofironoverloadcardiomyopathythe,HNE,hexanal,relationbetweenmilkwheyproteinand,first,theP<)SignificantlyincreasedGPx(productionofreactiveoxygenfreeradicalIUL)andGSH(IUL)activityspeciesand,second,antioxidantreservestatuswereobservedinmicereceivingironwithwhey,BDFmicewererandomlyassignedtoincomparisonwithmicereceivingirononlyfourtreatmentgroups(n=pertreatmentgroup):(GPxIUL,GSHIULplacebocontrolirononlywheyonlyandironP<)withwheyReactiveoxygenfreeradicalspeciesMicereceivingirontreatmentswithwheyintheheartwerequantifiedbythecytotoxicsupplementationhadsignificantlyloweraldehydesmalondialdehyde(MDA),hydroxyconcentrationsofcytotoxicaldehydesandnonenal(HNE)andhexanal,whileantioxidantsignificantlyhighercardiaclevelsofGPxandreservestatuswasquantifiedbyglutathioneGSHactivitythandidirononlytreatedmice(GSH)andglutathioneperoxidase(GPx)activityAdditionalbasicresearchiswarrantedtointhehearttissueexaminetheexactmechanismsbywhichmilkSignificantlydecreasedconcentrationswheyproteinprotectstheheart(pmolmgwetweighttissue)ofMDA(*****************************C:CONVERTTEMPDO
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