美国伊利诺芝加哥大学微生物学与免疫学终身教授

美国伊利诺芝加哥大学微生物学与免疫学终身教授 CHEN, Zheng W., M.D., Ph.D. 美国伊利诺芝加哥大学微生物学与免疫学终身教授、生物医学研究中心主任陈维政博士的 简历。他愿意与我院合作培养研究生。 CURRICULUM VITAE Name: Zheng Wei Chen Office Address: Harvard Medical School, Beth Israel Deaconess Medical Center 330 Brookline Avenue, RE113 Boston, MA 02215 University of Illinois Chicago 835 S. Wolcott Ave, MC790 Chicago, IL 60612 E-Mail: zchen@uic.edu; Phone: 617 667-2061; FAX: 617-667-8210 Education: 1983 M.D., Canton Medical College, China 1988 Ph.D., Peking Union Medical College and Chinese Academy of Medical Science/Immunology 1994 M.D., USMLE, USA Internship and Residencies: 1983-1984 Resident in Medicine, Canton Medical School Hospital 1984-1987 Resident in Medicine, Peking Union Medical School Hospital 1987-1988 Chief Resident in Medicine, Peking Union Medical School Hospital Clinical and Research Fellowships: 1988-1989 Fellow in Rheumatology and Immunology, Peking Union Medical School Hospital 1989-1992 Research Fellow in Immunology, Harvard University, New England Primate Center Licensure and Certification: 1989 Rheumatologist (China) 1994 United States Medical Licensing (USMLE # 05188958) Awards and Honors 1993 Clinical Investigator Award, NIH, USA 1994 FIRST Award, NIH, USA NIH Study Sections (Ac hoc) 2001-03 NIH NHLBI Genetics of TB Study Section NIH NHLBI Study Section for Minority Faculty NIH NIAAA Study Section, HIV/AIDS. NIH NIAID BM-1 Study Section, Tuberculosis Journal Reviewers 1995- present Journal of Immunology, Journal of Virology; Journal of Infectious Diseases; Hum Retrovirus Academic Appointments: 1989-1992 Postdoctoral Research Fellow, Harvard University 1992-1995 Instructor in Medicine, Harvard Medical School 1995- 1999 Assistant Professor of Medicine, Harvard Medical School 1999-2000 Sitlington Endowed Chair and Associate Professor of Immunology, Oklahoma State University. 1 CHEN, Zheng W., M.D., Ph.D. 2001-04 Associate Professor of Medicine, Harvard Medical School 2001-04 Head, Tuberculosis Research Unit, Beth Israel Deaconess Medical Center, Boston MA 2004 - Director, Center for Biomedical Research, University of Illinois Chicago (UIC) 2004 - Tenure Professor of Microbiology and Immunology, UIC, Chicago, IL Hospital Appointments: 1994- Staff Physician, Beth Israel Deaconess Medical Center, Department of Medicine Research Funding Information Past Funding: 1993-1996 NIH K08-AI01189 PI Immune response to SIV 1994-1999 NIH R29-AI36628 PI SIV superantigen and TCR repertoires 1999-2000 Pittsfield Anti-TB Association PI 1999-2003 NIH P01-DK57958 (Thomas, J) PI Restoration of T cell repertoire after depletion 07/1998 – 06/2004 NIH R01-RR13601 PI SIV/BCG coinfection 11/1999 – 10/2004 NIH R01-HL64560 PI Model of AIDS-Related Tuberculosis Present Funding: 02/2004- 01/2009 NIH R01 HL64560 PI Years 6 - 10 V,2V,2 T cells and AIDS/TB model (A total of $4.01 million for 5 years) 08/2003 - 01/2008 NIH P01 AI052816 PI HIV, TB and malaria vaccine development (A total of $2.8 million) 12/2004 – 11/2009 NIH R01-RR13601 PI Years 6 - 10 Role of CD8 T cells in immunity to TB (A total of $3.3 million for 5 years) 10/2004- 09/2006 NIH R21 PI Universal vaccine for biodefense ($680,000) Pending: 02/2004- 01/2008 NIH R01 AI058883 PI SIV therapeutics Bibliography: 1. Chen ZW, Zhang NZ, Jiang M. Detection of antineuronal antibodies and their values in diagnosis of neuropsychiatric SLE. 1990. Chinese J. Internal Med. 1990 Mar;29(3):161-4, 190. 2. Watkins DI, Chen ZW, Hughes AL, Hodi FS, Letvin NL. Genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar MHC class I gene products. J Immunol 1990;144:3726-3735. 3. Watkins DI, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL. Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature 2 CHEN, Zheng W., M.D., Ph.D. 1990;346:60-63. 4. Watkins DI, Chen ZW, Hughes AL, Lagos A, Lewis AM, Shadduck JA, Letvin NL. Syrian hamsters express diverse MHC class I gene products. J Immunol 1990;145:3483-3490. 5. Watanabe M, Chen ZW, Tsubota H., Lord CI, Levine CG, Liu T, Letvin NL. Soluble human CD4 elicits an antibody response in rhesus monkeys that inhibits simian immunodeficiency virus replication. Proc Natl Acad Sci 1991;88-120-124. 6. Watkins DI, Garber TL, Chen ZW, Toukatly G, Hughes AL, Letvin NL. Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species. Immunogenetics 1991;33:79-89. 7. Shen L, Chen ZW, Miller MD, Stallard V, Mazzara GP, Panicali DL, Letvin NL. Induction of simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes following vaccination with a recombinant virus vaccine. Science 1991;252:440-443. 8. Chen ZW, McAdam SN, Hughes AL, Dogan AL, Letvin NL, Watkins DI. Molecular cloning of orangutan and gibbon MHC class I cDNAs: The HLA-A and - B loci diverged over 30 million years ago. J Immunol 1992;148:2547-2554. 9. Hasunuma T, Tsubota H, Watanabe M, Chen ZW, Lord CI, Burkly LC, Daley JF, Letvin NL. Regions of the CD4 molecule not involved in virus binding or syncytia formation are required for HIV-1 infection of lymphocytes. J Immunol 1992;148:1841-1846. 10. Watkins DI, Chen ZW, Garber TL, Hughes AL, Letvin NL. Segmental exchange between MHC class I genes in a higher primate: Recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene. Immunogenetics 1992;34:185-191. 11. Chen ZW, Hughes AL, Letvin NL, Watkins DI. Evolution of great ape MHC class I genes. Molecular Evolution of the Major Histocompatibility Complex. In: NATO ASI Series: Klein J and Klein D, eds., Springer-Verlag, Berlin, 1992; Vol H59: p. 171-175. 12. Chen ZW, Yamamoto H, Watkins DI, Levinson G, Letvin NL.A predominant use of a T cell receptor Vß gene family in SIV gag-specific cytotoxic T lymphocytes in a rhesus monkey. J Virol 1992;66:3913-7. 13. Chen ZW, Shen L, Miller MD, Ghim SH, Hughes AL, Letvin NL. Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag. J Immunol 1992;149:4060-4066. 14. Chen ZW, Yamamoto H, Watkins DI, Levinson G, Letvin NL. TCR Vß genes in SIVmac gag-specific cytotoxic T lymphocytes. Vaccines 92. Cold Spring Harbor Laboratory, New York. 1993; p. 237-241. 15. Letvin NL, Chen ZW, Yamamoto H, Watanabe M. Active immune therapy for the treatment of HIV infections. AIDS Res Hum Retroviruses 1992;8:1499. 16. Chen ZW, Kou Z-C, Shen L, Reimann KA, Letvin NL. Conserved T cell receptor repertoire in SIVmac infected rhesus monkeys. J Immunol 1993;151:2177-2187. 17. Chen ZW, Hughes AL, Ghim SH, Letvin NL, Watkins DI. Two more chimpanzee MHC Class I A locus alleles related to the HLA-A1/A3-A11. Immunogenetics 1993;38:238-240. 18. Chen ZW, Kou Z-C, Shen L, Regan JD, Lord CI, Halloran M, Lee-Parritz D, Fultz PN, Letvin NL. An acutely lethal simian immunodeficiency virus stimulates expansion of Vß7- and Vß14-expressing lymphocytes. Proc Natl Acad Sci 1994;91:7501-7505. 19. Shen L, Chen ZW, Letvin NL. The repertoire of cytotoxic T lymphocytes in the recognition of mutant simian immunodeficiency virus variants. J Immunol 1994;153: 5849-5854. 20. Chen ZW, Kou Z, Zhou D, Halloran M, Shen L, Li J, Sodroski J, Lee-Parritz D, Letvin NL. T cell receptor repertoire of CD8+ lymphocytes in an acute infection of rhesus monkeys with SIVmac and SHIV. J Exp Med 1995;182:21-32. 21. Chen ZW, Shen L, Regan JD, Kou Z, Letvin NL. T cell receptor gene usage by SIVmac Gag-specific cytotoxic T lymphocytes in rhesus monkeys. J Immunol 1996;156:1469-1475. 22. Chen ZW, Zhou DJ, Chalifoux L, Lee-Parritz D, Letvin NL. Disseminated granulomatous disease in an 3 CHEN, Zheng W., M.D., Ph.D. SIVmac/BCG-coinfected rhesus monkey. AIDS 1997;11:266-267. 23. Letvin NL, Yasutomi Y, Shen L, Reimann KA, Chen ZW, Schmitz JE, Kuroda MJ. The CD8+ T lymphocyte response during primary SIVmac infection. Adv Exp Med Biol 1998;452:177-9 24. Kou Z, Halloran M, Shen L, Lee- Parritz D, Simon M, and Chen ZW. In vivo effects of a bacterial superantigen on macaque T cell receptor repertoires. J Immunol 1998;160:5170-80. 25. Zhou D, Chalifoux L, Halloran M, Lee- Parritz D, Simon M, Sehgal P, Chen ZW. Anergy and dysfunction of CD4+ T cells and V,2V,2+ T cells associated with Mycobacterium bovis BCG-induced tuberculosis in SIV-infected macaques.Int J Tuberculosis and Lung Disease 1998;Vol 2(11);s2, 213. 26. Zhou D, Kou Z, Ibegbu C, Shen Y, Lee-Parritz D, Shen L, Sehgal PK, McClure HM, Morrison P, Bogle C, Sehgal N, Nahmias AJ, Chen ZW. The disruption of macaque CD4+ T cell repertoires during the primary simian immunodeficiency virus infection. J Med Prim 1999;28:174-180. 27. Zhou D, Shen Y, Chalifoux L, Halloran M, Lee- Parritz D, Simon M, Sehgal P, and Chen ZW. Mycobacterium bovis BCG enhances pathogenicity of simian immunodeficiency virus infection and accelerates progression to AIDS in macaques: A Role of Persistent T cell Activation in AIDS Pathogenesis. J Immunol 1999;162:2204. 28. Chen ZW, Shen Y, Davis IC, Shen L, Letvin NL, Fultz PN. Simian Immunodeficiency Virus evades a dominant epitope-specific cytotoxic T lymphocyte response through a mutation resulting in the accelerated dissociation of viral peptide and MHC class I. J Immunol. 2000;164:6474-9. 29. Chen ZW, Shen Y, Kou Z, Ibegbu C, Zhou D, Shen L, Morrison P, Bogle C, McClure HM, Nahmias AJ, Sehgal PK, Letvin NL. Prolonged dominance of clonally restricted CD4+ T cells in macaques infected with simian immunodeficiency viruses. J Virol. 2000;74:7442-50. 30. Chen ZW, Shen Y, Davis IC, Shen L, Letvin NL, Fultz PN. Down-regulation of macaque ,, + T cells in lymphoid compartments after rectal infection with SIVsmmPBj14. J Med Prim.2000;29:143-7. 31. Chen ZW, Li Y, Zeng X, Kuroda MJ, Schmitz JE, Shen Y, Lai X, Shen L, Letvin NL. The T cell receptor +repertoire of an immunodominant CD8 T lymphocyte population. J. Immunol. 2001;166:4525-33. 32. Chen ZW, Shen Y, Zhou D, Simon M, Kou Z, Lee-Parritz D, Shen L, Sehgal P, Letvin NL. In vivo T lymphocyte activation and transient reduction of viral replication in macaques infected with simian immunodeficiency virus. J Virol. 2001; 75:4713-20. 33. Shen Y, Shen L, Sehgal P, Zhou D, Simon M, Miller M, Enimi EA, Henckler B, Chalifoux L, Sehgal N, Gastron M, Letvin NL, Chen ZW. Antiretrovirals restore mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCG. J. Virol; 2001;75(18):8690-6. 34. Hubbard WJ, Moore JK, Contreras JL, Smyth CA, Chen ZW, Lobashevsky AL, Nagata K, Neville DM Jr, Thomas JM. Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques. Hum Immunol 2001;62:479-87. 35. Ibegbu C, Brodie-Hill A, Kourtis AP, Carter A, McClure H, Chen ZW, Nahmias AJ. Use of human CD3 monoclonal antibody for accurate CD4+ and CD8+ lymphocyte determinations in macaques: phenotypic characterization of the CD3- CD8+ cell subset. J Med Prim 2001 Dec;30(6):291-8 36. Shen Y, Zhou D, Chalifoux L, Shen L, Simon M, Zeng X, Lai X, Li Y, Sehgal P, Letvin NL, Chen ZW. Induction of an AIDS virus-related tuberculosis-like disease in macaques: a model of simian immunodeficiency virus- mycobacterium coinfection. Infection and Immunity; 2002 70:869-77. 37. Shen Y, Zhou D, Qiu L, Lai X, Simon M, Shen L, Kou Z, Wang Q, Jiang L, Estep J, Hunt R, Clagett M, Sehgal PK, Li Y, Zeng X, Morita CT, Brenner MB, Letvin NL, Chen ZW. Adaptive Immune Response +of V,2V,2 T Cells During Mycobacterial Infections. Science. 2002, 295;2255-8. 38. Zhou D, Lai X, Shen Y, Sehgal P, Shen L, Simon M, Qiu L, Huang D, Du G, Wang Q, Letvin N, Chen ZW. + Inhibition of adaptive immune response of V,2V,2 T cells during active mycobacterial co-infection of SIV-infected monkeys. J Virol. 2003 Mar;77(5):2998-3006. 39. Wang H, Lee H, Bukowski J, Li H, Mariuzza R, Chen ZW, Nam KH, Morita CT Conservation of nonpeptide antigen recognition by rhesus monkey V,2V,2 T cells. J Immunol 2003;170(7):3696-706. 40. Chen ZW. Comparative biology of ,, T cells. Science Progress. 2002, 85 (4), 347–358 4 CHEN, Zheng W., M.D., Ph.D. 41. Chen, ZW, Letvin NL. Adaptive immune response of ,, T cells: a new paradigm. Trends in Immunology (Immunology Today) 2003, 24(4):213-9. 42. Chen ZW, Letvin NL. V,2V,2 T cells and anti-microbial immune responses. Microbes and Infection, 2003, 5:491-8. 43. Lai X, Shen Y, Zhou D, Simon M, Chalifoux L, Shen L, Sehgal P, Letvin NL, Chen ZW. Immune Biology of Macaque Lymphocyte Populations in a Mycobacterial Infection. Clin. Exp Immunol. 2003, 133:182-92. 44. Shen L, Shen Y, Sehgal P, Qiu L, Huang D, Du G, Miller MD, Letvin N, and Chen ZW. The development of adaptive immune responses of V,2V,2 T cells during active mycobactreial coinfection of SIVmac- infected monkeys requires control of viral infection and immune competence of CD4+ T cells. J. Infectious Dis. 2004, in press. 45. Chen Y. Cai J, Xu J, Chen ZW. Atomic force bio-analytics of polymerization and aggregation of phycoerythrin-conjugated immunoglobulin G molecules. Molecular Immunology, 2004, accepted for publication. 46. Chen ZW Immunology of AIDS virus-mycobacterial coinfection. Current HIV Research, 2004, in press. 47. Chen ZW. Gamma delta T cells in mycobacterial infections. Clin. Immunol. 2004, accepted. 48. Mo L, Zhang WH, Wang J, Weng XH, Chen s, Shao LY, Pang MY, and Chen ZW. Three-dimension model of M. tuberculosis catalase-peroxidase (katG) and mechanisms of katG enzyme activities. Microbial and Drug Resistance. 2004, in press. 49. Zhang WH, Shen L, Shen Y, and Chen ZW. ,, T cells and human diseases. Cytoniques. 2004, in press. Shen Y, Shen L, Sehgal P, Qiu L, Huang D, Du G, Letvin N, and Chen ZW. Latency and reactivation of AIDS- related mycobacterial coinfection. J. Virol. 2004, in press. 豆丁致力于构建全球领先的文档发布与销售平台，面向世界 范围提供便捷、安全、专业、有效的文档营销服务。包括中国、日本、韩国、北美、欧洲等在内的豆丁全球分站，将面向 全球各地的文档拥有者和代理商提供服务，帮助他们把文档发行到世界的每一个角落。豆丁正在全球各地建立便捷、安 全、高效的支付与兑换渠道，为每一位用户提供优质的文档交易和账务服务。 50. 5