硝酸酯、毛细血管新生、血管内皮生长因子 中文（Nitrate, capillary neovascularization, vascular endothelial growth factor, Chinese）

硝酸酯、毛细血管新生、血管内皮生长因子 中文（Nitrate, capillary neovascularization, vascular endothelial growth factor, Chinese） 硝酸酯、毛细血管新生、血管内皮生长因子 中文(Nitrate, capillary neovascularization, vascular endothelial growth factor, Chinese) CBM total field: nitrate and (VEGF, or, vascular endothelial growth factor) 3 One Serial number: 2010355629 [] [CA]: # [classification number]: *R542.2; R-332; R284.1;; R322.11; R331.37; R542.22 [title] the effect of resveratrol on cardiac neovascularization and coronary collateral circulation after AMI [author]: Zhou Zhaofeng; Xu met; Zhang Chaoqun; Zhang Zhuoqi; Wang Zhirong [author] Affiliated Hospital of Xuzhou Medical College, Jiangsu 221002, Xuzhou, China [provinces and cities]: Jiangsu Abstract: Objective: to further investigate the protective effect of resveratrol on the cardiovascular system after acute myocardial infarction (AMI). Methods: 32 New Zealand rabbits were randomly divided into four groups of 8, B, C, D group by ligating the left anterior descending coronary artery to establish the AMI model, A group (sham operation group) except without artery ligation is the same. More than 24 h after the operation of A and B group were administered saline, group C was treated with long-acting isosorbide dinitrate + saline, group D was treated with resveratrol + saline. Rats were continuously administered 15 d after death, the heart samples were obtained at -80 DEG C, save or 4% formalin fixed paraffin slice, detection of myocardial infarcted area and infarct zone of microvascular density (MVD) and vascular endothelial growth factor (VEGF) and angiopoietin -1 (Ang-1) expression. Results: the infarct size in group C and group D was significantly smaller than that in group B, and the expression of MVD and VEGF and Ang-1 in the marginal infarct area was significantly higher than that in group B (P, <0.05), and the expression of Ang-1 in group D was significantly higher than that in group C (P<0.05). Conclusion: resveratrol can promote cardiac neovascularization and coronary collateral circulation after AMI, and can be used as an alternative to patients who are intolerant of nitrates and are not suitable for interventional coronary artery bypass grafting surgery [reference number]: 0 [Abstract] AA [foundation] project supported by Jiangsu Provincial Education Department (08KJB320015) [source: Shandong Medicine 2010; 50 (23) 42-43 [ISSN]: 1002-266X [domestic code]: 37-1156/R [internal code]: S03 [publication]: Shandong, Ji'nan Keywords: Resveratrol; vascular endothelial growth factor; angiopoietin -1; neovascularization; physiological; collateral circulation [subject words] * * two: styrene; coronary artery bypass; sodium chloride; gastric lavage; * myocardial infarction; heart / anatomy and histology; students; vascular endothelial growth factor A [characters]: animals; humans; rabbits [update date]: 20101015 Two Serial number: 2007338291 [] [CA]: # [classification number]: R289.5; R341; R349.21;; *R541.4; R543.3; R977.6 [title]: the effect of Tianxiangdan factors and related factors on the growth of vascular endothelial in patients with coronary heart disease [English title]: Effect, of, Tianxiangdan, on, Serum, Vascular, Endothelial, Growth, Factor, and,, Correlative, Factors, in, Disease, Coronary, Heart,... [author]: holly; Hu Jinxia; Zhao Mingfen; Zheng Jing [author] [Affiliated Hospital of traditional Chinese medicine of Xinjiang Medical University, 830000 [provinces and cities]: Xinjiang [Abstract]: Objective: To investigate the effect of Tianxiangdan on stable angina pectoris patients serum vascular endothelial growth factor (VEGF) and nitric oxide (NO) and nitric oxide synthase (NOS) content. Methods: 99 cases of patients with stable angina pectoris of coronary heart disease were randomly divided into 3 groups, the treatment group of 36 cases, with Tianxiangdan 18g/d on the basis of Western medicine treatment; the control group 34 cases, on the basis of Western medicine treatment Tongxinluo capsule 12 capsules daily, the control group of 29 cases, the basic treatment of Western medicine plus nitrates 28d, for 1 courses, observe the changes of patients before and after treatment of angina attack frequency and duration, electrocardiogram, and serum VEGF, NO and NOS content changes. Results: compared with the control group II, the number of angina attacks in the treatment group and the control group was statistically significant (P<0.05). The total effective rate of ECG in treatment group, control group I and control group was 83.33%, 70.59% and 68.97% respectively, the difference was not statistically significant (P>0.05). The serum levels of NO and VEGF in the treatment group were significantly lower than those in the control group (P<0.01). Conclusion: Tianxiangdan can improve the serum VEGF, NO and NO content, promote the establishment of the coronary collateral circulation, improve myocardial hypoxia, so as to achieve the purpose of treating coronary heart disease. [reference number]: 0 [Abstract] AA [Journal of integrated traditional Chinese and Western medicine: Journal of cardiovascular and cerebrovascular diseases 2007; 5 (8) 662-664 [ISSN]: 1672-1349 [domestic code]: 14-1312/R [internal code]: ZX10 [publication]: Shanxi, Taiyuan [keyword]: Tianxiangdan; stable angina pectoris; vascular endothelial growth factor; angiogenesis [Keywords] * Danshen injection; * coronary artery disease; Statistics (subject); angina pectoris; vascular endothelial growth factor A; * vascular endothelial growth factor; * nitric oxide; nitric oxide synthase [characteristic words: man [update date]: 20071130 Three Serial number: 2003543511 [] [CA]: # [classification number]: R331.37; R341; R349.21; R542.220.5; R977.6 [title] the significance of VEGF in acute myocardial infarction [English title]: Relationship, between, the, levels, of, serum, vascular, endothelial, growth,, factor, and, infarction, acute, myocardial [literature type]: English abstract [author]: Lu Fang; Duan Junli; Wang Yi [unit] Department of Geriatrics, Xinhua Hospital, Shanghai Second Medical University, 200092 [provinces and cities]: Shanghai Abstract: Objective: To investigate the changes and significance of serum vascular endothelial growth factor (VEGF) in patients with acute myocardial infarction (AMI). Methods: the changes of serum VEGF in 16 AMI patients before and after coronary angioplasty, heparin, nitrates and aspirin were observed. The content of serum VEGF was determined at first, third, 14d and 28d respectively. Results: there was no significant difference in serum concentration of VEGF between 1D and control group (85 + 11), vs (72 + 2) pg/mL (P>0.05). The concentrations of 3D and VEGF after the onset were significantly higher than that of 1D (150 + 46), vs (85 + 11) pg/mL (P<0.001). The peak reached 7d (171 + 31) vs (85 + 11) pg/mL (P<0.0001) after the onset of disease. After that began to decline, but the 28d remained significantly higher than the 1D (142 + 132) vs (85 + 11) pg/mL (P<0.001). Conclusion: the level of VEGF increases obviously after AMI treatment, which may be related to the angiogenesis of ischemic myocardium and the establishment of coronary collateral circulation. [reference number]: 9 [Abstract] AA [source: Journal of Shanghai Second Medical University, 2004.06.25; 24 (6) 466-468 [ISSN]: 0258-5898 [domestic code]: 31-1259/R [internal code]: S15 [publication]: Shanghai Keywords: collateral circulation; acute myocardial infarction; vascular endothelial growth factor (VEGF) [keyword]: * * collateral circulation; endothelial growth factor; myocardial infarction / therapy; vascular endothelial growth factor * [characteristic words: man [update date]: 20040930