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首页 Redox Regulation in Cancer A Double-edged Sword…

Redox Regulation in Cancer A Double-edged Sword with Therapeutic Potential.doc

Redox Regulation in Cancer A Do…

上传者: 逛街狂人angela 2018-04-30 评分 0 0 0 0 0 0 暂无简介 简介 举报

简介:本文档为《Redox Regulation in Cancer A Double-edged Sword with Therapeutic Potentialdoc》,可适用于高等教育领域,主题内容包含RedoxRegulationinCancerADoubleedgedSwordwithTherapeuticPotentialREVIEWREVI符等。

RedoxRegulationinCancerADoubleedgedSwordwithTherapeuticPotentialREVIEWREVIEWOxidativeMedicineandCellularLongevity,:JanuaryFegruaryLandefBhifjhenjeRedoxregulationincancerAdoubleedgedswordwiththerapeuticpotentialAshaAcharya,*IlaDas,DesChandhokandTapasSaha*,,,LombardiComprehensiveCancerCenterPreClinicalScienceWashingtonDC,USAChittaranjanNationalCancerInstituteKolkata,IndiaGeneTarnCorporationRockville,USAKeywords:ROS,antioxidants,cancerstemcells,NRF,NF,B,BRCA,phaseII,detoxificationenzymesAbbreviations:DMBA,dimethylbenzaanthraceneGPx,glutathioneperoxidaseGST,glutathioneStransferaseSOD,superoxidedismutaseHO,heamoxygenaseER,estrogenreceptorPR,progesteronereceptorLPS,lipopolysaccharideTNF,tumornecrosisfactorGCL,glutamatecysteineligaseSAPK,stressactivatedproteinkinaseJNK,JunaminoterminalkinasePMA,phorbolmyristateacetateNQO,NAD(P)HquinoneoxidoreductaseARE,antioxidantresponseelementTRX,thioredoxinsGRX,glutaredoxinsstressinsearchforthecureofcancerInthebeginning,cancerOxidativestress,implicatedintllinesRev:PoolZobelB,VeeriahS,BohmerFDModulationCancerRes:SheweitaSA,TilmisanyAKCancerandphaseIIofxenobioticmetabolisingenzymesbyanticarcinoRazandiM,PedramA,RosenEM,LevinERdrugmetabolizingenzymesCurrDrugMetabgensfocusonglutathioneStransferasesandtheirBRCAinhibitsmembraneestrogenandgrowth:roleastargetsofdietarychemopreventionincolorecfactorreceptorsignalingtocellproliferationinbreastVaqueroEC,EdderkaouiM,PandolSJ,GukovskyI,talcarcinogenesisMutatRes:cancerMolCellBiol:GukovskayaASReactiveoxygenspeciesproducedBarveA,KhorTO,NairS,ReuhlK,SuhN,ReddyCavalieriE,ChakravartiD,GuttenplanJ,HartbyNAD(P)HoxidaseinhibitapoptosisinpancreaticB,etalGammatocopherolenrichedmixedtocophE,IngleJ,JankowiakR,etalCatecholestrogencancercellsJBiolChem:eroldietinhibitsprostatecarcinogenesisinTRAMPquinonesasinitiatorsofbreastandotherhumanVizanP,AlcarrazVizanG,DiazMoralliS,SolovjevamiceIntJCancer:cancers:implicationsforbiomarkersofsusceptibilityON,FrederiksWM,CascanteMModulationofKumaraguruparanR,SeshagiriPB,HaraY,NaginiandcancerpreventionBiochimBiophysActapentosephosphatepathwayduringcellcycleprogresSChemopreventionofratmammarycarcinogenesis:sioninhumancolonadenocarcinomacelllineHTbyblackteapolyphenols:modulationofxenobioticMitraPS,BasuNK,OwensISSrcsupportsUDPIntJCancer:metabolizingenzymes,oxidativestress,cellproliferaglucuronosyltransferaseBdetoxificationofcateInokumaT,HaraguchiM,FujitaF,TajimaY,tion,apoptosisandangiogenesisMolCarcinogcholestrogensassociatedwithbreastcancerBiochemKanematsuTOxidativestressandtumorprogression:BiophysResCommun:incolorectalcancerHepatogastroenterologyLeeSB,KimCY,LeeHJ,YunJH,NhoCWDabrosinC,HammarM,OllingerKImpactof:InductionofthePhaseIIDetoxificationEnzymeoestradiolandprogesteroneonantioxidantactivityinHuangF,NieC,YangY,YueW,RenY,ShangY,etNQOinHepatocarcinomaCellsbyLignansfromnormalhumanbreastepithelialcellsincultureFreealSeleniteinducesredoxdependentBaxactivationtheFruitofSchisandrachinensisthroughNuclearRadicRes:andapoptosisincolorectalcancercellsFreeRadicAccumulationofNrfPlantaMed:BiolMed:MobleyJA,BrueggemeierRWEstrogenreceptorNairS,LiW,KongANNaturaldietaryanticancermediatedregulationofoxidativestressandDNARosenEM,FanS,IsaacsCBRCAinhormonalchemopreventivecompounds:redoxmediateddifdamageinbreastcancerCarcinogenesis:carcinogenesis:basicandclinicalresearchEndocrferentialsignalingmechanismsincytoprotectionofRelatCancer:normalcellsversuscytotoxicityintumorcellsActaRaoA,ZieglerY,McLeodI,YatesJ,NardulliARosenEM,FanS,PestellRG,GoldbergIDBRCAPharmacolSin:ThioredoxinandthioredoxinreductaseinfluencegeneinbreastcancerJCellPhysiol:NaithaniROrganoseleniumcompoundsincanestrogenreceptor{alpha}mediatedgeneexpressioncerchemopreventionMiniRevMedCheminhumanbreastcancercellsJMolEndocrinolBaeI,FanS,MengQ,RihJK,KimHJ,KangHJ,::etalBRCAinducesantioxidantgeneexpressionFearonIM,FauxSPOxidativestressandcardiovasBenzCC,AtsrikuC,YauC,BrittonD,SchillingB,andresistancetooxidativestressCancerResculardisease:noveltoolsgive(free)radicalinsightJGibsonBW,etalNovelpathwaysassociatedwith:MolCellCardiol:quinoneinducedstressinbreastcancercellsDrugCaoL,XuX,CaoLL,WangRH,CoumoulX,OkamuraDM,HimmelfarbJTippingtheredoxMetabRev:KimSS,etalAbsenceoffulllengthBrcasensibalanceofoxidativestressinfibrogenicpathwaysinYauC,BenzCCGenesresponsivetobothoxidanttizesmicetooxidativestressandcarcinogeninducedchronickidneydiseasePediatrNephrol:stressandlossofestrogenreceptorfunctionidentifytumorigenesisintheesophagusandforestomachReddyVP,ZhuX,PerryG,SmithMAOxidativeapoorprognosisgroupofestrogenreceptorpositiveCarcinogenesis:stressindiabetesandAlzheimer’sdiseaseJAlzheimersprimarybreastcancersBreastCancerResXuX,QiaoW,LinkeSP,CaoL,LiWM,FurthPA,Dis::etalGeneticinteractionsbetweentumorsuppressorsWellsPG,McCallumGP,ChenCS,HendersonJT,KatiyarP,MaY,FanS,PestellRG,FurthPA,RosenBrcaandpinapoptosis,cellcycleandtumorigenLeeCJ,PerstinJ,etalOxidativestressindevelopEMRegulationofprogesteronereceptorsignalingesisNatGenet:mentaloriginsofdisease:teratogenesis,neurodebyBRCAinmammarycancerNuclReceptSignalSah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