基团,试剂的英文简称,全称,结构及用途

©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukAbbreviationFullNameSomeUsesStructuresAcAcetylVerycommonprotectinggroupforalcoholsandphenolsROAdAdamantylProtectinggroupforacids,thiolsandalcoholsRADAsymmetricdihydroxylationOHHONHNOHOOClOsO4+NMO+AEAsymmetricepoxidationSharplessConditionsOHOOHHCO2EtOHEtO2CHOHtBuOOH+Ti(OiPr)4+AIBN?,?'-AzoisobutyronitrileMakesradicalsNCNNCNAldrithiol®2,2'-DipyridyldisulphideThiolatingReagentNSSNAllAllylProtectinggroupforphenols,acidsandalcoholsespeciallycarbohydratesRAllocAllyloxycarbonylProtectinggroupforalcohols,aminesOOR9-BBN9-BorabicyclononaneHinderedreductantBBNBHBMSBorane-methylsulphidecomplexReducingagentBH3SMe2BINAP2,2'-Bis(diphenylphosphino)-1,1'-binapthylLigandforRucatalytichydrogenationandBuchwaldreactionPPh2PPh2BINAPOPhosphinousacid,diphenyl-[1,1'-binapthalene]-2-2'-diylesterLigandforRucatalytichydrogenationOPPh2OPPh2Boctert-ButoxycarbonylProtectinggroupforaminesespeciallypeptidesOORBOMBenzyloxymethylProtectinggroupforalcohols,phenols,acidsandaminesORBOPBenzotriazol-1-yloxytris(dimethylamino)phosphoniumhexafluorophospatePeptidecouplingreagentNNNPNNNPF6©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukBOP-ClBis(2-oxo-3-oxazolidinyl)phosphinicchloridePeptidecouplingreagentONPNClOOOOBnBenzylProtectinggroupforalcohols,phenols,acids,amides,aminesandcarbonylsRBrBrosylate,BromobenzenesulphonylActivatinggroupforalcoholsBrSOORBTAFBenzyltrimethylammoniumfluorideFluoratingreagentNFBumt-butoxymethylProtectinggroupforamines,alcoholsORBzBenzoylProtectinggroupforthiols,alcohols,phenolsmuchmorestablethanacetateORBHTtert-ButylhydroxytolueneStablizerforethersOHCANCericammoniumnitrateOxidisingagent(NH4)2[Ce(NO2)6]CBSCorey-Bashki-ShibatChiralreducingagentforcarbonylsNOBPhPhHBH3+CbzorZBenzyloxycarbonylVerycommonprotectinggroupforaminesespeciallyinaminoacidsOROCODCyclooctadieneLigandfortransitionmetalcatalystsandusedtomake9-BBNCpCyclopentadienylAsit’sanionaligandfortransitionmetalsandacommonDiels-AlderDienemCPBAmeta-chloroperoxybenzoicacidOxidisingagentusedformakingepoxidesandBaeyer-VilligerreactionOOOHCl18-Crown-6(18C6)1,4,7,10,13,16-hexaoxocyclooctadecanePhasetransfercatalystOOOOOOCSACamphorsulphonicacidChiralresolvingagentOHO3SH2CCysCystineAminoacidNH2OOHHS©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukDabco™1,4-Diazabicyclo[2.2.2]octaneStronghinderedbaseNNDASTDiethylaminosuphurtrifluorideFluorinatingagentNSFFFdbaDibenzylideneacetoneZ,Z-1,5-diphenyl-1,4-pentadien-3-oneLigandforpalladiumODBN1,5-Diazabicycolo[4.3.0]non-5-eneStronghinderedbaseNNDBU1,8-Diazabicyclo[5.4.0]undec-7-eneStronghinderedbaseNNDCC1,3-DicyclohexylcarbodiimidePeptidecouplingreagentNCNDDQ2,3-Dichloro-5,6-dicyano-1,4-benzoquinoneOxidantOOClClCNCNDEADDiethylazodicarboxylateReagentusedinMitsunobuReaction(inversionofalcohols)NONODHPDihydropyranThereagentusedtomakeTHPprotectedalcohols,acidsandphenols.ODHQDDihydroquinidineChiralligandNHNOHHODIADDiisopropylazodicarboxylateReagentusedinMitsunobuReaction(inversionofalcohols)NNOODIBALDIBAL-HDiisobutylaluminiumhydrideReducingagentfortheselectivereductionofestertoaldehydesAlHDICDiisopropylcardodiimidePeptidecouplingreagentCNNDIPEADIEADiisopropylethylamineProtonsponge,baseNDMDDimethyldioxoraneUsedformakingepoxidesOODMAP4-DimethylaminopyridineWeakbaseNNDMEDimethoxyethaneSolventOODMFN,N-DimethylformamideSolventON©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukDMPDess-MartinperiodateFromIodobenzoicacidheatwithAcOHthenAcO2MildoxidizingagentforalcoholstoaldehydesIOOAcOOAcOAcDMPM3,4-DimethoxybenzylProtectinggroupforalcohols(canberemovedinpresenceofMPMselectively)ROODMPU1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinoneNoncarcinogenicreplacementforHMPANNODMSDimethylsulphideUsedforquenchingOzonolysisandligandforBH3SDMSODimethylsulphoxideSolventandoxidantSODPPADiphenylphosphorylazideOrganicSourceofAzideOPOONNNEDCI1-ethyl-3-[3-(dimethylamino)propyl]carbodiimideReagentusedinMitsunobuReaction(inversionofalcohols)CNNNEDTAEthylenediamminetetraaceticacidChelatingagentformetalions.NNOOHOHOHOOOOHEE1-EthoxyethylProtectinggroupforaminesandalcoholsORFDPPPentafluorophenyldiphenylphosphinatePeptidecouplingreagentPOPhPhFFFFFFmoc9-FluorenylmethoxycarbonylProtectinggroupforamines,alcoholsandacids(verystabletoacids)OORHATUO-(7-azabenzotrizol-1-yl)-1,1,3,3,tetramethyluroniumhexafluorophosphateN-[(dimethylamino)-1H-1,2,3-triazol[4,5-b]pyridiylmethylene]-N-methylmethanaminiumhexafluorophosphateN-oxidePeptidecouplingagentNNNNNNOPF6HMPAHexamethylphosphoramdeCo-solventOPNNNHMPTHexamethylphoroustriamideCo-solventPNNN©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukHOBt1-hydroxbenzotriazolePeptidecouplingagentNNNOHImImidazoleBaseusedinsilylationsNNHIpcIsopinocampheylChiralligandusuallyattachedtoboronforasymmetrichydroborationsRKDAPotassiumdiisopropylamideNon-NucelophillicBaseNKKHMDSPotassiumbis(trimethylsilyl)amideNon-NucelophillicBaseKSiNSiK-Selectride®Potassiumtri-sec-butylborohydrideStereoselectivereductantviachelationcontrolKBHLDALithiumdiisopropylamideNon-NucelophillicBaseNLiLDEALithiumdiethylamideStrongBaseNLiLiHMDSLithiumbis(trimethylsilyl)amideNon-NucelophillicBaseSiNSiLiMEM2-MethoxyethoxymethylProtectinggroupforalcoholsandphenols(morestablethanMOM)OORMOMMethoxymethylProtectinggroupforalcoholsandphenolsORMozorMeOZp-MethoxybenzylcarbonylProtectinggroupforaminesOOOR2NMPMp-MethoxybenzylProtectinggroupforalcoholsandphenols(moreeasilyoxidativlycleaved)RO3,4,5ÅMSMolecularsievesBeadsforabsorbingtypicallywaterMsMethanesulphonylActivatinggroupalcoholsSROOMSAMethanesulfonicacidVerystrongorganicacidSOHOOMWMicrowaveEnergysourceforreactionsNaHMDSSodiumbis(trimethylsilyl)amideNon-NucelophillicBaseSiNSiNa©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukNBSN-BromosuccinimideRadicalBrominatingagentNOOBrNISN-IodosuccinimideRadicalIodinatingagentNOOINMMN-MethylmorpholineBaseONNMON-Methylmorpholine-N-oxideCo-OxidantONON-PSPN-PhenylselenophtalimideElectrophillicsourceofphenylselanideNOOSeNpso-NitrophenylsulphonylProtectinggroupforamines(easertocleavethanTs)SOORNO2Oxone®PotassiumperoxoymonosulfateOxidant2KHSO5.KHSO4.K2SO4PDCPyridiniumdichromateOxidantforalcoholstoaldehydesandketonesNH2Cr2O72-PCCPyridiniumchlorochromateOxidantforalcoholstoaldehydesandketonesNHClCrO3-PhPhenylProtectinggroupforacids,thiolsRPivPvPivaloylProtectinggroupforalcoholsandphenolsOORPMBp-MethoxybenzylProtectinggroupforamines,amides,alcohols,phenolsandacidsROPMPp-MethoxyphenylProtectinggroupforalcoholsORPPAPolyphosphoricacidStrongdehydratingagentPOOHOHOxPPTSPyridiniump-toluenesulphoateVeryweakacid,usedtoaddanexactamountofacidasit’sasolidSOOOHNPTSAp-TsOHp-ToluenesulphonicacidStrongorganicacidSOOOHPyPyridineWeakorganicbaseN©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukPyBroPBromotripyrrolidinophosphoniumhexafluorophosphatePeptidecouplingreagentNPNNBrF6PSEM[2-(trimethylsilyl)ethoxy]methylProtectinggroupforamines,alcohols,phenols,acidsSiRSEMCl[2-(trimethylsilyl)ethoxy]methylchlorideThereagentusedtoprovidetheaboveprotectionSiOClRed-Al®Sodiumbis(2-methoxyethoxy)aluminiumhydrideVersatileReductant(moresolubleatlowtemperatures)AlOOOOHHNaTBAFTetrabutylammoniumfluorideFluorinatingagentBu4NFTBDMStert-ButyldimethylsilylVerypopularprotectinggroupforalcohols,phenols,thiolsandamines(1000xmorestablethanTMS)SiRTBDPStert-ButyldiphenylsilylProtectinggroupforalcoholsandamines(100xmorestablethanTBDMS)SiRTBStert-ButylmethylsilylVerypopularprotectinggroupforalcohols,phenols,thiolsandamines(1000xmorestablethanTMS)SiRTBTUO-Benzotriazol-1-yl-N,N,N',N'-tetramethyluroniumtetrafluoroboratePeptidecouplingreagentNNNONNBFFFFTCDIThiocarbonyldiimidazoleUsedinradicaldecarboxylationSNNNNTEATriethylamideBaseNTEMPO2,2,6,6-tetramethyl-1-piperdinyloxyfreeradicalStableradicaloxidantandinitiatorNOTfTrifluoromethanesulphonylTriflateActivatingagentforalcoholsandphenolsinPalladiumcatalysedcouplings.AlsoprotectinggroupforaminesSOOFFFRTFATrifluoroaceticacid/TrifluoroacetylVerystrongorganicacidusedinsolidphasesynthesisforcleavingfromresinandusedtoremovemanyprotectinggroupsOOHFFFTFAATrifluoroaceticanhydrideUsedtomakeprotectedaminesandalcohols(veryeasilycleaved,seeTFA)F3COOOF3C©2000TobyBroomNopartofthisdocumentmaybereproducedormodifiedwithouttheexpresspermissionofTobyBroom.tbroom@totalise.co.ukTHPTetrahydropyranProtectinggroupforalcohols,acidsandphenolsPreparedfromDHPOORTIPSTriisopropylsilylProtectinggroupforalcoholsandamines(stabilitybetweenTBDMSandTBDPS)SiRTMGTetramethylguanidineBaseNNNHTMSTrimethylsilylProtectinggroupforalcohols,amines,aminoacids,acids,phenolsandthiols(probablythemostcommonprotectinggroup)SiRTMSClTrimethylsilylchlorideOneofthereagentusedtoprovidetheaboveprotectionSiClTMSOTfTrimethylsilyltrifluoromethanesulfonateLewisAcid,typicallyusedformakingsilylenolethersSOOFFFSiTolp-ToluylProtectinggroupforacids,thiolsRo-Tolylo-ToluylProtectinggroupforacids,thiolsRTPAPTetra-n-propylammoniumperruthenateOxidantPr4NRuO4TrTritylProtectinggroupforamines,alcohols,amidesandthiolsCRTroc2,2,2-TrichlorethoxycarbonylProtectinggroupforthiols,phenolsOClClClORTsp-Toluenesulphonyl,TosylActivatinggroupforalcoholsandprotectinggroupforaminesSOORVitride®Sodiumbis(2-methoxyethoxy)aluminumhydrideVersatileReductant(moresolubleatlowtemperatures)AlOOOOHHNaZorCbzBenzyloxycarbonylVerycommonprotectinggroupforaminesespeciallyinaminoacidsOOR