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首页 Microfabrication in Biology and medicine

Microfabrication in Biology and medicine.ppt

Microfabrication in Biology and…

中小学精品课件
2019-05-19 0人阅读 举报 0 0 0 暂无简介

简介:本文档为《Microfabrication in Biology and medicineppt》,可适用于工程科技领域

MicrofabricationinBiologyandMedicine班王梦乔AnnuRevBiomedEng:–AuthorJoelVoldmanMarthaLGrayandMartinASchmidtDepartmentofElectricalEngineeringandComputerScience,MicrosystemsTechnologyLaboratories,andDivisionofHealthSciencesandTechnology,MassachusettsInstituteofTechnology,Cambridge,KeyWordsmicromachining,microelectromechanicalsystems,cellbiologymolecularbiology,MEMSAbstractTheMicrofabricationapplicationsfallintofourdomains:toolsformolecularbiologyandbiochemistry,toolsforcellbiology,medicaldevices,andbiosensorsWedescribemicrofabricationtechnologyanditsapplicationtobiologyandmedicineCONTENTSIntroductionMicrofabricationTechnologyApplicationsOverviewAdvantagesConferredbyMicrofabricationConclusionsIntroductionMicrofabricationisaprocessusedtoconstructphysicalobjectswithdimensionsinthemicrometertomillimeterrangeMicrofabricatedobjectsordevicescanbecomprisedofarangeofminiaturestructures,includingmovingpartssuchascantileversanddiaphragms,staticstructuressuchasflowchannelsmicrofabricationcaneithersignificantlyenhanceadeviceinrelationtoitsconventionalcounterpartorenableentirelynewdevicesExampleSchematicofflowchambermicrofabricatedinsiliconMicrofabricationTechnologyFourbasicprocesses:photolithographythinfilmdepositionEtchingbondingSubstrateMaterialsSilicon:excellentelectricalpropertiesmechanicalpropertiesGlass:Itcouldprovidesomeuniquefeatures,mostnotablyopticaltransparencyPlastics:inexpensivePhotolithographyPhotolithographyisusedtotransferapatternenvisionedbythedesignerintoamaterialPatterntransferwithphotolithographyThinFilmGrowthDepositionDielectricsSiliconMetalsPlasticsBiomoleculesEtchingWet(vialiquidchemicals)anddry(viagasphasechemistry)etchingThinFilmsSiliconGlassPlasticsSampleProcessFlowAPPLICATIONSOVERVIEWfourdomains:toolsformolecularbiologyandbiochemistrytoolsforcellbiologytoolsformedicinetoolsforbiosensorsMicrofabricateddeviceswithapplicationsinmolecularbiologyandbiochemistryMicrofabricateddeviceswithapplicationsinvolvingcellsorcellbiologyMicrofabricateddeviceswithapplicationsinmedicineADVANTAGESCONFERREDBYMICROFABRICATIONSmallDeviceSizeHighSurfaceAreatoVolumeRatioIntegrationwithElectronicsHighThroughputSmallSampleVolumesBatchProcessingGeometricalControlConstrainedGeometriesSingleCellAnalysisDisadvantagesofMicrofabricationlongdevelopmenttimestherangeofstructuresormaterialsavailablemightnotbecompatiblewiththeapplicationCONCLUSIONSWhenusedappropriately,itcansignificantlyimpactcurrentbiologicalormedicalproblemsMicrofabricationtechnologyismeanttosupplement,notreplace,theseestablishedtechnologiesInthefuture,therewillbemorecooperationbetweenmicrofabricationandbiologyandmedicine

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