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首页 MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会减轻损害

MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会减轻损害.doc

MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会…

Janice彩菊
2019-02-09 0人阅读 举报 0 0 暂无简介

简介:本文档为《MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会减轻损害doc》,可适用于医药卫生领域

MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会减轻损害肝豆状核变性又称威尔逊病是一种常染色体隐性遗传的铜代谢障碍疾病由于铜在体内过度蓄积损害肝、脑等器官而致病。临床主要表现之一即为神经系统症状。T加权成像显示基底节、脑干或丘脑信号强度减低。早期确诊治疗本病可使预后大为改观。那么发病多长时间内进行治疗可更有效减轻大脑实质不可逆性损害呢?为解答这一问题。塞尔维亚NoviSad大学医学院DukoBKozi所在团队应用MRI研究螯合治疗肝豆状核变性过程中患者大脑损害恢复情况并探讨疾病首发后开始治疗的最佳时机。对例肝豆状核变性患者进行首次MRI检查其中例在平均年后进行MRI复查。发病后个月内进行治疗的患者脑干和壳核损害恢复情况明显好于发病≥个月时开始进行治疗者髓鞘溶解和细胞毒性脑水肿也更为轻微。说明应在肝豆状核变性发病后个月内进行螯合治疗可减少大脑实质可逆性损害的发生。相关文章发表于《中国神经再生研究(英文版)》杂志年月第期。Article:"ReversiblelesionsinthebrainparenchymainWilson’sdiseaseconfirmedbymagneticresonanceimaging:earlieradministrationofchelatingtherapycanreducethedamagetothebrain"byDukoBKozi,IgorPetrovi,MarinaSvetel,TatjanaPekmezovi,AleksandarRagaji,VladimirSKosti(DiagnosticImagingCenter,InstituteofOncology,SchoolofMedicine,UniversityofNoviSad,PutDoktoraGoldmana,SremskaKamenica,SerbiaInstituteofNeurologyClinicalCentreofSerbia,SchoolofMedicine,UniversityofBelgrade,DrSubotia,,Belgrade,SerbiaInstituteofEpidemiology,SchoolofMedicine,UniversityofBelgrade,DrSubotia,,Belgrade,Serbia)KoziDB,PetroviI,SvetelM,PekmezoviT,RagajiA,KostiVSReversiblelesionsinthebrainparenchymainWilson’sdiseaseconfirmedbymagneticresonanceimaging:earlieradministrationofchelatingtherapycanreducethedamagetothebrainNeuralRegenRes():欲获更多资讯:NeuralRegenResEarlychelatingtherapyreducesreversiblelesionstothebraininWDasconfirmedbyMRIWilson'sdisease(WD)isarareinheriteddisorderthatcausestoomuchcoppertoaccumulateinyourliver,brainandothervitalorgansItmanifestsasneurologicalsymptomsTweightedimagesshowdecreasedsignalintensityinthebasalganglia,brainstemorthalamusEarlydiagnosisandtreatmentcangreatlyimprovetheprognosisAtwhattimeafterdiseaseonsetdoesthetreatmentcangreatlyreducereversiblelesionsinthebrainparenchymainWilson’sdiseaseTosolvethisproblem,DukoBKozi,InstituteofOncology,SchoolofMedicine,UniversityofNoviSad,SerbiaandhiscolleaguesobservedtherecoveryfromcerebralinjuriesinpatientswithWDafteradministrationofchelatingtherapyusingMRIexaminationandsimultaneouslyinvestigatedtheoptimaltreatmenttimeaftertreatmentInitialMRIexaminationwasperformedinpatientsandMRIwasperformedagaininofthemafteranaverageofyearsTherecoveryoflesionsinthebrainstemandputaminallesionswassuperiorto,themyelinolisisorcytotoxicedemawasmilder,inpatientswhoreceivedchelatingtherapystarting<monthsfromthefirstsymptomsandinthosewhoreceivedchelatingtherapystarting≥monthsaftertheinitialsymptomsChelatingtherapyshouldbestartedlessthanmonthsafteronsetofthesymptoms,whichcangreatlyreducethereversiblelesionsinthebrainparenchymaTheseresultswerepublishedinNeuralRegenerationResearch(Vol,No,)Article:"ReversiblelesionsinthebrainparenchymainWilson’sdiseaseconfirmedbymagneticresonanceimaging:earlieradministrationofchelatingtherapycanreducethedamagetothebrain"byDukoBKozi,IgorPetrovi,MarinaSvetel,TatjanaPekmezovi,AleksandarRagaji,VladimirSKosti(DiagnosticImagingCenter,InstituteofOncology,SchoolofMedicine,UniversityofNoviSad,PutDoktoraGoldmana,SremskaKamenica,SerbiaInstituteofNeurologyClinicalCentreofSerbia,SchoolofMedicine,UniversityofBelgrade,DrSubotia,,Belgrade,SerbiaInstituteofEpidemiology,SchoolofMedicine,UniversityofBelgrade,DrSubotia,,Belgrade,Serbia)KoziDB,PetroviI,SvetelM,PekmezoviT,RagajiA,KostiVSReversiblelesionsinthebrainparenchymainWilson’sdiseaseconfirmedbymagneticresonanceimaging:earlieradministrationofchelatingtherapycanreducethedamagetothebrainNeuralRegenRes():

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MRI研究证实肝豆状核变性脑实质可逆性损害:早期开始螯合治疗会减轻损害

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