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首页 LOTUS对抗Nogo受体-1抑制轴突生长的可能性验证

LOTUS对抗Nogo受体-1抑制轴突生长的可能性验证.doc

LOTUS对抗Nogo受体-1抑制轴突生长的可能性验证

周君萍
2019-02-09 0人阅读 举报 0 0 0 暂无简介

简介:本文档为《LOTUS对抗Nogo受体-1抑制轴突生长的可能性验证doc》,可适用于医药卫生领域

LOTUS对抗Nogo受体抑制轴突生长的可能性验证神经胶质细胞来源的神经轴突生长抑制蛋白会限制成人中枢神经系统损伤后的功能性修复。Nogo蛋白质、髓鞘相关糖蛋白、少突胶质细胞髓鞘糖蛋白和B淋巴细胞刺激因子这种抑制剂通常有神经元受体Nogo受体相互作用从而会抑制轴突生长。日本横滨市立大学KohtaroTakei教授证实了外侧嗅束引导物质(LOTUS)结合NgR会妨碍种NgR配体的结合因而减弱NgR配体诱导的轴突生长抑制。LOTUS使神经元有能力克服NgR介导的轴突生长抑制在未来LOTUS可能会是促进神经元再生的有效内源性NgR抑制剂。年月第期《中国神经再生研究(英文版)》杂志上。与Nogo信号相关的分子机制示意图Article:"LOTUS,apotentblockerofNogoreceptorcausinginhibitionofaxonalgrowth"byYujiKurihara,KohtaroTakei(MolecularMedicalBioscienceLaboratory,DepartmentofMedicalLifeScience,YokohamaCityUniversityGraduateSchoolofMedicalLifeScience,Suehirocho,Tsurumiward,Yokohama,Japan)KuriharaY,TakeiK()LOTUS,apotentblockerofNogoreceptorcausinginhibitionofaxonalgrowthNeuralRegenRes():欲获更多资讯:NeuralRegenResLOTUS,apotentblockerofNogoreceptorcausinginhibitionofaxonalgrowthGliaderivedaxonalgrowthinhibitoryproteinslimitfunctionalrepairfollowingdamagetotheadultcentralnervoussystem(CNS)Nogoproteins,myelinassociatedglycoprotein(MAG),oligodendrocytemyelinglycoprotein(OMgp)andBlymphocytestimulator(BLyS),areinhibitorsthatcommonlyinteractwiththeneuronalreceptor,Nogoreceptor(NgR),leadingtoinhibitionofaxonalgrowthHere,ProfKohtaroTakei,whocomesfromYokohamaCityUniversityGraduateSchoolofMedicalLifeScience,Japandemonstratethatlateralolfactorytractushersubstance(LOTUS)bindstoNgRandblocksthebindingofallfourligandstoNgR,resultinginthesuppressionofaxonalgrowthinhibitioninducedbytheseNgRligandsLOTUSallowsneuronstoovercomeNgRmediatedaxonalgrowthinhibition,raisingthepossibilitythatLOTUSmaybeusefulinfuturetherapeuticapproachesasanendogenouspotentinhibitorofNgRforpromotingneuronalregenerationTherelevantstudyhasbeenpublishedintheNeuralRegenerationResearch(Vol,No,)SchematicdrawingofmolecularmechanismassociatedwithNogosignalingArticle:"LOTUS,apotentblockerofNogoreceptorcausinginhibitionofaxonalgrowth"byYujiKurihara,KohtaroTakei(MolecularMedicalBioscienceLaboratory,DepartmentofMedicalLifeScience,YokohamaCityUniversityGraduateSchoolofMedicalLifeScience,Suehirocho,Tsurumiward,Yokohama,Japan)KuriharaY,TakeiK()LOTUS,apotentblockerofNogoreceptorcausinginhibitionofaxonalgrowthNeuralRegenRes():

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