Synera™ (lidocaine 70 mg and tetracaine 70 mg) topical patch

1 Synera™ (lidocaine 70 mg and tetracaine 70 mg) topical patch DESCRIPTION Synera™ consists of a thin, uniform layer of a local anesthetic formulation with an integrated, oxygen-activated heating component that is intended to enhance the delivery of the local anesthetic. The drug formulation is an emulsion in which the oil phase is a eutectic mixture of lidocaine 70 mg and tetracaine 70 mg. The eutectic mixture has a melting point below room temperature and therefore exists as a liquid oil rather than as crystals. The surface area of the entire Synera patch is approximately 50 cm2, 10 cm2 of which is active. Lidocaine is chemically designated as acetamide, 2- (diethylamino)-N-(2,6-dimethylphenyl), has an octanol:water partition ratio of 182 at pH 7.3 and has the following structure: Tetracaine is chemically designated as 2-(dimethylamino)ethyl p- (butylamino)benzoate, has an octanol:water partition ratio of 5370 at pH 7.3 and has the following structure: Each Synera patch contains lidocaine 70 mg and tetracaine 70 mg in a eutectic mixture. The Synera formulation also contains the following inactive ingredients: polyvinyl alcohol, sorbitan monopalmitate, water, methylparaben and propylparaben. The Synera heating component generates a mild warming that is intended to enhance the delivery of the local anesthetic. Synera begins to heat once the patch is removed from the pouch and is CH3 NHCOCH2N(C2H5)2 CH3 COOCH2CH2N(CH3)2 CH3(CH2)3NH 2 exposed to oxygen in the air. Although the patch may increase skin temperature by up to approximately 5ºC, maximum skin temperature will not exceed 40ºC. The heating component is composed of iron powder, activated carbon, sodium chloride, wood flour, water and filter paper. CLINICAL PHARMACOLOGY Mechanism of Action: Synera™ applied to intact skin provides local dermal analgesia by the release of lidocaine and tetracaine from the patch into the skin. Lidocaine is an amide-type local anesthetic agent and tetracaine is an ester-type local anesthetic agent. Both lidocaine and tetracaine block sodium ion channels required for the initiation and conduction of neuronal impulses, resulting in local anesthesia. Pharmacokinetics: Absorption: The amount of lidocaine and tetracaine systemically absorbed from Synera is thought to be directly related to the duration of application. However, this was not clearly demonstrated in clinical trials. Application of one Synera patch for 30 minutes in adults produced peak plasma concentrations of lidocaine less than 5 ng/mL while plasma levels of tetracaine were below the limit of quantitation (<0.9 ng/mL) in all subjects tested (n = 12, see Table 1). Synera application up to 60 minutes did not significantly increase plasma levels of lidocaine or tetracaine compared to a 30-minute application. Table 1 Absorption of Lidocaine and Tetracaine from Synera Normal Adult Volunteers (n = 12) Number of Synera Patches Age Range (yr) Application Time (min) Drug Content (mg) Estimated Amount Absorbed (mg) * Cmax (ng/mL) Tmax (hr) 1 18 - 65 30 Lidocaine, 70 1.7 1.7 1.7 Tetracaine, 70 1.6 < 0.9 na *Estimated absorbed dose was calculated by subtracting the residual amount of drug in each patch from the labeled claim. na = not applicable The surface area of application was 10 cm2 per Synera patch. 3 Application of Synera to broken or inflamed skin, or simultaneous or sequential application of multiple Synera patches could result in higher plasma levels of local anesthetic that could, in susceptible individuals, produce systemic toxicity. In general, application of multiple Synera patches either simultaneously or sequentially is not recommended. However, plasma levels of lidocaine and tetracaine have been determined in clinical pharmacology studies following multiple successive and simultaneous applications of Synera patches on intact skin. Maximum plasma levels of lidocaine after the application of a) four successive Synera patches for 30 minutes each with a 30- minute interval between each patch application, and b) three Synera patches for 60 minutes each with a 60-minute interval between each application were less than 12 ng/mL and 8 ng/mL, respectively. Tetracaine was not detected in plasma following either treatment. Simultaneous application of two or four Synera patches for 60 minutes produced peak plasma concentrations of lidocaine of less than 9 ng/mL, while tetracaine plasma concentrations were not detectable in all subjects (n=22). Sequential 30-minute applications of four Synera patches at 60-minute intervals produced peak plasma concentrations of lidocaine of less than 12 ng/mL, while tetracaine plasma concentrations were below the limit of quantitation (n=11). Distribution: When lidocaine is administered intravenously to healthy volunteers, the steady-state volume of distribution is approximately 0.8 to 1.3 L/kg. At lidocaine concentrations observed following the recommended product application, approximately 75% of lidocaine is bound to plasma proteins, primarily alpha-1-acid glycoprotein. At much higher plasma concentrations (1 to 4 mcg/mL of free base) the plasma protein binding of lidocaine is concentration dependent. Lidocaine crosses the placental and blood brain barriers, presumably by passive diffusion. CNS toxicity may typically be observed around 5000 ng/mL of lidocaine; however a small number of patients reportedly may show signs of toxicity at approximately 1000 ng/mL. Volume of distribution and protein binding have not been determined for tetracaine due to rapid hydrolysis in plasma. Metabolism: It is not known if lidocaine or tetracaine is metabolized in the skin. Lidocaine is metabolized rapidly by the 4 liver to a number of metabolites including monoethylglycinexylidide (MEGX) and glycinexylidide (GX), both of which have pharmacologic activity similar to, but less potent than that of lidocaine. The major metabolic pathway of lidocaine, sequential N-deethylation to monoethylglycinexylidide (MEGX) and glycinexylidide (GX), is primarily mediated by CYP1A2 with a minor role of CYP3A4. The metabolite, 2,6- xylidine, has unknown pharmacologic activity. Following intravenous administration of lidocaine, MEGX and GX concentrations in serum range from 11% to 36% and from 5% to 11% of lidocaine concentrations, respectively. Serum concentrations of MEGX were about one-third the serum lidocaine concentrations. Tetracaine undergoes rapid hydrolysis by plasma esterases. Primary metabolites of tetracaine include para-aminobenzoic acid and diethylaminoethanol, both of which have an unspecified activity. Elimination: The half- life of lidocaine elimination from the plasma following intravenous administration is approximately 1.8 hr. Lidocaine and its metabolites are excreted by the kidneys. More than 98% of an absorbed dose of lidocaine can be recovered in the urine as metabolites or parent drug. Less than 10% of lidocaine is excreted unchanged in adults, and approximately 20% is excreted unchanged in neonates. The systemic clearance is approximately 8-10 mL/min/kg. During intravenous studies, the elimination half- life of lidocaine was statistically significantly longer in elderly patients (2.5 hours) than in younger patients (1.5 hours). The half- life and clearance for tetracaine have not been established for humans, but hydrolysis in the plasma is rapid. Special Populations Pediatrics: Application of one Synera patch for up to 30 minutes in children 4 months to 12 years of age (n=18) produced maximum peak plasma concentrations of lidocaine and tetracaine of 63 ng/mL and 65 ng/mL, respectively. Application of two Synera patches for up to 30 minutes to children 4 months to 12 years of age (n=19) produced peak lidocaine levels of up to 331 ng/mL and tetracaine levels of less than 5 ng/mL. Elderly: After application of one Synera patch for 20 minutes, plasma levels of lidocaine and tetracaine were not detectable in 5 elderly subjects (> 65 years of age, mean 72.0 ±4.3 years, n=10). After simultaneous application of two Synera patches for 60 minutes to elderly subjects (> 65 years of age, mean 69.5 ±3.7 years, n=12), the maximum peak lidocaine concentration was 6 ng/mL and tetracaine was not detectable. During intravenous studies, the elimination half- life of lidocaine was statistically significantly longer in elderly patients (2.5 hours) than in younger patients (1.5 hours). Cardiac, Renal and Hepatic Impairment: No specific pharmacokinetic studies were conducted. The half- life of lidocaine may be increased in cardiac or hepatic dysfunction. There is no established half- life for tetracaine due to rapid hydrolysis in the plasma. CLINICAL STUDIES SUPERFICIAL VENOUS ACCESS Three randomized, double-blind, placebo controlled clinical trials in adult and geriatric subjects evaluated the degree of dermal analgesia upon venipuncture following a 20-minute treatment with Synera™ or a placebo patch (patch with heating component but no drug). In each trial, subjects received Synera on one arm and placebo patch on the other. Less pain was reported following Synera treatment compared to placebo in all three studies as measured by a 100 mm visual analog scale (VAS). In the first study in 21 subjects, median VAS scores for Synera and placebo treatments were 1 and 9, respectively. In the second study in 40 subjects, median VAS scores were 5 and 28 for Synera and placebo treatments, respective ly. In the third study, in 40 subjects over the age of 65 years, median VAS scores for Synera and placebo treatments were 8 and 14, respectively. In a randomized, double-blind, placebo controlled study, 61 pediatric patients received either Synera or placebo for 20 minutes prior to venipuncture or IV cannulation in the antecubital fossa or dorsum of the hand. Subjects were stratified by age group (3 to 6 years and 7 to 17 years). Children in the younger group reported less pain with Synera than with placebo, as rated using a six-point Oucher pain scale with faces. Children in the older group rated their pain using a different instrument; an eleven-point Oucher pain scale that contained both faces and numbers. Pain scores in the older children treated with Synera were not statistically significantly different from pain scores in those treated with placebo. 6 In a double-blind trial in 250 adults, subjects were randomized to receive either Synera without heating element or intact, heated Synera, prior to venipuncture. Less pain was reported following treatment with the heated Synera compared to the non-heated patch. Median VAS scores for the patch with the heating component and without the heating component were 17 and 22, respectively. SUPERFICIAL DERMATOLOGICAL PROCEDURES In one randomized, double-blind, placebo controlled study, 94 adult subjects received either Synera or placebo patch for 30 minutes prior to a superficial dermatological procedure such as superficial excision, shave biopsy or electrodessication. Less pain was reported following Synera treatment compared to placebo. Median VAS scores for Synera and placebo treatments were 5 and 31, respectively. In a similarly designed study in 74 subjects over the age of 65 years, less pain was reported following Synera treatment compared to placebo with median VAS scores for Synera and placebo treatments of 10 and 23, respectively. In a randomized, double-blind, placebo controlled study, 88 pediatric patients were stratified by age group (3 to 6 years and 7 to 17 years) to receive a 30-minute application of either Synera or placebo, prior to lidocaine injection. In younger children who used the Oucher pain scale with faces, those receiving Synera reported less pain from lidocaine injection than those receiving placebo. Older children used the numerical Oucher pain scale to report pain intensity. There was no difference between treatments observed in the older children. INDICATIONS AND USAGE Synera™ is indicated for use on intact skin to provide local dermal analgesia for superficial venous access and superficial dermatological procedures such as excision, electrodessication and shave biopsy of skin lesions (see CLINICAL STUDIES section). CONTRAINDICATIONS Synera™ is contraindicated in patients with a known history of sensitivity to lidocaine, tetracaine, or local anesthetics of the amide or ester type. Synera is also contraindicated in patients with para- aminobenzoic acid (PABA) hypersensitivity and in patients with a known history of sensitivity to any other component of the product. WARNINGS Application of Synera™ (lidocaine 70 mg and tetracaine 70 mg) topical patch for longer duration than recommended, or the 7 simultaneous or sequential application of multiple Synera patches, could result in sufficient absorption of lidocaine and tetracaine to result in serious adverse effects (see Overdosage). Even a used Synera patch contains a large amount of lidocaine and tetracaine (at least 90% of the initial amount). The potential exists for a child or pet to suffer serious adverse effects from chewing or ingesting a new or used Synera patch. It is important for patients to store and dispose of Synera out of the reach of children and pets. PRECAUTIONS General: Synera™ should be used with caution in patients who may be more sensitive to the systemic effects of lidocaine and tetracaine including the acutely ill or debilitated. Allergic or anaphylactoid reactions associated with lidocaine, tetracaine, or other components of Synera can occur. They are characterized by urticaria, angioedema, bronchospasm, and shock. If an allergic reaction occurs, it should be managed by conventional means. Contact of Synera with the eyes should be avoided based on the findings of severe eye irritation with the use of similar products in animals. Also, the loss of protective reflexes may predispose to corneal irritation and potential abrasion. If eye contact occurs, immediately wash out the eye with water or saline and protect the eye until sensation returns. Synera is not recommended for use on mucous membranes or on areas with a compromised skin barrier because these uses have not been adequately studied. Application to broken or inflamed skin may result in toxic blood concentrations of lidocaine and tetracaine from increased absorption. Patients with severe hepatic disease or pseudocholinesterase deficiency, because of their inability to metabolize local anesthetics normally, are at a greater risk of developing toxic plasma concentrations of lidocaine and tetracaine. Lidocaine has been shown to inhibit viral and bacterial growth. The effect of Synera on intradermal injections of live vaccines has not been determined. The integrated heating component contains iron powder, therefore, the Synera patch must be removed before a patient undergoes magnetic resonance imaging. 8 Information for patients: Patients should be aware that topical application of local anesthetics such as Synera may lead to diminished or blocked sensation in the treated skin. For this reason, patients should avoid inadvertent trauma to the treated area. Such trauma can result from scratching or rubbing before complete sensation has returned, or from exposure to extreme hot or cold temperatures. Drug Interactions: Antiarrhythmic Drugs: Synera should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the systemic toxic effects are thought to be additive and potentially synergistic with lidocaine and tetracaine. Local Anesthetics: When Synera is used concomitantly with other products containing local anesthetic agents, the amount absorbed from all formulations should be considered since the systemic toxic effects are thought to be additive and potentially synergistic with lidocaine and tetracaine. Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenesis: Long-term studies in animals have not been performed to evaluate the carcinogenic potential of either lidocaine or tetracaine. Mutagenesis : The mutagenic potential of lidocaine base and tetracaine base has been determined in the in vitro Ames Bacterial Reverse Mutation Assay, the in vitro chromosome aberration assay using Chinese hamster ovary cells, and the in vivo mouse micronucleus assay. Lidocaine was negative in all three assays. Tetracaine was negative in the in vitro Ames assay and the in vivo mouse micronucleus assay. In the in vitro chromosome aberration assay, tetracaine was negative in the absence of metabolic activation, and equivocal in the presence of metabolic activation. Impairment of Fertility: Lidocaine did not affect fertility in female rats when given via continuous subcutaneous infusion via osmotic minipumps up to doses of 250 mg/kg/day (1500 mg/m2 or 43-fold higher than the single dermal administration [SDA]). Although lidocaine treatment of male rats increased the copulatory interval and led to a dose-related decreased homogenization resistant sperm head count, daily sperm production, and spermatogenic efficiency, the treatment did not affect overall 9 fertility in male rats when given subcutaneous doses up to 60 mg/kg (360 mg/m2 or 8-fold the SDA). Tetracaine did not affect fertility in male or female rats when given subcutaneous doses up to 7.5 mg/kg (45 mg/m2 or 1-fold the SDA). Multiples of exposure are based on an SDA of 70 mg each of lidocaine and tetracaine in Synera for 30 minutes to a 60 kg person (43 mg/m2). Use in Pregnancy: Teratogenic Effects: Pregnancy Category B. Lidocaine was not teratogenic in rats given subcutaneous doses up to 60 mg/kg (360 mg/m2 or 8-fold the SDA) or in rabbits up to 15 mg/kg (180 mg/m2 or 4-fold the SDA). Tetracaine was not teratogenic in rats given subcutaneous doses up to 10 mg/kg (60 mg/m2 or 1-fold the SDA) or in rabbits up to 5 mg/kg (60 mg/m2 or 1-fold the SDA). Synera components (lidocaine and tetracaine) given as a 1:1 eutectic mixture was not teratogenic in rats (60 mg/m2 or 1-fold the SDA) or rabbits (120 mg/m2 or 3-fold the SDA). Nonteratogenic Effects: Lidocaine, contained 1:100,000 epinephrine, at a dose of 6 mg/kg (2-fold the SDA) injected into the masseter muscle of the jaw or into the gum of the lower jaw of Long-Evans hooded pregnant rats on gestation day 11 lead to developmental delays in neonatal behavior among offspring. Developmental delays were observed for negative geotaxis, static righting reflex, visual discrimination response, sensitivity and response to thermal and electrical shock stimuli, and water maze acquisition. The developmental delays of the neonatal animals were transient with responses becoming comparable to untreated animals later in life. The clinical relevance of the animal data is uncertain. Pre- and postnatal maturational, behavioral, or reproductive development was not affected by maternal subcutaneous administration of tetracaine during gestation and lactation up to doses of 7.5 mg/kg (45 mg/m2 or 1-fold the SDA). No adequate and well-controlled studies have been conducted in pregnant women. Because animal studies are not always predictive of human response, Synera should be used during pregnancy only if the potential benefit justifies risk to the fetus. Labor and Delivery: Neither lidocaine nor tetracaine is contraindicated in labor and delivery. In humans, the us