Additional file 2 Alignment of protein sequences used in ：附加文件2中使用的蛋白质序列比对

Additional file 2 Alignment of protein sequences used in ：附加文件2中使用的蛋白质序列比对 Additional file 2: Alignment of protein sequences used in phylogenetic analysis. Alignment done in MUSCLE. FucD ----------------------MRTIIALETHDVRFPTSRELDGSD-----AM----NPD C.intestinalis -------------------MEVTGKITKIDVCDVRFPTSLEHHGSD-----AM----HGE C.savignyi ---------------------ISGKITEVKVRDIRFPTSLEHHGSD-----AM----HGE Rattus ------------------------------------------------------------ Xenopus --------------------MITGTITSLHVTDVRFPTSLDQHGSD-----AM----HTD Anolis --------------------MARGRITALTVSDVRFPTSLDHHGSD-----AM----HPD Ornithorhynchus MATAYCILAVMHSIDPGLGSYRRGRLS-LSVAELYFPRHKSHLANSLYRGMLFISVQHTD Monodelphis --------------------MVGGRITRLSVHDVRFPTSFEGHGSD-----AM----HTD Choleopus --------------------------------------------SD-----AMVSAGHTD Sorex ---------------------------------------------------------HTD Cavia --------------------MVHGRVSRLLVHDVRFPTSLGGHGSD-----AM----HTD Loxodonta --------------------MVRGRICGLSARDVRFPTSLGGHGSD-----AM----HTD Bos --------------------MVHGRVSRLSVHDVRFPTSLGGHGSD-----AM----HTD Macaca --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD Oryctolagus --------------------MVRGRIIRLSVRDVRFPTSLGGHGSD-----AM----HTD Equus --------------------MVRGRISGLSVRDVRFPTSLGGHGSD-----AM----HTD Ailuropoda --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD Canis --------------------MVRGRICSLLVRDVRFPTSLGGHGSD-----AM----HTD Otolemur ---------------------------------------------------------HTD Callithrix --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD P.abelli --------------------MVRGRIFRLSVRDVRFPTSLGGHGSD-----AM----HTD P.pygmaeus --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD Homo --------------------MVRGRISRLSVRDVRFPTSLGGHGAD-----AM----HTD Gorilla --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD Pan --------------------MVRGRISRLSVRDVRFPTSLGGHGSD-----AM----HTD Danio --------------------MLAIKIINVSVRDVRFPTSLEQHGSD-----AM----HTD Oryzias --------------------M-SPKIVRVSVRDVRFPTSLEQHGSD-----AM----HTD Gasterosteus --------------------MSH-KITALTVRDVRFPTSVEQHGSD-----AM----HTD Tetraodon --------------------KMLPRIVKLAVTDVRFPTSLEQHGSD-----AM----HTD Fugu --------------------MLH-KIVKLTVMDVRFPTSSEQHGSD-----AM----HTD FucD PDYSAAYVVLRTDGAEDLAGYGLVFTIGRGNDVQTAAVAALAEHVVGLSVDKVIADLGAF C.intestinalis VDYSAAYVTMATDADD-VIGCGLTFSLGRGNDILVKAIEVIRGHVIGRQLSDIYSNFGKF C.savignyi VDYSAAYVTVETDSNDDIIGCGITFSLGRGNDILVKAIEAIQGLVIGRELSNIYSNFGKF Rattus -----------------------------------------LHYMVHKGLRDVVGDFTGF Xenopus PDYSAAYIVIETDAADGLKGHGLTFTLGKGTEIVVCAVRALSRHVIGKALGDIVNNFRDF Anolis PDYSAAYVVIQTDASDGLKGYGLTFTLGKGTEVVVCAINALSAHVVNRDLDEIISDFRGF Ornithorhynchus PDYSAAYVTLETDANDGLKGYGLTFTLGKGTEVVVCAVNALAHHVVNKDLAEIVSNFRGF Monodelphis PDYSAAYVIIETDAKDGLKGYGITFTLGKGTEVVVCAIHALSHHVLNKNLGEIVRNFRGF Choleopus PDYSAAYVVIETDAGDGLEGCGLTFTLGKGTEVVVCAVNALAHHLLHKDLGDIVSDFRSF Sorex PDYSAAYVTLETDAADGLRGYGFTFTLGKGTEVVVCAVNALAHHVLNKDLKDIVRDFRGF Cavia PDYSVAYVVLETDAEDGLRGCGLTFTLGKGTEVVVCAVNALAHHVLHRDLKDIVGNFRGF Loxodonta PDYSAAYVILETDAGDGLKGYGITFTLGKGTEVVICAVNALAHHVLNRDFGDIVGDFRGF Bos PDYSAAYVVLETDAEDGLKGYGITFTLGRGTEVVVCAVNALAPHVLNKDLGEIVGDFRGF Macaca PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVD-----------WSREGRGAPGDSGC- Oryctolagus PDYSAAYVVIETDAGDGLAGCGITFTLGKGTEVVVCAVNALAHHVLHKDLRDIVGDFRGF Equus PDYSAAYVVLETDAGDGLKGYGITFTLGKGTEVVVCAVNALAHHVLHKDLKDIVGDFRAF Ailuropoda PDYSAAYVVLETDVEDGLKGYGLTFTLGKGTEVVVCAVNALAHHVLNKDLRDIVGDFRGF Canis PDYSAAYVVLETDAEDGLKGYGITFTLGKGTEVVVCAVNALAHHVLNKDLSDIVGDFRGF Otolemur PDYSAAYVIIETDAEDGLKGYGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF Callithrix PDYSAAYVVIETDAEDGLKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF P.abelli PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF P.pygmaeus PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF Homo PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF Gorilla PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEIVVCAVNALAHHVLNKDLKDIVGDFRGF Pan PDYSAAYVVIETDAEDGIKGCGITFTLGKGTEVVVCAVNALAHHVLNKDLKDIVGDFRGF Danio PDYSVAYVVLETDKAE-LKGYGLTFTVGRGTEIVVCAVKALSTLVVGKTLEEITSDFRGF Oryzias PDYSAAYVVLETDG--GLRGFGLTFTLGKGTEIVVCAVQAMTGLVVGKSLEEIVRDFRGF Gasterosteus PDYSAAYVVIHTAC--GLKGFGFTFTLGKGTQIVVCAVEAVATLVVGKSLQEIVSDFRGF Tetraodon PDYSAAYVVIDTDC--GLKGFGLTFTLGKGTEIVVCAVEALARLVVGKSLQEIVSDFGGF Fugu PDYSAAYVVIETEC--GLKGFGLTFTLGKGTEIVVCAVEALAKLVVGMSWQEIVSDFRGF : FucD ARRLTNDSQLRWLGPEKGVMHMAIGAVINAAWDLAARAANKPLWRFIAELTPEQLVDTID C.intestinalis CREITQEGQLRWLGPEKGVIHMASAAIFNALWDLWGKKCGKPVWKLLAEMSPHEVVSLVD C.savignyi WREITQEGQLRWLGPEKGVVHMAAAGMFNALWDLWGKKAGKPLWKLLADMSPLEVVNLVD Rattus CRQLTHDGQLRLVRKERCVERLARAAILNAVRDLWAKQKGKPLWKLRVDMDPEMLLSCVD Xenopus YRQLTSDGQLRWIGPEKGAVQLATAAVLNAVWDLWAKKEKKPLWKLLVDMDPHQLVSCID Anolis YRQLTSDGQLRWIGPEKGAVHLATAAILNAVWDLWAKQEGKPLWKLLVDMDPKQLLSCID Ornithorhynchus YRQLTSDGQLRWIGPEKGVVHLATAAILNAVWDLWAKQEGKPLWKLLVDMDPKQLLSCID Monodelphis YRQLTSDGQLRWIGPEKGVVHLATAAILNALWDLWAKQEGKPLWKLLVDMDPKQLLSCID Choleopus YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPLWKLLVDMDPKAVLSCID Sorex YRELTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGK----LLVDMDPRTLLSCID Cavia YRQLTSDGQLRWIGPEKGAVHLATAAILNAVWDLWAKQEGKPLWKLLVDMDPRTLLSCID Loxodonta YRQLTSDGQLRWIGPEKGVVHLATAAILNALWDLWAKQEGKPLWKLLVDMDPKTLLSCID Bos YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPLWKLLVDMDPRTLVSCID Macaca --------------PKCGVGLVGQAG-------------GKACLEVTCG-HGETLVSCID Oryctolagus YRQLTSDGQLRWIGPKKGVVHLATAAVLNAVWDLWAKQEGKPLWKLLVDMDPRTLLSCID Equus YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGK---------DPRTLLSCID Ailuropoda YRQLTSDGQLRWIGPEKGVVHLATAAILNAVWDLWAKQEGKPLWKLLVDMDPRTLLSCID Canis YRQLTSDGQLRWIGPEKGVVHLATAAILNAVWDLWAKQEGKPLWKLLVDMDPRTLLSCID Otolemur YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPLWKLLVDMDPRTLVSCID Callithrix YRQLASDGQLRWIGPEKGVVHLATAAILNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCID P.abelli YRQLTSDGQPRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCID P.pygmaeus YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCID Homo YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRMLVSCID Gorilla YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCID Pan YRQLTSDGQLRWIGPEKGVVHLATAAVLNAVWDLWAKQEGKPVWKLLVDMDPRTLVSCID Danio YRLLSSDGQMRWIGPEKGVIHLATAAVLNAVWDLWARVERKPLWKLLVDMDPAKLISCID Oryzias YRLLTSDGQMRWLGPEKGVIHLATAALLNAVWDLWARMEGKPLWKLLVDMSPERLVSCID Gasterosteus YRLLTSDGQMRWLGPEKGVIQLAVAAVLNAVWDLWARAEGKPLWKLLVDMDPRQLASCID Tetraodon YRLLTSESQLRWLGPEKGVIHLASAAVLNAVWDLWARAEGKPLWKLLVDMDPKQIVSCID Fugu YRLLTSESQLRWLGPEKGVIHLASAAVLNAVWDLWARAEGKPLWKLLVDMDPKQIVSCID : . :. .. * : . :* FucD FRYLSDALTRDEALAILRDAQPQRAARTATLIEQGYPAYTTSPGWLGYSDEKLVR----- C.intestinalis FSYITDVLTKDEALKLLTRNKGTQKERELILMEKGFPAYTTSTAWLGYSDETLVK----- C.savignyi FSYITDAITKQEAMDILTRNKTSQKEREDQLLKRGFPAYTTSTAWLGYSDETLVK----- Rattus F--LIDVLTKQGAYGELCNGQLGKKEREKQMLRHGYPAYTVSCAWLGYSDSTLKL----- Xenopus FRYITDALTEEEALEILQNGKQGQRDREEHMLRSGYPAYTTSCAWLGYSDEQLKK----- Anolis FRYITDALTEEEAYTILQKGLVGKKEREEQMLKYGYPAYTTSCAWLGYPDQQLKQ----- Ornithorhynchus FRYITDALTEEEAYEILQKGLVGKKEREEQMLKNGYPAYTTSCAWLGYSDQRLKQ----- Monodelphis FRYITDALTEEEAYEILQKGSIGKKEREKQMLEHGYPAYTTSCAWLGYSDQQLKQ----- Choleopus FRYITDALTEEEAYEILQKGRVGNKEREEQMLTCGYPAYT-------------------- Sorex FRYITDVLTEEEAYEILREGEAAKKEREKQMLAQGYPAYTTSCAWLGYSDDMLKQ----- Cavia FRYITDALTEEDALEILQKGQVGKKEREEQILTHGYPAYTTSCAWLGYPDDLLKQ----- Loxodonta FRYISDALTEEEAYEILKKGRVGHREREAQLLAHGYPAYTTSCAWLGYSDDTLKQ----- Bos FRYITDVLTEEEACEILRQSQVGKKEREEQMLAHGYPAYTTSCAWLGYPDATLKQ----- Macaca FRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- Oryctolagus FRYITDVLTEEDAYDILQQAQVGKKEREEQMLTHGYPAYTTSCAWLGYSDDTLKQ----- Equus FRYITDVLTEEEAFEILQKGQVGKKEREEQMLVQGYPAYTTSCAWLGYSDDTLKQVGLXP Ailuropoda FRYITDVLTEEEAYEILQKGQVGKKEREGQMLMRGYPAYTTSCAWLGYSDDMLRQ----- Canis FRYITDVLTEEEAYEILQKGQVGKKEREGQMLMHGYPAYTTSCAWLGYSDDTLKQ----- Otolemur FRYITDVLTEEDAYEILQKGQVGKKEREGHMLAHGYPAYTTSCAWLGYSDDTLKQ----- Callithrix FRYITDVLTEEDALEILQKGQVGKKEREEQMLAQGYPAYTTSCAWLGYSDDTLKQ----- P.abelli FRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- P.pygmaeus FRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- Homo FRYITDVLTEEDALEILQKGQIGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- Gorilla FRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- Pan FRYITDVLTEEDALEILQKGQVGKKEREKQMLAQGYPAYTTSCAWLGYSDDTLKQ----- Danio FRYLTDALTEQEALDILVKGKKDQKSREEQMLKEGYPAYTTSCAWLGYTDQQLTQ----- Oryzias FRYITDVLTEEEALELLVKAQEGKRQREEEMLREGYPAYTTSCAWLGYFDQQLKQ----- Gasterosteus FRYITDALTEEEAVDMIVKAQEGKQQREDQMLKEGYPAYTTSCAWLGYPDQLLRQ----- Tetraodon FRYITDALTEEEALDILLKAREGRKQREDQMLREGYPAYTTSCAWLGYSDELLTQ----- Fugu FRYITDALTEEEALDILLKAREGRQQREDQMLREGYPAYTTSCAWLGYSDEQLTQ----- * : *.:* : * : . * :: *:**** FucD -LAKEAVADGFRTIKLKVGANVQDDIRRCRLARAAIGPDIAMAVDANQRWDVGPAIDW-M C.intestinalis -KCREALVEGWTKFKMKVGSNVDDDKRRAKLIRDEIGYNCDLMMDANQKWDVKEAIEW-M C.savignyi -KCQEALAQGWTKFKMKVGSDIDDDVRRANIIRDQIGYDRDLMMDANQKWDVNEAIEW-M Rattus -LSQTCLKFGKTHFYRKSRCSCQDDIQRCCLIRDMNGPEKTLGQDI-MIWKLDESILWLM Xenopus -LCSDALKEGWTRFKVKVGADLKDDIRRCELIRGMIGPDNIMMLDANQRWDVQEAISW-V Anolis -LCTEALKDGWTRFKVKVGADLQDDIRRCRLVREMIGPENILMLDANQRWEVEEAIEW-V Ornithorhynchus -LCQKALEDGWTRFKVKVGADLQDDMRRCRLLRELIGPENILMLDANQRWDVQEAVEW-V Monodelphis -LCSEALKEGWTRFKVKVGADLEDDIRRCRIIRDMIGPEKTLMVDANQRWDVPEAVEW-M Choleopus -LCTGALKDGWTRFKVKVGADLQDDIRRCRLIRDMIGPHNTLMLDANQRWDVPEAVEW-M Sorex -LCTKALKDGWTRFKVKVGGDIQDDIRRCRFIRNMIGPDKTLMLDANQRWDVPEAVEW-M Cavia -LCAAALKDGWTRFKVKVGADLQDDMRRCRLIRDLIGPDRTLMMDANQRWDVPEAVAW-M Loxodonta -LCSEALKEGWTRFKVKVGADLQDDIRRCRLIRDMIGPEKTLMMDANQRWDVHEAVEW-M Bos -LCSEALKDGWTRFKVKVGADLQDDIRRCRLVRNMIGPEKTLMMDANQRWDVPEAVEW-M Macaca -LCAQALKDGWTRFKVKVGADLQDDVRRCQIIRDMIGPEKTLMMDANQRWDVPEAVEW-M Oryctolagus -RCAEALKDGWTRFKVKVGADLQDDMRRCRLIRDMIGPEKTLMMDANQRWDVPEAVEW-M Equus WFCRQVLYSWWTLFKVKVGADLQDDIRRCRLIRNTIGPEKTLMMDANQRWDVPEAVEW-M Ailuropoda -LCTEALKDGWTRFKVKVGADLQDDIRRCRLIRNMIGPEKTLMMDANQRWDVPEAIEW-M Canis -LCTEALKAGWTRFKVKVGADLQDDVRRCRLIRNMIGPEKTLMMDANQRWDVPEAVKW-M Otolemur -LCTEALKDGWTRFKVKVGADVQDDMRRCRLIRDMIGPENTLMMDANQRWDVPEAVEW-M Callithrix -LCTQALKDGWTRFKVKVGADLQDDERRCQLIRDVIGPEKTLMMDANQRWDVPEAVEW-M P.abelli -LCAQALKDGWTRFKVKVGADLQDDVRRCQIIRDMIGLEKTLMMDANQRWDVPEAVEW-M P.pygmaeus -LCAQALKDGWTRFKVKVGADLQDDVRRCQIIRDMIGLEKTLMMDANQRWDVPEAVEW-M Homo -LCAQALKDGWTRFKVKVGADLQDDMRRCQIIRDMIGPEKTLMMDANQRWDVPEAVEW-M Gorilla -LCAQALKDGWTRFKVKVGADLQDDMRRCQIIRDMIGPEKTLMMDANQRWDVPEAVEW-M Pan -LCAQALKDGWTRFKVKVGTDLQDDMRRCQIIRDMIGPEKTLMMDANQRWDVPEAVEW-M Danio -LCNEALAQGWTKFKVKVGADLQDDIRRCSLIRKLIGPNNTLMIDANQRWDVNEAITW-V Oryzias -LCTDALKGGWTKFKVKVGADLDDDVRRCRLIRQMIGPDNTLMIDANQRWDVSEAISW-V Gasterosteus -LCTDALKSGWTRFKVKVGGDLEDDVRRCRLIRQMIGPENTLMIDANQRWGVAEAISW-V Tetraodon -LCADALGNGWTKFKVKVGADLEDDRRRCRLIREMIGPSNTLMMDANQRWDVAEAIRW-V Fugu -LCTDALQKGWTKFKVKVGADLEDDRRRCRLLRKIIGQSNTLMIDANQRWDVAEAIRW-V . : : * . .** .*. : * * : * * : :: * : FucD RQLAEFDIAWIEEPTSPDDVLGHAAIRQGITP--VPVSTGEHTQNRVVFKQLLQAGAVDL C.intestinalis KQLVEFRPLWIEEPTCPDDVIGHATIAKALSPHNVGVATGEQCQNRVVFKQLLQVDGLKF C.savignyi KPLVKFRPLWIEEPTSPDDVIGHATIAKALKEHKVGVATGEQCQNRVIFKQLMQTNAVSF Rattus SILAEFKPLWIEKPTSQNDIIGHATISEALAPLGIGIATGEQCHNRVMIKQLLH-KALQL Xenopus KDLAKYKPLWIEEPTSPDDILGHATISKALSPLNIGVATGEQCHNRVMFKQFLQANALQY Anolis TKLAEFKPLWIEEPTSPDDVLGHATISKALALLGIGVATGEQCHNRVVFKQLLQAQALSY Ornithorhynchus SKLAEFKPLWIEEPTSPDDILGHATISKALSPLGIGVATGEQCHNRVIFKQLLQAKALQY Monodelphis LKLAEFKPLWIEEPTSPDDILGHATISKALAPLGIGVATGEQCHNRVIFKQLLQAGALQF Choleopus LKLAEFKPLWIEEPTSPDDILGHAAIAK--------------CHNRVMFKQLLQAKALQF Sorex AKLAEFKPLWIEEPTSPDDILGHAAISK--------------CHNRVMFKQLLQAKALQF Cavia SKLAEFKPLWIEEPTSPDDILGHAAIAKALAPLGIGVATGEQCHNRVVFKQLLQANALQF Loxodonta SQLAEFKPLWIEEPTSPDDILGHAAISKALAPLGIGVATGEQCHNRVIFKQLLQANALQF Bos TKLAEFKPLWIEEPTSPDDILGHAAISKALAPLGIGVATGEQCHNRVIFKQLLQAKALKF Macaca SKLAKFKPLWIEEPTSPDDILGHAAISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQF Oryctolagus SKLAEFKPLWIEEPTSPDDILGHATISKALVPLGIGVATGEQCHNRVIFKQLLQANALQF Equus SKLAEFKPLWIEEPTSPDDILGHAAISKALVPLGIGVATGEQCHNRVIFKQLLQAKALQF Ailuropoda SKLAEFKPLWIEEPTSPDDILGHATISKALAPLGIGVATGEQCHNRVIFKQLLQAKALQF Canis SKLAEFKPLWIEEPTSPDDILGHATISKALAPLGIGVATGEQCHNRVIFKQLLQAKALQF Otolemur SKLAEFKPLWIEEPTSPDDILGHAAISK--------------CHNRVIFKQLLQANALQF Callithrix SKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGVATGEQCHNRVIFKQLLQVKALQF P.abelli SKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQF P.pygmaeus SKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQF Homo SKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQF Gorilla SKLAKFKPLWIEEPTSPDDILGHATISRALVPLGIGIATGEQCHNRVIFKQLLQAKALQF Pan SKLAKFKPLWIEEPTSPDDILGHATISKALVPLGIGIATGEQCHNRVIFKQLLQAKALQF Danio TKLAEFQPLWIEEPTCPDDILGHASISKALAPLGIGVASGEQCHNRVMFKQFLQASALQF Oryzias SNLAEVKPLWIEEPTSPDDILGHAAISKALAPLGIGVATGEQCHNRVMFKQFLQAGALQF Gasterosteus SRLAEFKPLWIEEPTSPDDILGHAAISKALAPLGIGVATGEQCHSRVMFKQFLQASALQF Tetraodon SSLADFKPLWIEEPTCPDDILGHAAISKALAPLGIGVASGEQCHNRVMFKQFLQASAL-F Fugu SSLAEFNPLWIEEPTCPDDILGHAAISKALAPLGIGVASGEQCQNRVMFKQFLQASALQF *.. ***:**. :*::***:* :.**::**::: .: FucD IQIDAARVGGVNENLAILLLAAKFGVRVFPHAGGVGLCELVQHLAMADFVAITGKMEDRA C.intestinalis LQIDSCRVGSINENIAILLMAAKFNVPVCPHAGGVGLCELVQHIIMFDYLCVSATNEQRM C.savignyi VQIDSCRVGSINENIAILLMAAKFNLPVCPHAGGVGLCELVQHIIMFDYLCVSATTDGRV Rattus LQIDSCRLGSVKENLSVSLMPKKFGIHLPPCWWSWTLNWLVQHLIIFDCQSLPAFKTGRM Xenopus LQIDSCRLGSVNENLSVLLMSKKFNVPVCPHAGGVGLCELVQHLILFDYISVSGSLDNRM Anolis VQIDSCRLGSVNENLSVLLMAKKFQIPVCPHAGGVGLCELVQHLIIFDYISISGSLENRM Ornithorhynchus LQIDSCRLGSVNENLSVLLMAKKFQIPVCPHAGGVGLCELVQHLIIFDFISVSGSLENRM Monodelphis LQIDSCRLGSVNENLSVLLMAKKFQIPVCPHAGGVGLCELVQHLIIFDYISISGSLENRM Choleopus LQIDSCRLGSVNENLSVLLMAKKFGIPVCPHAGGVGLCELVQHLILFDYISVSACLQNRM Sorex LQIDSCRLGSVNENLSVLLMAKKFQIPVCPHAGGVGLCELVQHLIIFDFISISASLENRM Cavia LQIDSCRLGSVNENLSVILMAKKFGIPVCPHAGGVGLCELVQHLIIFDYISVSTSLQNRM Loxodonta LQIDSCRLGSINENVSVLLMAQKFGIPVCPHAGGVGLCELVQHLIIFDYIAVSASLENRM Bos LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDFISVSASLQDRM Macaca LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLKNRM Oryctolagus LQIDSCRLGSVNENLSVILMAKKFGIPVCPHAGGVGLCELVQHLIIFDYIAVSASLKNRM Equus LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDFISVSASLTNRM Ailuropoda LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDFISVSASLRNRM Canis LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDFISISASLQNRM Otolemur LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRM Callithrix LQIDSCRLGSINENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYVSVSASLKNRM P.abelli LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRM P.pygmaeus LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRM Homo LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRV Gorilla LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRV Pan LQIDSCRLGSVNENLSVLLMAKKFEIPVCPHAGGVGLCELVQHLIIFDYISVSASLENRV Danio VQIDSCRVGSVNENLATILMAAKFNVPVCPHAGGVGLCELVQHLILFDYISVSASLSNRM Oryzias VQIDSCRLGSVNENLAVLLMAHKFRVPVCPHAGGVGLCELVQHLILFDYICVSASLSNRM Gasterosteus VQIDGCRVGSVNENLAVLLMAHKFQVPVCPHAGGVGLCELVQHLILFDYISVSGSLSNRM Tetraodon VQIDSCRLGSVNENLAVLLMAHKFQVPVCPHAGGVGLCELVQHLILFDYICVSGSLANRM Fugu VQIDSCRLGSINENLAVLLMAHKFQVPVCPHAGGVGLCELVQHLSLFDYICVSGSLTNRM :***..*:*.::**:: *:. ** : : * . * ****: : * .:. * FucD IEFVDHLHQHFLDPVRIQHGRYLAPEVPGFSAEMHPASIAEFSYPDGRFWVE--DLAASK C.intestinalis CEYVDHLHEHFIEPVVIQNTCYMPPKKPGYSSEMKKDSVENYKFPDGKIWKD--LIEGGK C.savignyi CEYVDHLHEHFVEPVRIKDASYMSPQKPGYSSEMKAESLDNYEFPNGTIWSN--LIKEGK Rattus CEYVDHLHEHFKYPMVIKHASYLPPKDAGFSTKMK------------------------- Xenopus CEYVDHLHEHFMYPVIISRAAYMPPKDPGYSTEMKDESVLQYQFPDGEIWQK-------- Anolis CEYVDHLHEHFKYPVVIKNASYMPPQAPGYSSEMKEDSVRKYQFPQGEIWQK--LLSDPQ Ornithorhynchus CEFVDHLHEHFKYPVVIKKASYMPPQDPGYSSEMKEDSVKQHEFPEGEVWQN--LMAAQK Monodelphis CEYVDHLHEHFKYPVVIKKASYMPPKDAGYSTEMKEESVKEHQFPEGKIWQK--LMAAQK Choleopus CEYVDHLHEHFKYPVTIKKASYMPPKDAGYSTEMKEESVNEYQYPDGEVWKK--LLAAQE Sorex CEYVDHLHEHFKYPVRIQKAAYMPPKDPGYSTEMKEESIKQHQYPDGDVWKK--LLAAQG Cavia CEYVDHLHEHFKYPVYIKQASYMPPQDAGYSTEMKEDSVKKHQYPDGEVWRK--LLAAQE Loxodonta CEYVDHLHEHFKYPVIIKKASYMPPEDPGYSTEMKEESVKKHQFPDGEVWTK--LLAGQE Bos CEYVDHLHEHFKYPVLIREAAYMPPKDAGYSTEMKEDSVKRHRYPDGEVWKK--LLSAQG Macaca CEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLAAQE Oryctolagus CEYVDHLHEHFKYPVTIKQASYMPPKAAGYSTEMKEESVKKHQYPEGEVWKR--LHAAHE Equus CEYVDHLHEHFKYPVVIEKASYMPPKDAGYSTEMKEDSVKKHQYPDGEVWKK--LLAARG Ailuropoda CEYVNHLHEHFRYPVIIKKASYMPPKDAGYSTEMKEESIKKHQYPDGEVWKK--LLAAQE Canis CEYVDHLHEHFRYPVIIKKASYMPPKDAGYSTEMKEESVKKHQYPDGEVWKK--LLAAQE Otolemur CEYVDHLHEHFKYPVKIRQASYMPPMDAGYSTEMKEESVKKHQYPDGEVWKK--LLATQE Callithrix CEYVDHLHEHFKYPVVIQRASYMPPKDAGYSTEMKEESVKKHQYPDGEVWKK--LLAAQE P.abelli CEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLAAQE P.pygmaeus CEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLAAQE Homo CEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLPAQE Gorilla CEYVDHLHEHFKYPVMIQQASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLPAQE Pan CEYVDHLHEHFKYPVMIQRASYMPPKDPGYSTEMKEESVKKHQYPDGEVWKK--LLPAQE Danio CEFVDHLHEHFKSPTVIRNAKYIPPKDPGFSCEMLEESVKKHQYPEGEVWRA--IEKQQK Oryzias CEYVDHLHEHFVCPVVIHNARYMPPKIPGYSCEMLESSVKKHQYPDGDAWK---LYPKK- Gasterosteus CEYVDHLHEHFTSPVVIRDAHYMPPKDPGFSCEMLESSVQRHQYPEGEVWKL--NISK-- Tetraodon CEYVDHLHEHFASPVVIRNGHYIAPEDIGYSCEMLESSVQSHRYPEGDVWKA--NTSKPE Fugu CEYVDHLHEHFASPVVIRNGHYMPPKDLGYSCEMLASSVQAHRYPEGDVWKKTFLVVSSG *:*:***:** * * *:.* *:* :* FucD AKA--- C.intestinalis FVQ--- C.savignyi FKM--- Rattus ------ Xenopus ------ Anolis T----- Ornithorhynchus L----- Monodelphis N----- Choleopus N----- Sorex N----- Cavia N----- Loxodonta N----- Bos N----- Macaca N----- Oryctolagus N----- Equus N----- Ailuropoda N----- Canis N----- Otolemur N----- Callithrix N----- P.abelli N----- P.pygmaeus N----- Homo N----- Gorilla N----- Pan N----- Danio ------ Oryzias ------ Gasterosteus ------ Tetraodon VKMDTF Fugu N-----