nature nanotechnology | ADVANCE ONLINE PUBLICATION | www.nature.com/naturenanotechnology 1
review article
Published online: 29 march 2009 | doi: 10.1038/nnano.2009.58
The development of various methods for producing graphene — a single layer of carbon atoms bonded together in a hexagonal lattice — has stimulated a vast amount of research in recent
years1. The remarkable properties of graphene reported so far
include high values of its Young’s modulus (~1,100 GPa)2, fracture
strength (125 GPa)2, thermal conductivity (~5,000 W m−1K−1)3,
mobility of charge carriers (200,000 cm2 V−1 s−1)4 and specific sur-
face area (calculated value, 2,630 m2 g−1)5, plus fascinating trans-
port phenomena such as the quantum Hall effect6. Graphene and
chemically modified graphene (CMG) are promising candidates
as components in applications such as energy-storage materi-
als5, ‘paper-like’ mater ials7,8, polymer composites9,10, liquid crystal
devices11 and mechanical resonators12.
Graphene has been made by four different methods. The first
was chemical vapour deposition (CVD) and epitaxial growth, such
as the decomposition of ethylene on nickel surfaces13. These early
efforts (which started in 1970) were followed by a large body of
work by the surface-science community on ‘monolayer graphite’14.
The second was the micromechanical exfoliation of graphite15.
This approach, which is also known as the ‘Scotch tape’ or peel-off
method, followed on from earlier work on micromechanical exfo-
liation from patterned graphite16. The third method was epitaxial
growth on electrically insulating surfaces such as SiC (ref. 17) and
the fourth was the creation of colloidal suspensions.
Micromechanical exfoliation has yielded small samples of
graphene that are useful for fundamental study. Although large-
area graphene films (up to ~1 cm2) of single- to few-layer graphene
have been generated by CVD growth on metal substrates18–20, and
graphene-type carbon materials have been produced by substrate-
free CVD21, radio-frequency plasma-enhanced CVD22, aerosol
pyrolysis23 and solvothermal synthesis24, the uniform growth of
single-layer graphene is still a challenge. In this review, we dis-
cuss the production of graphene and CMG from colloidal suspen-
sions made from graphite, derivatives of graphite (such as graphite
oxide) and graphite intercalation compounds. This approach is
both scalable, affording the possibility of high-volume produc-
tion, and versatile in terms of being well-suited to chemical func-
tionalization. These advantages mean that the colloidal suspension
method for producing graphene and CMG could be used for a
wide range of applications.
graphenes from graphite oxide
Since it was first prepared in the nineteenth century25,26, graphite
oxide has been mainly produced by the Brodie25, Staudenmaier27
and Hummers28 methods. All three methods involve oxidation of
chemical methods for the production of graphenes
sungjin Park1 and rodney s. ruoff1*
Interest in graphene centres on its excellent mechanical, electrical, thermal and optical properties, its very high specific surface
area, and our ability to influence these properties through chemical functionalization. There are a number of methods for gen-
erating graphene and chemically modified graphene from graphite and derivatives of graphite, each with different advantages
and disadvantages. Here we review the use of colloidal suspensions to produce new materials composed of graphene and
chemically modified graphene. This approach is both versatile and scalable, and is adaptable to a wide variety of applications.
graphite in the presence of strong acids and oxidants. The level of
the oxidation can be varied on the basis of the method, the reaction
conditions and the precursor graphite used. Although extensive
research has been done to reveal the chemical structure of graphite
oxide, several models are still being debated in the literature.
Solid-state 13C NMR spectroscopy of graphite oxide and recently
of 13C-labelled graphite oxide favours the model shown in Fig. 1a; the
sp2-bonded carbon network of graphite is strongly disrupted and a sig-
nificant fraction of this carbon network is bonded to hydroxyl groups
or participates in epoxide groups29–32. Minor components of carboxylic
or carbonyl groups are thought to populate the edges of the layers in
graphite oxide. This indicates that further work with solid-state NMR
on 13C-labelled graphite oxide is necessary, along with (for example)
titration with fluorescent tags of carboxylic and other groups to iden-
tify their spatial distribution on individual graphene oxide platelets
derived from graphite oxide as discussed further below.
Graphite oxide thus consists of a layered structure of ‘graphene
oxide’ sheets that are strongly hydrophilic such that intercalation
of water molecules between the layers readily occurs33. The inter-
layer distance between the graphene oxide sheets increases revers-
ibly from 6 to 12 Å with increasing relative humidity33. Notably,
graphite oxide can be completely exfoliated to produce aqueous
colloidal suspensions of graphene oxide sheets by simple sonication
(Fig. 1b)34 and by stirring the water/graphite oxide mixture for a
long enough time35. The measurement of the surface charge (zeta
potential) of graphene oxide sheets36 shows that they have negative
charges when dispersed in water. This suggests that electrostatic
repulsion between negatively charged graphene oxide sheets could
generate a stable aqueous suspension of them. A considerable body
of work37,38 on such aqueous colloidal suspensions was carried out
in the 1950s and 1960s. Such graphene oxide sheets probably have
a similar chemical structure to the layers in graphite oxide and are
a promising starting material in the generation of colloidal suspen-
sions of other CMGs through chemical tuning. Filtration of CMG
suspensions has produced free standing paper-like materials7,36,39–41
that have a layered structure (Fig. 1c, d). Significant advances have
also been made in using homogeneous suspensions of CMG sheets
to produce thin films, which can be relevant to transparent and elec-
trically conductive thin-film applications, among others36,39–44
unreduced graphene oxide sheets
Several authors have stated that homogeneous colloidal suspen-
sions of graphene oxide in aqueous and various organic solvents
can be achieved by simple sonication of graphite oxide8,34,45–47.
The hydrophilic graphene oxide can be easily dispersed in water
1Department of Mechanical Engineering and the Texas Materials Institute, University of Texas at Austin, One University Station C2200, Austin, Texas
78712-0292, USA. *e-mail: r.ruoff@mail.utexas.edu
© 2009 Macmillan Publishers Limited. All rights reserved.
2 nature nanotechnology | ADVANCE ONLINE PUBLICATION | www.nature.com/naturenanotechnology
review article NaTure NaNoTecHNology doi: 10.1038/nnano.2009.58
(at concentrations up to 3 mg ml−1)8,34,45,47, affording brown/dark-
brown suspensions. (See Table 1 for a list of solvents used, the
concentrations of colloidal suspensions, the lateral dimensions
and heights of graphene oxide sheets, and the type of precur-
sor material used, be it graphite oxide or graphite or expandable
graphite.) The exfoliation to achieve graphene oxide sheets has
been most typically confirmed by thickness measurements of the
single graphene sheet (~1-nm height on substrates such as mica)
using atomic force microscopy (AFM).
Graphite oxide can be dispersed directly in several polar solvents
such as ethylene glycol, DMF, NMP and THF at about 0.5 mg ml−1
(ref. 46). It has also been shown that the chemical modification of
graphene oxide sheets by organic molecules yields homogeneous
suspensions in organic solvents45; reaction of graphite oxide with iso-
cyanate groups produced isocyanate-modified graphene oxide sheets
that are well dispersed in polar aprotic solvents. It was proposed that
carbamate and amide functional groups are generated by the reac-
tion of isocyanate with hydroxyl and carboxyl groups (Fig. 2a)45.
The amide-coupling reaction48 between the carboxyl acid
groups of graphene oxides and octadecylamine (after SOCl2
activation of the COOH groups) was used in ref. 49 to mod-
ify graphene oxides by long alkyl chains with 20 wt% yield.
Interestingly, chemical modification of an alternative starting
material, graphite fluoride, with alkyl lithium reagents produced
alkyl-chain-modified graphene sheets that could be dispersed in
organic solvents after sonication50.
reduced graphene oxides
Although the chemical modification of graphene/graphite oxide
or graphite fluoride can generate homogeneous colloidal suspen-
sions, the resulting CMGs are electrically insulating owing to
disruption of the ‘graphitic’ networks. On the other hand, the
reduction of the graphene oxide by chemical methods (using
reductants such as hydrazine47,51,52, dimethylhydrazine9, hydro-
quinone53 and NaBH4 (refs 42 and 54), thermal methods55,56 and
ultraviolet-assisted methods57 has produced electrically conduct-
ing CMGs. (See Table 2 for a list of electrical properties of graph-
ene-based materials generated using their suspensions.)
The reduction of aqueous graphene oxide suspension by hydra-
zine at the pH of the suspension when used as made results in
0.0 0.5 1.8 1.5 2.0
Distance (μm)
4
3
2
1
0
H
ei
gh
t (
nm
)
0.0 0.5 1.8 1.5 2.0
Distance (μm)
4
3
2
1
0
H
ei
gh
t (
nm
)
0.0 0.5 1.8 1.5 2.0
Distance (μm)
4
3
2
1
0
H
ei
gh
t (
nm
)
2+2+ 2+2+22 2+2+ 22+ 2+ 2+ 2+ 2+ 2+22222+2+22 2+2+2+ 2+2+ 2+ 2+ 2 2 2+ 2+ 2 2222+ 2+2 2+ 2 2
a
b
c d
250 nm
Figure 1 | graphite oxide and graphene oxide. a, Chemical structure of graphite oxide30. For clarity, minor functional groups, carboxylic groups and
carbonyl groups have been omitted at the edges. Reproduced with permission from ref. 30. © 1998 Elsevier. b, An AFM image of exfoliated graphene
oxide sheets47; the sheets are ~1 nm thick. The horizontal lines indicate the sections corresponding (in order from top to bottom) to the traces shown on
the right. Reproduced with permission from ref. 47. © 2007 Elsevier. c, Photograph of folded graphene oxide paper7 (© 2007 NPG). d, A scanning electron
microscope image of the cross-section of the graphene oxide paper, showing layered structure7 (© 2007 NPG).
© 2009 Macmillan Publishers Limited. All rights reserved.
nature nanotechnology | ADVANCE ONLINE PUBLICATION | www.nature.com/naturenanotechnology 3
review articleNaTure NaNoTecHNology doi: 10.1038/nnano.2009.58
agglomerated graphene-based nanosheets, and, when dried, a
black powder (Fig. 2b)47 that is electrically conductive (powder
conductivity, ~2 × 102 S m−1). Elemental analysis (atomic C/O
ratio, ~10) of the reduced graphene oxides measured by com-
bustion revealed the existence of a significant amount of oxygen,
indicating that reduced graphene oxide is not the same as pris-
tine graphene. Theoretical calculations of the reduction of graph-
ene oxide (the model used for graphene oxide had the graphene
decorated with hydroxyl and epoxide groups) suggest that reduc-
tion below 6.25% of the area of the graphene oxide (C/O = 16 in
atomic ratio) may be difficult in terms of removing the remaining
hydroxyl groups58.
Homogeneous colloidal suspensions of electrically conducting
CMGs have been produced by chemical reduction with dimethyl-
hydrazine or hydrazine in the presence of either polymer or
surfactant9,34. The reduction of an aqueous suspension contain-
ing a mixture of graphene oxide sheets and poly(sodium 4-sty-
renesulphonate) afforded an aqueous black suspension of reduced
graphene oxide sheets coated in the polymer34. The reduction of
isocyanate-modified graphene oxide in the presence of polystyrene
generated a suspension of reduced graphene oxide sheets in DMF
that could then be ‘crashed out’ with methanol to yield a compos-
ite with well-dispersed and electrically conductive CMG sheets9.
Reduction of sodium dodecylbenzenesulfonate (SDBS)-wrapped
graphene oxide with hydrazine and then its chemical modifica-
tion (Fig. 2c) with aryl diazonium salt produced SDBS-wrapped
CMG that was dispersible in DMF, N,N′-dimethylacetamide, and
NMP at concentrations up to 1 mg ml−1 (ref. 51).
Colloidal suspensions of modified graphenes decorated with
small organic molecules or nanoparticles have also been reported.
In ref. 39, the reduced graphene oxide sheets were functionalized
using pyrenebutyric acid (a well-known organic molecule48 with
a strong adsorption affinity for the graphitic plane via π stack-
ing). The aqueous graphene oxide suspension was reduced using
hydrazine in the presence of pyrenebutyric acid, yielding a black
aqueous colloidal suspension (0.1 mg ml−1) of CMG adsorbed by
pyrenebutyric acid. Its paper-like material, prepared by filtration,
showed moderate electrical conductivity (2 × 102 S m−1).
The suspension (<0.48 mg ml−1) of gold-nanoparticle-modified
graphene sheets in THF was generated by the reaction of NaBH4
and octadecylamine-modified graphene oxide49 and then the addi-
tion of AuCl4
− to the suspension54. The gold nanoparticles (diam-
eter, ~5–11 nm) were anchored to the modified graphene sheets.
Graphene modified with titanium dioxide nanoparticles has also
been studied57; ultraviolet irradiation of this TiO2/graphene oxide
hybrid in ethanol was used to reduce the graphene oxide sheets
(Fig. 2d), producing a black suspension of TiO2-attached CMG
sheets in ethanol. The TiO2 was suggested to act as a photocata-
lyst, transferring photoelectrons from the TiO2 to the graphene
oxide sheets57.
A few methods for creating colloidal suspensions of graphene
sheets without the help of stabilizers or surfactants have been
Table 1 | comparison of a set of chemical approaches to produce colloidal suspensions of cMg sheets
ref. starting materials dispersible solvents concentration (mg ml−1) lateral size thickness (nm)
34 GO/MH Water 1 — —
36 GO/MH Water 0.5 Several hundred nm ~1
39 GO/MH Water 0.1 — ~1.7
40 GO/MH Water 7 Several hundred nm ~1
42 GO/H Water/methanol,
acetone, acetonitrile
mixed solvents
3–4 Several hundred nm ~1.2
45 GO/MH DMF, NMP, DMSO, HMPA 1 ~560 nm ~1
46 GO/H Water, acetone, ethanol,
1-propanol, ethylene glycol,
DMSO, DMF, NMP, pyridine,
THF
0.5 100–1,000 nm 1.0–1.4
49 GO/O DMF, THF, CCl4, DCE 0.5 — 0.5–2.5
50 Graphite fluoride DCB, MC, THF 0.002–0.54 1,600 nm ~0.95
51 GO/S DMF, DMAc, NMP 1 Several hundred nm 1.8–2.2
52 GO/MH Hydrazine 1.5 Up to 20 μm × 40 μm ~0.6
54 GO/S THF <0.48 — 1–2
55, 56, 10 GO/S NMP, DMF, DCB, THF,
nitromethane
0.1 100–2,500 nm 1.1–3.5 (ave. 1.75)
57 GO/H Ethanol 1 Several hundred nm ~2
59 Graphite powder NMP, DMAc, GBL, DMEU 0.01 Several μm 1–5
60 GIC NMP 0.15 Several hundred nm ~0.35
61 EG DCE 0.0005 Nanoribbon (width
<10 nm)
1–1.8
62 EG DMF — ~250 nm ~1
63 EG Water, DMF, DMSO 0.015–0.020 Several hundred nm to a
few μm
2–3 (2–3 layers of
graphene)
64 Graphite rod DMF, DMSO, NMP 1 500–700 nm ~1.1
GO, graphite oxide; MH, modified Hummers method; H, Hummers method; O, their own method; S, Staudenmaier method; EG, expandable graphite; GIC, graphite intercalation compound; DMF,
dimethylformamide; DMAc, N,N′-dimethylacetamide; DMSO, dimethylsulphoxide; NMP, N-methylpyrrolidone; THF, tetrahydrofuran; MC, dichloromethane; DCE, 1,2-dichloroethane; DCB,
1,2-dichlorobenzene; HMPA, hexamethylphosphoramide; GBL, γ-butyrolactone; DMEU, 1,3-dimethyl-2-imidazolidinone.
© 2009 Macmillan Publishers Limited. All rights reserved.
4 nature nanotechnology | ADVANCE ONLINE PUBLICATION | www.nature.com/naturenanotechnology
review article NaTure NaNoTecHNology doi: 10.1038/nnano.2009.58
reported. An aqueous suspension (0.5 mg ml−1) of reduced graph-
ene oxide sheets under basic conditions (pH 10) was described in
ref. 36. The graphene oxide was reduced by hydrazine, and excess
hydrazine was removed by dialysis. It was suggested that shifting
to pH 10 converts neutral carboxylic groups to negatively charged
carboxylate groups, so that when the interior of the graphene
oxide sheets are reduced by hydrazine, the negatively charged
particles do not agglomerate36; see Fig. 2e. Paper-like materials
(1) (2) (3)
2+ 2+22 2 222+ 2+2 2+2+2
2 222 2 222 2 22 +12+1
2+ &2�51&2 51&25 +15 21+5 52 +1 5 2 1+ 52 +1 5
H
H
RR
R
RBF4N2
H
O O
OH
OHO
OH
COOH COOH
H
O
N2H4 H2O pH 10
80 °C, 24 h
1a, b R = CI
2a, b R = NO2
3a, b R = OCH3
4a, b R = Br
1a–4a
1b–4b
RT, 1 h
SDBS-wrapped GO
a
b
d
e
c
e
h
h–
TiO2
250 nm
– +
Figure 2 | cMg oxide sheets. a, Proposed reaction of graphene oxide sheets with isocyanates forming carbamate (left oval) and amide (right oval)
functionalities45. b, A scanning electron microscope image of aggregated graphene oxide sheets chemically reduced with hydrazine monohydrate47. Parts
a and b reproduced with permission from ref. 47. © 2007 Elsevier. c, Starting with SDBS-wrapped graphene oxide, reduction and functionalization of
intermediate SDBS-wrapped CMG with diazonium salts51. RT, room temperature. Reproduced with permission from ref. 51. © 2008 ACS. d, TiO2–graphene
hybrid and its proposed response under UV excitation57. Reproduced with permission from ref. 57. © 2008 ACS. e, Chemical route to produce aqueous
suspension of reduced graphene oxide36. (1) Oxidation of graphite to synthesize graphite oxide. (2) Exfoliation of graphene oxide in water by sonication
of graphite oxide. (3) Controlled reduction of graphene oxide sheets by hydrazine yielding a colloidal suspension of conductive CMG sheets, which are
stabilized by electrostatic repulsion (© 2008 NPG).
© 2009 Macmillan Publishers Limited. All rights reserved.
nature nanotechnology | ADVANCE ONLINE PUBLICATION | www.nature.com/naturenanotechnology 5
review articleNaTure NaNoTecHNology doi: 10.1038/nnano.2009.58
made by filtration and then dried in air showed good electrical
conductivity (~7,200 S m−1)36.
In other work, an aqueous suspension (7 mg ml−1) of partially
reduced graphene oxides was produced, under basic conditions, by
hydrazine reduction of KOH-modified graphene oxides40. It was
suggested that the K+ ions and the carboxylate anions at the edges
of the CMG sheets formed ion pairs. The electrical conductivity of
air-dried ‘paper’ made from this material was ~690 S m−1.
In a third approach42, a graphene-based suspension was pro-
duced in three reaction steps: (1) ‘pre-reduction’ of graphene oxide
by NaBH4; (2) sulphonation by aryl diazonium salt of sulphanilic
acid; and (3) ‘post-reduction’ of aqueous sulphonated graphene
(2 mg ml−1, pH 3–10) with hydrazine. The sulphonated graphene
sheets of step 2 could be dispersed in water (2 mg ml−1, pH 3–10),
and after the post-reduction step the CMG sheets could be dis-
persed in mixed solvents of water with certain organic solvents. It
was suggested that covalent functionalization in the CMG sheets
by sulphonyl groups was occurring. The electrical conductivity of
the thin evaporated film on a glass slide after drying at 120 °C was
reported to be 1,250 S m−1 (ref. 42).
A suspension of reduced graphene oxide sheets (some with lat-
eral dimensions of up to ~20 mm × 40 mm) in anhydrous hydra-
zine was produced by stirring graphene oxide paper in anhydrous
hydrazine (10 ml for 15 mg of graphite oxide) for one week in a
nitrogen-filled dry box52. The resulting CMG on SiO2 was reported
to be ~0.6 nm in height, measured by AFM. The anhydrous
hydrazine thus acts both as a reduction agent of graphene oxide
sheets and as a dispersing solvent in this approach. The individual
CMG sheets were tested as a field-effect transistor and showed
p-type behaviour52.
Thermal treatment of graphite oxide is another route that
has been used to obtain redu
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