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第二组:磁振造影对比剂研究群第二组:磁振造影对比剂研究群 第二組:磁振造影對比劑研究群 (王雲銘教授) Name: Contrast agent for Magnetic Resonance Imaging Goal: Gadolinium(Gd(III)) based contrast agents for magnetic resonance imaging(MRI) enhance tissue contrast by increasing the longitudinal relaxation rate of water pro...

第二组:磁振造影对比剂研究群
第二组:磁振造影对比剂研究群 第二組:磁振造影對比劑研究群 (王雲銘教授) Name: Contrast agent for Magnetic Resonance Imaging Goal: Gadolinium(Gd(III)) based contrast agents for magnetic resonance imaging(MRI) enhance tissue contrast by increasing the longitudinal relaxation rate of water protons(r). To date, all commercially approved Gd(III) chelates are extracellular 1 agents with nonspecific biodistribution. A new generation of contrast agents, currently under development at this research team, targets macromolecules associated with specific tissues or disease states thereby localizing the agent to the site of interest. Efforts are also underway to develop MRI contrast agents, which are sensitive probes for cations, pH, or biological activity. In this effort toward cellular and molecular imaging, the research aims not only at increasing the relaxivity of the magnetic centers, leading to the development of superparamagnetic crystals, but also at identifying the proper vectors, a strategy which may take advantage of the techniques of molecular biology. Specific Aim: The primary objective of current research in MRI contrast agents is to widen the scope of this imaging modality from one that provides solely anatomical information to one that affords physiological and biochemical information as well. The main barrier to this endeavor is the low sensitivity when it coupled with the low flux of most biochemical processes. This problem can be addressed by developing contrast agents that possess higher spin-lattice relaxivity (r). The polymeric MRI contrast 1 agents possess several gadolinium ions; it will not only increase the relaxivity (r) but 1 also possess high thermodynamic stability. The specific aim of research team will develop synthetic methodology for polymeric and bioactivated metal chelates and to explore further the fundamental solution dynamic properties of these new bioactivated compounds to aid in MRI contrast agent design and applications.
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