浙江东盈药业有限公司头孢原料药环评

浙江东盈药业有限公司头孢原料药环评 本 报告 软件系统测试报告下载sgs报告如何下载关于路面塌陷情况报告535n,sgs报告怎么下载竣工报告下载 简本仅供公众 调查公示期间查阅用 浙江东盈药业有限公司 年产50吨头孢类无菌原料药GMP项目 (简 本) HANGZHOU ACADEMY OF ENVIRONMENTAL SCIENCE 国环评证乙字第2004号 二??六年九月 rAt present, we have formed a "three-three" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses large, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilities 目 录 1 项目概况..................................................................................................................................1 1.1 公司概况和项目由来 ............................................................................................................1 1.2 项目名称和性质 ...................................................................................................................1 1.3 立项情况 .............................................................................................................................1 1.4 建设规模 .............................................................................................................................1 1.5 项目建设地点 ......................................................................................................................1 2 工程内容及污染因素 分析 定性数据统计分析pdf销售业绩分析模板建筑结构震害分析销售进度分析表京东商城竞争战略分析 .........................................................................................................2 2.1 项目工程内容 ......................................................................................................................2 2.2 项目污染源强汇总 ...............................................................................................................4 3 选址周边环境及保护目标 .........................................................................................................6 3.1 周边环境概况 ......................................................................................................................6 3.2周边环境质量现状 ................................................................................................................6 3.3 保护目标 .............................................................................................................................7 4 环境影响分析...........................................................................................................................8 4.1 环境空气影响分析 ...............................................................................................................8 4.2 水环境影响分析 ...................................................................................................................8 4.3 声环境影响分析 ...................................................................................................................8 4.4 固体废物影响分析 ...............................................................................................................9 5 对策措施................................................................................................................................ 10 6 总量控制及环境效益 .............................................................................................................. 11 6.1 总量控制 ........................................................................................................................... 11 6.2 环境效益 ........................................................................................................................... 11 7 环境可行性及评价结论 .......................................................................................................... 12 7.1 是否符合国家产业政策 ...................................................................................................... 12 7.2 是否符合城市环境功能区划和城市总体发展规划，做到合理布局 ....................................... 12 7.3 技术与装备政策是否符合清洁生产 ..................................................................................... 12 7.4 是否做到污染物达标排放 ................................................................................................... 12 7.5 是否满足国家和地方规定的污染物总量控制指标 ................................................................ 13 7.6 是否能维持地区环境质量，符合功能区要求。 ................................................................... 13 8 环评总结论 ............................................................................................................................ 14 附图 aminatnation and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrative exiness environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the administrative examior busze government service. Low efficiency of government services, departments do not coordinate the views of businesses large, pomely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. Second is to optimin a tithe starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undertake iompany" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ... Wood Park as oad c1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promote the "r to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park to determineture, rther improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other infrastrucon development needs in the next decade, based on the original, and then extended the 6 square kilometers. Of the Park, to futhree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus -rAt present, we have formed a "three, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitiesion and approval matters, strengthen the existing supervision in matters of administrative power, has made it clear to cancel1 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 1 项目概况 1.1 公司概况和项目由来 浙江东盈药业有限公司是盈天医药集团有限公司与上虞仁和精细化工有限公司合资成立的生产型企业，主要从事头孢类无菌原料药(GMP)的研发、生产和经营。盈天医药集团有限公司具有较强的研发、生产和药品市场开拓能力，随着集团公司的迅速发展，在战略上极需在国内建立一个GMP原料药生产基地。上虞仁和精细化工有限公司一直致力于开发合成具有先进技术的医药中间体，产品大部分出口，该公司的头孢类无菌原料药合成技术在国内处于领先地位，特别是头孢夫辛钠的合成技术，取得了工艺技术的突破，大大提高了产品质量，而成本却大幅度降低。盈天公司和仁和公司的合资，将会使双方的优势得到更好发挥，从而做大做强企业。 浙江东盈药业有限公司拟投资1500万元建设年产50吨头孢类无菌原料药GMP生产线，其工艺是完成最终产品的前一步化学合成(酸碱成盐，即结晶)，再通过物理方法进行过滤、洗涤、烘干、包装得到无菌原料药。项目选址于仁和公司现有厂区内。 1.2 项目名称和性质 (1)项目名称:浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目 (2)项目性质:新建 1.3 立项情况 上虞市发展 计划 项目进度计划表范例计划下载计划下载计划下载课程教学计划下载 局:虞计外资[2005]79号。 1.4 建设规模 该项目总投资人民币1500万元。建成年产50吨的头孢类无菌原料药GMP生产线，生产产品为头孢呋辛钠，项目实施后，可实现年销售额1.5亿元，年上缴税收近2500万元。 1.5 项目建设地点 项目租用浙江省杭州湾精细化工园区上虞仁和精细化工有限公司厂区内的西侧地块，该地块现为空地。 -1- 2 工程内容及污染因素分析 2.1 项目工程内容 项目生产工艺及产污流程见附图1。 (1)钠盐溶液的配制、脱色及过滤: ?往钠盐溶解罐中加入注射用水50kg和95,乙醇400kg;再加入固体氢氧化钠10.0kg，常温搅拌至完全溶解。 ?加入活性炭1.5kg，搅拌脱色30min。 ?打开钠溶解罐至钠盐计量罐的相关阀门，用氮气将钠盐溶液通过钠盐过滤系统压制钠盐计量罐中待用。 (2)头孢呋辛酸的溶解、脱色及过滤: ?开启酸溶罐夹套水循环使温度为20?,25?。 ?往酸溶罐中加入注射用水30kg，搅拌30min，再加入丙酮600kg，搅拌使混合均匀。 ?加入头孢呋辛酸100kg，搅拌至头孢呋辛酸完全溶解。 ?加入活性炭3.5kg，搅拌脱色20min。 ?打开酸溶罐至结晶罐之间相应阀门，用氮气将酸溶罐中的头孢呋辛酸溶液压入结晶罐中，完毕后打开阀门，放空反应釜，放空时间约为10min。 (3)成盐结晶: ?开启结晶罐夹套水循环和搅拌，使头孢呋辛酸液温度保持在28?,30?。 ?钠盐溶液匀速滴加至结晶罐中，滴加时间为40,45min，滴加完毕搅拌10min。 ?在20分钟内，向结晶罐泵入丙酮200kg，保温搅拌20min，使头孢呋辛钠充分析晶。 ?将结晶液压至多能罐中，同时母液压至母液储罐，同时打开氮气阀门放空反应釜，放空时间约为10min。储罐中母液 (4)洗涤过程: ?通过溶媒过滤系统将无水乙醇200kg泵至多能罐中进行第一次洗涤:开启多能罐搅拌，使搅拌浆下降至底部，继续搅拌充分洗涤20min，然后通氮气进行压滤至多能罐视镜无液滴流出，压至多能罐的乙醇洗液。 ?重复上部过程再洗涤一次。两次乙醇洗涤液压至乙醇洗液储罐，下批投料用。 ?改用丙酮200kg，重复?的洗涤方法，洗液压至丙酮洗液储罐(下批投料使用)， arge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "threeo cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstrati2 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 尽量把溶媒压尽，则可转入干燥。 (5)干燥过程: ?启动真空泵(自动)，真空抽滤1h。 ?启动多能罐搅拌正转，搅拌速度为3.0，并以1.0的下降速度下降至底部。连续搅拌至温度不再下降，通入40?夹套水。 ?当多能罐内温度达到40??1?后，继续干燥40min，取样测水分。 ?如水分?3.0%，则通入冷却水循环，搅拌下使干品温度降至25?后出料。 (6)粉碎、过筛、罐装: ?在百级层流罩下，将密闭桶内头孢呋辛钠干品经粉碎机粉碎后，装入经灭菌的铝桶中，称重、充氮、封盖，并请检。 ?检验合格后，于外包装室进行外包装，办理寄仓手续。 ?凭成品入库放行单，办理成品交库手续，入合格品区。 (7)管路和设备清洗: ?每批生产完成后，先用纯化水对除菌过滤器后的管路、过滤器和设备进行清洗，再用注射用水进行清洗，用氮气吹干。 ?每连续生产一个月后(约20批)先用纯化水对除菌过滤器后的管路、过滤器和设备进行清洗，再用注射用水进行清洗，最后用纯蒸汽消毒。 ?设备清洗水应排向污水池，集中处理达标后排放。 ?每批生产完成后，应将活性炭冲洗至废炭池，沉积后集中罐装密封，送焚烧站焚烧处理。 (8)涉及的反应方程式: OOHOONaOOOOOOOOONNH2ONNH+NaOH+OH2N2sHNsHHHNHH3OCHNOCH3 (424.37)(446.37) (40)(18) -3- 头孢呋辛酸 氢氧化钠 乙醇 丙酮 钠盐溶液配置 头孢呋辛酸溶解 注射用水 注射用水 活性炭 脱 色 脱 色 活性炭 废活性炭 废活性炭 炭 脱 过 滤 炭 脱 过 滤 废气 废气 预 过 滤 预 过 滤 过 滤 过 滤 钠盐溶液滤清液 头孢呋辛酸滤清液 成 盐 结 晶 废气 过 滤 母 液 废气 乙醇 洗 涤 洗 液 丙酮 废气 抽滤、干燥 废液 粉尘 粉尘 粉碎过筛 去蒸馏回收 罐 装 回收液 残液 称 量 封 罐 外包装、寄仓 入 库 附图1 产品生产工艺流程 2.2 项目污染源强汇总 项目的“三废”汇总表见附表1。 o cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstratiarge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "three4 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 附表1 建设项目“三废”汇总表 污染物名称 产生量 削减量 排放量 丙酮 t/a 13.8 12.45 1.35 废气 乙醇 t/a 7.5 6.77 0.73 粉尘 t/a 0.15 0.147 0.003 3废水量 m/a 11010 0 11010 COD t/a 11.66 6.15 5.51(2.20) Cr废水 SS t/a 1.59 0 1.59(1.59) 氨氮 t/a 0.05 0 0.05(0.05) 废活性炭(HW06) t/a 5 5 0 残渣(HW06) t/a 6 6 0 回收液 t/a 611.7 611.7 0 固废 废渗透膜 t/a 0.1 0.1 0 废包装材料(HW06) t/a 25 25 0 职工生活垃圾(99) t/a 15 15 0 合计 t/a 662.27 662.27 0 -5- 3 选址周边环境及保护目标 3.1 周边环境概况 根据调查，该项目位于杭州湾精细化工园区，企业周边均为园区内化工厂，园区北面为钱塘江入海口，东面为余姚市，南面和西面为盖北镇和沥海镇农户种植的农作物，以水稻和其他经济性作物为主。据现场踏勘，项目所在地周围无地下水出口，也无大面积自然植被群落及珍稀动植物资源等。 3.2周边环境质量现状 (1)环境空气质量现状 3由监测资料可知，项目所在区域SO的小时平均浓度为0.025~0.132mg/m，NO的22 33小时平均浓度为0.011~0.088mg/m，PM的日均值范围为0.092~0.155mg/m，其中SO102和NO未超过《环境空气质量标准》(GB3095-1996)中的二级标准，PM仅一次超标，210超标原因主要是由于监测点周围建筑 施工 文明施工目标施工进度表下载283施工进度表下载施工现场晴雨表下载施工日志模板免费下载 和道路扬尘干扰引起的。 (2)地表水水质现状 根据2004年的监测资料，中心河、规划河和北塘河断面pH、DO、氨氮等指标均不能达到?类水体标准，而BOD、COD、石油类基本可达到?类水体标准，超标最5Mn 严重的为氨氮，中心河氨氮最大值为24.0mg/L(标准1.5mg/L)，规划河为45.3mg/L，北塘河为80.8mg/L。北塘河氨氮最大超标倍数达54倍。从指标上看，其主要污染指标有COD、总磷、氨氮、挥发酚，表明水体的主要污染是由有机类物质和氨氮等污Mn 染引起的。这说明园区内有部分企业废水渗漏入内河，另外农业面源污染也对园区内河水环境造成了影响。对比2005年3月的监测数据，园区内河的水质有明显的提高，2004年不能达标的污染因子pH、COD、总磷已全部能达标，DO、氨氮和BODMn5也明显有所降低，除个别指标外已接近?类水体标准。 由此可见，近年来在当地环保部门和园区管委会的努力下，化工园区内河水环境恶化趋势得到遏制，环境质量有较大提高。东盈医药和园区内其它化工企业排放的污水必须经过预处理达到进管标准再纳入园区污水管网，送上虞污水处理厂处理后达标排放。同时，在生产中应高度重视和警惕，严格管理，防止污水的事故排放。 (3)声环境现状 arge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "threeo cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstrati6 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 根据监测，项目拟建地四周环境噪声昼间在52.1dB,58.5dB之间，夜间在46.4dB,50.4dB之间，能满足功能区划的《城市区域环境噪声标准》标准3类区标准。 3.3 保护目标 1)水环境:地表水保护目标为精细化工园区内内河水质，保护级别按《地表水环境质量标准》(GB3838-2002)中的IV类。 2)环境空气:保护目标为建设区域周围的空气环境质量，保护级别为《环境空气质量标准》(GB3095-1996)二级。 3)声环境:保护目标为厂界的声环境质量，保护级别为《城市区域环境噪声标准》(GB3096-93)3类。 表2 主要保护对象一览表 序号 保护对象 方位 距离 规模 敏感性描述 1 世海村 S ,1.4km ,3476人 一般 2 盖北镇 SE ,2.0km ,2.57万人 一般 3 园区生活区 E ,800m ,300人 一般 -7- 4 环境影响分析 4.1 环境空气影响分析 根据预测可知，在主导风向、D类稳定度下工艺废气正常排放时，丙酮和乙醇最大 33落地贡献浓度分别为0.0664mg/m和0.0585mg/m，均远远小于各自浓度限值，比标值分别为0.083和0.012。可见贡献浓度都很小，因此对周围环境影响不大。 在主导风向、D类稳定度下工艺废气事故排放时，丙酮和乙醇废气最大落地贡献浓 33度分别为1.3091mg/m和0.9594mg/m，比标值分别为1.64和0.192。由此可见，在事故工况下，废气的排放对周围环境影响较大，因此建设单位必须确保废气处理设施的正常运行，杜绝非正常排放情况发生。 根据对敏感点的预测表明，本项目叠加其余厂家排放的废气后各污染物对周围环境敏感点基本没有影响，能达到功能区类别要求。 该项目卫生防护距离为50m，根据现场踏勘，项目拟建地周围50m的范围内基本为企业的厂区、道路以及周围的其它化工厂，敏感点在厂界1.5km以外，因此，该项目50m的卫生防护距离能够得到满足。 4.2 水环境影响分析 该项目工艺废水主要为管道及设备清洗废水、制纯水过程产生的浓水、精密过滤器冲洗废水、水冲泵废水和废气吸收后产生的废气处理废水，其他还有职工生活污水。空调系统、冷却系统排水和蒸汽系统冷凝水均作为清下水直接排放。废水经处理后全部排 3入园区污水处理厂。预计废水排放量为11010m/a，污染物排放量为COD5.51t/aCr(500mg/L)，SS1.59t/a(144mg/L)，氨氮0.05t/a(4mg/L)。 该项废水特点是有机物含量不高，成分较为简单，主要为乙醇、丙酮和少量头孢呋辛酸及头孢呋辛钠，可生化性较好，经厂内预处理后废水达标排放后对污水处理厂污染负荷及正常运行影响不大。由于废水不向园区内河排放，因此对内河水环境没有影响。 4.3 声环境影响分析 该项目噪声源较少，主要产噪设备为反应釜、真空泵、输料泵、废气处理装置的引 ,88dB之间。对各噪声源经减震、隔声降噪后该项目噪声对风机等，其噪声源强在75 周围环境影响不大。 o cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstratiarge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "three8 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 因此，该项目的实施对周围声环境影响不大。 4.4 固体废物影响分析 该项目固废主要为脱色和纯水制备过程产生的废活性炭、母液蒸馏回收后产生的残渣和回收液、纯水制备过程产生的废渗透膜，废包装材料及职工生活垃圾等。 其中废活性炭(约5t/a)和母液蒸馏回收后得到的残渣(约6t/a)均属危险废物，均委托由园区焚烧站焚烧处置。 母液回收得到的回收液611.17t/a则供仁和化工头孢呋辛酸前道生产使用。项目产生的废包装材料约25t/a，退回给原料供应商回收。废渗透膜约0.1t/a，退回给设备供应商统一回收利用。厂内职工产生的生活垃圾约15t/a，委托环卫部门统一清运。 该项目固体固废得到合理处置后，对周围环境影响不大。 -9- 5 对策措施 项目上马后，所需的污染防治措施见附表3。 表3 项目污染防治措施汇总 内容 排放源 污染物名称 防治措施 预期治理效果 类型 采用收集效率为95,的吸风罩收集后1、真空泵水箱 接入水喷淋塔处理后以15m高度排放 废气达标排放 2、空调系统排气口 大 接入水喷淋塔处理后以15m高度排放 丙酮和乙醇气 3、氮气管道排放口 废气 污 4、物料运输、管道严格管理，制定合理的操作规程，严格控制无组织废气的染 连接处等 施工，对管道常查常管 产生 物 5、贮罐呼吸口 采用水封处理 接入百级层流罩处理后以15m高度排6、密闭桶 粉尘 废气达标排放 放 7、设备及管道清洗 8、铝罐清洗 达到GB8978-96中9、精密过滤器冲洗 生产性废水 水 的(新扩改)三级10、废气吸收 经兼氧,好氧,二沉池处理 污 标准后排入园区污11、真空泵 水处理厂 染 12、制纯水过程 物 13、职工生活 生活污水 待事故处理完成后14、事故过程 事故废液 事故池暂存 再妥善处置 15、脱色过程 废活性炭 16、纯水制备过程 委托园区焚烧站焚烧处置 残渣 固 17、母液蒸馏回收供仁和化工头孢呋辛酸前道生产工序体 过程 回收液 资源化与无害化 使用 废 物 18、纯水制备过程 废渗透膜 退回给设备供应商统一回收 19、物料包装 废包装材料 退回给原料供应商回收 20、职工生活 生活垃圾 委托环卫部门统一清运 合计布置车间，对主要噪声源反应釜、真空泵、引风机等采取一定的隔声降噪措施，采取噪 有效减振和消声等措施、同时提高厂房门窗的密封性(整体声源可降2,5dB)，尽量降低厂界 噪声。 声 o cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstratiarge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "three10 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 6 总量控制及环境效益 6.1 总量控制 根据工程分析，该项目排放的污染因子中，纳入总量控制要求的主要污染物是COD、氨氮、粉尘以及特征污染物丙酮、乙醇。 Cr 根据达标排放原则，提出建设工程的总量控制指标见附表4。 表4 建设项目总量控制建议值 序号 项 目 建议值(t/a) 31 废水量 11010m/a 2 COD 5.51(2.20) Cr 3 氨氮 0.05(0.05) 4 工业粉尘 0.003 5 丙酮(气) 1.35 6 乙醇(气) 0.73 注:()内为经上虞污水处理厂处理后的排海排放总量。 项目污染物的排放总量控制建议值由企业向上虞市环保局申请，经审批同意后方能实施该项目。 6.2 环境效益 环境保护是我国的一项基本国策，近年来，国家在环保方面的投入也在逐年加大，目的就是为了不再走以牺牲环境来获取经济效益的老路。就浙江东盈药业有限公司来说，由于存在废气、废水、噪声和固体固废的影响，该项目上马后“三废”若不经过处理直接排入环境，将给周围环境造成一定的影响，且由于环境质量的恶化，也会带来种种负面影响(包括社会、经济、人文景观等);所以从表面上看，环境保护的一次性投入换得较好的环境质量，同时也有利于工厂本身长期的、健康的发展，在此同时也大大改善了周围环境质量，取得较好的社会经济效益，且这些效益也是无法估价的。因此，从环境经济损益上分析，环境所获得的效益远大于一次性的投入的经济损失，即环境效益显著。 -11- 7 环境可行性及评价结论 7.1 是否符合国家产业政策 根据《国家基本药物品种目录》(2002年)，该项目生产的头孢呋辛钠原药属国家基本药物品种目录中抗感染药部分。 且根据《医药行业“十五”规划》:“重点突破一批大宗原料药的关键生产技术，如β内酰胺类、维生素类、大环内脂类、氨基酸类产品及其中间体生产中的发酵、结晶及分离、提取等技术。开发一批有利于提高产品质量、提高产率、节能降耗、降低生产成本的共性技术”。 该项目所生产的头孢类原料药属第二类头孢，企业掌握了有机溶剂与水的配比技术，使该项目产品收率大大提高。 该项目生产的头孢类原料药未违反《关于加强全省工业项目新增污染控制的意见》浙政办发〔2005〕87号意见精神，符合浙江省产业政策。 因此，本项目建设符合国家及地方的产业政策。 7.2 是否符合城市环境功能区划和城市总体发展规划，做到合理布局 项目拟建地位于浙江杭州湾精细化工园区仁和化工现有厂区内。杭州湾精细化工园区主导产业为化工及医药产品，工业用地性质为三类，而本项目生产头孢类无菌原药，因此符合当地城市的总体规划和园区的产业导向。根据当地环境功能区划，厂址区域环境空气属二类功能区，水环境功能区划为IV类水体，声环境属3类功能区，可满足项目建设要求。 7.3 技术与装备政策是否符合清洁生产 本项目生产工艺技术在国内处于领先，采用的装备较先进，设备冷却水循环使用，使用的丙酮洗液、废母液等均可回收，符合“节能、降耗、减污、增效”的思想，因此，本项目的技术和装备基本能符合清洁生产要求。 7.4 是否做到污染物达标排放 本项目废气主要为有机溶剂废气，废水主要为设备及管道清洗水、精密过滤器冲洗水、废气吸收废水和真空系统排水等，固废主要为废活性炭、废母液、乙醇洗液、废包装材料等，噪声设备基本安置在厂房内，只要落实本环评提出的各项污染防治措施，污 o cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administrstratiarge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "three12 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) 染物均能达标排放。 7.5 是否满足国家和地方规定的污染物总量控制指标 3该项目污染物排放总量控制指标建议值废水量为11010m/a，COD为5.51t/a、氨Cr氮为0.05t/a、粉尘为0.003t/a、丙酮1.35t/a、乙醇为0.73t/a。具体排污总量必须由企业向上虞市环保局申请，经审批同意后方能实施该项目。 7.6 是否能维持地区环境质量，符合功能区要求。 经预测分析，项目上马后污染物经治理达标排放后对周围环境的贡献量较小，影响不大，当地环境质量仍能维持现状。 -13- 8 环评总结论 该项目选址于杭州湾精细化工园区内，项目建设符合国家和地方产业政策，符合上虞市总体规划及园区规划，项目基本符合清洁生产要求，项目产生的污染物经治理达标排放后对周围环境影响不大，对保护目标的影响甚小，周围环境仍能维持现状。 因此，从环保角度而言，该项目只要落实本次环评提出的各项治理措施，严格执行“三同时” 制度 关于办公室下班关闭电源制度矿山事故隐患举报和奖励制度制度下载人事管理制度doc盘点制度下载 ，确保污染物达标排放，加强环保管理，该项目在拟建厂址内实施是可行的。 stratiarge, poor business environment, it is ... ... Short Board, decide to change. We will continue to deepen reform of the adminio optimize government service. Low efficiency of government services, departments do not coordinate the views of businesses ld is tertake in a timely manner ... ... Transfer of the wood industry. This opportunity slip by, so the timing must be tight. SeconPark as the starting area of the industrial park, planners need to take out plan, start construction as soon as possible, undWood te the "road company" Park, industrial agglomeration. Currently, to focus on building better ... ... Industrial Park, ... ...etermine 1 leading industries, in particular stone Materials, cans, gloves, through guided, force and other measures to promok to dfrastructure, to achieve full coverage of infrastructure and interconnection with the facilities and raise capacity. Each park, to further improve the roads, power supply, communications, water supply and drainage and sewage pipe network and other inade, based on the original, and then extended the 6 square kilometers. Of the Parthree" Park. …… Industrial Park, according to ... ... The instructions of comrade, focus on development needs in the next dec-rAt present, we have formed a "threeo cancel, are not allowed to keep or disguised approval. To do list list of administrative powers and responsibilitieslear tative examination and approval matters, strengthen the existing supervision in matters of administrative power, has made it cve examination and approval system, good digestion, implement the Government canceled, adjustment and devolution of administr14 浙江东盈药业有限公司年产50吨头孢类无菌原料药GMP项目环境影响报告书(简本) -15-