下载
加入VIP
  • 专属下载特权
  • 现金文档折扣购买
  • VIP免费专区
  • 千万文档免费下载

上传资料

关闭

关闭

关闭

封号提示

内容

首页 Precision medicine

Precision medicine.doc

Precision medicine

周脱然
2019-06-14 0人阅读 举报 0 0 暂无简介

简介:本文档为《Precision medicinedoc》,可适用于医药卫生领域

PrecisionmedicineFromWikipedia,thefreeencyclopediaPrecisionmedicine(PM)isamedicalmodelthatproposesthecustomizationofhealthcarewithmedicaldecisions,practices,andorproductsbeingtailoredtotheindividualpatientInthismodel,diagnostictestingisoftenemployedforselectingappropriateandoptimaltherapiesbasedonthecontextofapatient’sgeneticcontentorothermolecularorcellularanalysisToolsemployedinPMcanincludemoleculardiagnostics,imaging,andanalyticssoftwareContentshideRelationshiptopersonalizedmedicineScientificbasesPracticeSeealsoReferencesRelationshiptopersonalizedmedicineeditInexplainingthedistinctionfromasimilarcommontermofpersonalizedmedicine,theNationalResearchCouncilexplains:PrecisionMedicinereferstothetailoringofmedicaltreatmenttotheindividualcharacteristicsofeachpatientItdoesnotliterallymeanthecreationofdrugsormedicaldevicesthatareuniquetoapatient,butrathertheabilitytoclassifyindividualsintosubpopulationsthatdifferintheirsusceptibilitytoaparticulardisease,inthebiologyandorprognosisofthosediseasestheymaydevelop,orintheirresponsetoaspecifictreatmentPreventiveortherapeuticinterventionscanthenbeconcentratedonthosewhowillbenefit,sparingexpenseandsideeffectsforthosewhowillnotAlthoughtheterm‘PersonalizedMedicine’isalsousedtoconveythismeaning,thattermissometimesmisinterpretedasimplyingthatuniquetreatmentscanbedesignedforeachindividualOntheotherhand,useoftheterm"precisionmedicine"aswellcanextendbeyondtreatmentselectiontoalsocovercreatinguniquemedicalproductsforparticularindividualsforexample,"patientspecifictissueororganstotailortreatmentsfordifferentpeople"Hence,theterminpracticehassomuchoverlapwith"personalizedmedicine"thattheyareoftenusedinterchangeablyScientificbaseseditOften,thoughnotnecessarily,PMinvolvestheapplicationofpanomicanalysisandsystemsbiologytoanalyzethecauseofanindividualpatient'sdiseaseatthemolecularlevelandthentoutilizetargetedtreatments(possiblyincombination)toaddressthatindividualpatient'sdiseaseprocessThepatient'sresponseisthentrackedascloselyaspossible,oftenusingsurrogatemeasuressuchastumorload(vtrueoutcomes,suchasyearsurvivalrate),andthetreatmentfinelyadaptedtothepatient'sresponseThebranchofprecisionmedicinethataddressescancerisreferredtoas"precisiononcology"Interpersonaldifferenceofmolecularpathologyisdiverse,soasinterpersonaldifferenceintheexposome,whichinfluencediseaseprocessesthroughtheinteractomewithinthetissuemicroenvironment,differentiallyfrompersontopersonAsthetheoreticalbasisofprecisionmedicine,the"uniquediseaseprinciple"emergedtoembracetheubiquitousphenomenonofheterogeneityofdiseaseetiologyandpathogenesisTheuniquediseaseprinciplewasfirstdescribedinneoplasticdiseasesastheuniquetumorprincipleAstheexposomeisacommonconceptofepidemiology,precisionmedicineisintertwinedwithmolecularpathologicalepidemiology(MPE)MPEresearchiscapableofidentifyingpotentialbiomarkersforprecisionmedicinePracticeeditAbilitytoprovideprecisionmedicinetopatientsinroutineclinicaltestingdependsontheavailabilityofmolecularprofilingtestsForexample,testindividualgermlineDNAManydifferentaspectsofprecisionmedicinearetestedinresearchsettings(eg,proteome,microbiom),butroutinepracticemaynotuseallavailableinputsAbilitytopracticeprecisionmedicineisalsodependentontheavailableknowledgebasesavailabletoassistclinicianintakingactionbasedontestresultsOnthetreatmentside,PMcaninvolvecustomizedmedicalproductssuchasbypharmacycompoundingorcustomizeddevicesItcanalsopreventharmfuldruginteractions,increaseoverallefficiencywhenprescribingmedications,andreducecostsassociatedwithhealthcareInhisStateoftheUnionaddress,USPresidentBarackObamastatedhisintentiontoinfusefundsintoaUnitedStatesnational"precisionmedicineinitiative"ExpandingcancergenomicsisashorttermgoalofthePrecisionMedicineInitiativetodevelopbetterpreventionandtreatmentmethodsformorecancersInthelongterm,thePrecisionMedicineInitiativeaimstobuildacomprehensivescientificknowledgebasebycreatinganationalnetworkofscientistsandembarkingonanationalcohortstudyofonemillionAmericanstoexpandourunderstandingofhealthanddiseaseSeealsoeditEvidencebasedmedicineMolecularmedicineMoleculardiagnosticsMolecularpathologyMolecularpathologicalepidemiologyPersonalizedmedicineUniquediseaseprincipleReferencesedit^Jumpupto:abTimmerman,Luke(February)"What’sinaNameALot,WhenItComesto‘PrecisionMedicine’"XconomyJumpup^ucsddbioprintingdtostoryhtmlJumpup^Jumpup^Blau,CA,Liakopoulou,E()"Canwedeconstructcancer,onepatientatatime"TrendsinGenetics():–doi:jtigJumpup^LeviAGarraway,JaapVerweijandKarlaVBallman()"PrecisionOncology:AnOverview"JClinicalOncology():–doi:jcoJumpup^OginoS,LochheadP,ChanAT,NishiharaR,ChoE,WolpinBM,MeyerhardtAJ,MeissnerA,SchernhammerES,FuchsCS,GiovannucciEMolecularpathologicalepidemiologyofepigenetics:emergingintegrativesciencetoanalyzeenvironment,host,anddiseaseModPathol:Jumpup^OginoS,FuchsCS,GiovannucciEHowmanymolecularsubtypesImplicationsoftheuniquetumorprincipleinpersonalizedmedicineExpertRevMolDiagn:Jumpup^OginoS,LochheadP,GiovannucciE,MeyerhardtJA,FuchsCS,ChanATDiscoveryofcolorectalcancerPIKCAmutationaspotentialpredictivebiomarker:powerandpromiseofmolecularpathologicalepidemiologyOncogeneadvanceonlinepublicationJunedoi:oncJumpup^Huser,VSincan,MCimino,JJ()"Developinggenomicknowledgebasesanddatabasestosupportclinicalmanagement:Currentperspectives"PharmacogenomicsandPersonalizedMedicine:–doi:PGPMSPMCPMIDeditJumpup^Jumpup^Jumpup^Jumpup^Neergard,Lauran(January)"ObamaProposes'PrecisionMedicine'toEndOneSizeFitsAll"DrugDiscoveryDevelopmentAssociatedPressJumpup^Jumpup^

用户评价(0)

关闭

新课改视野下建构高中语文教学实验成果报告(32KB)

抱歉,积分不足下载失败,请稍后再试!

提示

试读已结束,如需要继续阅读或者下载,敬请购买!

文档小程序码

使用微信“扫一扫”扫码寻找文档

1

打开微信

2

扫描小程序码

3

发布寻找信息

4

等待寻找结果

我知道了
评分:

/8

Precision medicine

VIP

在线
客服

免费
邮箱

爱问共享资料服务号

扫描关注领取更多福利