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首页 Science June 15 2012.pdf

Science June 15 2012.pdf

Science June 15 2012.pdf

上传者: zheng6822 2012-07-05 评分 0 0 0 0 0 0 暂无简介 简介 举报

简介:本文档为《Science June 15 2012pdf》,可适用于人文社科领域,主题内容包含CONTENTSVolumeIssuepages,,pageEDITORIALUNsustainableCarlosANobre>>PolicyFo符等。

CONTENTSVolumeIssuepages,,pageEDITORIALUNsustainableCarlosANobre>>PolicyForumpEssayspNEWSOFTHEWEEKAroundupoftheweek’stopstoriesNEWSANALYSISSocialScientistsHopeforReprieveFromtheSenateSeagrassesPartnerWithClamstoStayHealthy>>ReportpMicrobialSurveyofHumanBodyRevealsExtensiveVariationNEWSFOCUSHowDoYouCounttheDead>>SciencePodcastTheReluctantToadKillerLETTERSForgottenBiodiversityinDesertEcosystemsSMDurantetalPredatoryPublishersandPlagiarismPreventionPAJansenandPMForgetLifeinScience:PotatoPedagogyBBruckerCORRECTIONSANDCLARIFICATIONSBOOKSETALFinnishLessonsPSahlberg,reviewedbyHSaalbachIgnoranceSFirestein,reviewedbyMCerfPOLICYFORUMAvoidingEmptyOceanCommitmentsatRioLVeitchetal>>EditorialpEssayspPERSPECTIVESCOXInhibitorsandCardiovascularRiskCPCannonandPJCannonAbsoluteDatingofCaveArtJHellstrom>>ResearchArticlepCancerandTelomeresAnALTernativetoTelomeraseJWShayetalFragmentsoftheLunarCataclysmAERubin>>ReportpAllPackedUpandReadytoGoYJacobandRMartienssen>>ReportsppandTheHeartbeatofEcosystemsMAPalmerandCMFebria>>ReportpABoronBoronTripleBondGFrenkingandNHolzmann>>ReportpESSAYSScienceforSustainableDevelopmentAnalyzingSustainableDevelopmentGoalsLBritoTheUrbanChallengeDFiskHarnessingNewScientificCapacityAAbreuFromIndustrialTowardEcologicalinChinaJPanCreatingtheNewDevelopmentEcosystemADehganSystemsScienceforPolicyEvaluationPKabatRigorousEvaluationofHumanBehaviorEDuflo>>EditorialpPolicyForumpREVIEWTheFunctionsofBiologicalDiversityinanAgeofExtinctionSNaeemetalCONTENTScontinued>>wwwsciencemagorgSCIENCEVOLJUNECOVERViewofaceilinginAltamiraCave,Cantabria,Spain(originalimagerotated)Themulticolor(brownandred)bisondepictedheredateto~,yearsagobutwerepaintedontopofearliersinglecolorartwork(red)Newuraniumthoriumdatesoncalcitecrustsshowthatthelarge(~centimeter)doubleclaviformfigure(centerright)isatleast,yearsold,indicatingthat,atthelatest,cavepaintingherebeganshortlyafterhumansfirstarrivedSeepagePhoto:PedroSauraDEPARTMENTSThisWeekinScienceEditors’ChoiceScienceStaffNewProductsScienceCareersPublishedbyAAASCONTENTSpagespagespagesBREVIAMassivePhytoplanktonBloomsUnderArcticSeaIceKRArrigoetalInmidsummer,diatomshavetakenadvantageofthinningicecovertofeedinnutrientrichwatersRESEARCHARTICLEUSeriesDatingofPaleolithicArtinCavesinSpainAWGPikeetalDatingofcalcitecrustsoverlyingartinSpanishcavesshowsthatpaintingbeganmorethan,yearsago>>PerspectivepSciencePodcastREPORTSSpinOrbitEchoNSugimotoandNNagaosaAdistinctparameter,twistedspin,ispredictedtobeconservedinatwodimensionalsemiconductorwithspinorbitinteractionDipolarAntiferromagnetismandQuantumCriticalityinLiErFCKraemeretalScatteringexperimentsrevealthatmagneticorderingcanarisefromdipolarinteractions,notonlyfromexchangeAmbientTemperatureIsolationofaCompoundwithaBoronBoronTripleBondHBraunschweigetalAboronanalogofanalkynehasbeensynthesizedbyreductionofabrominatedprecursor>>PerspectivepReticulatedNanoporousPolymersbyControlledPolymerizationInducedMicrophaseSeparationMSeoandMAHillmyerInsitupreparationofablockcopolymercanbeusedtoinducemicrophaseseparationtomakemesoporousmaterialsDirectDetectionofProjectileRelicsfromtheEndoftheLunarBasin–FormingEpochKHJoyetalAnalysisoflunarrocksfromtheApollomissionsrevealsfragmentsfrommeteoritesthathittheMoonintheancientpast>>PerspectivepSparsePreColumbianHumanHabitationinWesternAmazoniaCHMcMichaeletalAnalysisofsoilsinwesternAmazoniafindslittleevidenceforpreColumbianhumanoccupationsthereAThreeStageSymbiosisFormstheFoundationofSeagrassEcosystemsTvanderHeideetalAmarineplant,smallmollusks,andtheirresidentsulfideoxidizingbacteriasurvivetogether>>NewsstorypFearofPredationSlowsPlantLitterDecompositionDHawlenaetalTheriskofbeingeatenbyspiderschangestheelementalcompositionofgrasshoppers,whichaffectssoilmicrobes>>SciencePodcastContinentalScaleEffectsofNutrientPollutiononStreamEcosystemFunctioningGWoodwardetalLeaflitterbreakdownratesacrossEuropeanstreamsofferinsightsintoecosystemhealthduringeutrophication>>PerspectiveppDynamicsControlCellFateJEPurvisetalAfterDNAdamage,pulsesofpallowrecovery,whereassustainedlevelsleadtosenescenceAHistoneAcetyltransferaseRegulatesActiveDNADemethylationinArabidopsisWQianetalAplantepigeneticregulatorrecognizesbothhistonesandmethylatedDNAandpreventsgenesilencingMORCFamilyATPasesRequiredforHeterochromatinCondensationandGeneSilencingGMoissiardetalAconservedfamilyofadenosinetriphosphatasespredictedtocatalyzealterationsinchromosomesuperstructureisrequiredforgenesilencing>>PerspectivepTheStructuresofCOPICoatedVesiclesRevealAlternateCoatomerConformationsandInteractionsMFainietalTheflexiblecoatomercomplexmakescontactwithavariablenumberofneighborsandcoatsvesiclesofvariablesizeAwakeHippocampalSharpWaveRipplesSupportSpatialMemorySPJadhavetalTheneuronal“replay”ofpastexperiencemayallowanimalstoretrievespecificmemoriesandusethemtoguidebehaviorSegregationofAxonalandSomaticActivityDuringFastNetworkOscillationsTDugladzeetalInhibitionbyaxoaxonicinterneuronsfunctionallyseparatestheinputandoutputofhippocampalpyramidalcellsJUNEVOLSCIENCEwwwsciencemagorgCREDITS:(MIDDLE)USRALPICLSEKATHERINEJOY(BOTTOM)LAURALGOVERSPublishedbyAAASwwwsciencemagorgSCIENCEVOLJUNECONTENTSSCIENCEXPRESSwwwsciencexpressorgUniversities,KeytoProsperityCOHollidayscienceAdenylateCyclasesofTrypanosomabruceiInhibittheInnateImmuneResponseoftheHostDSalmonetalParasitesreleasecyclicadenosinemonophosphatewhenswallowedupbymyeloidcells,therebyturningoffahostdefensepathwayscienceFunction,Targets,andEvolutionofCaenorhabditiseleganspiRNAsMPBagijnetalPiwiboundpiwiinteractingRNAsrecruitendogenoussmallinterferingRNAstosilencemobilegeneticelementsscienceRapidProgressionofOceanAcidificationintheCaliforniaCurrentSystemNGruberetalRisingconcentrationsofatmosphericcarbondioxidethreatentoamplifytheseverityofoceanacidificationinupwellingzonesscienceMitochondrialImportEfficiencyofATFSRegulatesMitochondrialUPRActivationAMNargundetalWhenstressed,themitochondrionreducesimportofatranscriptionfactor,whichentersthenucleusinsteadscienceSCIENCENOWwwwsciencenoworgHighlightsFromOurDailyNewsCoveragePuttingtheBrakesontheImmuneSystemResearchersdiscoverpowerfulbutshortlivedcellsthatreininimmuneattackshttp:scimagImmuneBrakesAgingIsRecordedinOurGenesAswegrowolder,weloseDNAmodificationsthatcanprotectagainstcancerandotherdiseaseshttp:scimagAgeGenesLifeBloomsUnderArcticIceResearchersdiscovergreenbloomsofphytoplanktonmorethanonemeterbelowthesurfacehttp:scimagIceBloomsSCIENCEONLINESCIENCE(ISSN)ispublishedweeklyonFriday,exceptthelastweekinDecember,bytheAmericanAssociationfortheAdvancementofScience,NewYorkAvenue,NW,Washington,DCPeriodicalsMailpostage(publicationNo)paidatWashington,DC,andadditionalmailingofficesCopyrightbytheAmericanAssociationfortheAdvancementofScienceThetitleSCIENCEisaregisteredtrademarkoftheAAASDomesticindividualmembershipandsubscription(issues):$($allocatedtosubscription)Domesticinstitutionalsubscription(issues):$Foreignpostageextra:Mexico,Caribbean(surfacemail)$othercountries(airassistdelivery)$Firstclass,airmail,student,andemeritusratesonrequestCanadianrateswithGSTavailableuponrequest,GST#PublicationsMailAgreementNumberPrintedintheUSAChangeofaddress:Allowweeks,givingoldandnewaddressesanddigitaccountnumberPostmaster:SendchangeofaddresstoAAAS,POBox,Washington,DC–Singlecopysales:$currentissue,$backissueprepaidincludessurfacepostagebulkratesonrequestAuthorizationtophotocopymaterialforinternalorpersonaluseundercircumstancesnotfallingwithinthefairuseprovisionsoftheCopyrightActisgrantedbyAAAStolibrariesandotherusersregisteredwiththeCopyrightClearanceCenter(CCC)TransactionalReportingService,providedthat$perarticleispaiddirectlytoCCC,RosewoodDrive,Danvers,MATheidentificationcodeforScienceisScienceisindexedintheReader’sGuidetoPeriodicalLiteratureandinseveralspecializedindexesSCIENCESIGNALINGwwwsciencesignalingorgTheSignalTransductionKnowledgeEnvironmentJuneissue:http:scimagssRESEARCHARTICLE:TheTranscriptionFactorTFEBLinksmTORCSignalingtoTranscriptionalControlofLysosomeHomeostasisARoczniakFergusonetalPODCASTSMFergusonandAMVanHookRegulatednucleartranslocationofatranscriptionfactormaintainslysosomalhomeostasisRESEARCHARTICLE:ThelinMicroRNATargetstheLINTranscriptionFactortoInhibitNetrinMediatedAxonAttractionYZouetalAmicroRNAinstructsneuronswhentostopaxonalpathfindingPERSPECTIVE:SNitrosylationSignalinginEscherichiacoliIGusarovandENudlerTwoposttranslationalmodificationsofatranscriptionfactorenablebacteriatoadapttochangesinNOandOSCIENCETRANSLATIONALMEDICINEwwwsciencetranslationalmedicineorgIntegratingMedicineandScienceJuneissue:http:scimagstmEDITORIAL:Listen,Understand,EngageAThomsonandMWatsonFormoreeffectivevaccineadvocacy,scientistsandpolicymakersmusttranslateandapplyinsightsfromthecognitiveandsocialsciencestothewaytheycommunicateandengagewiththepublicRESEARCHARTICLE:CellCarriage,Delivery,andSelectiveReplicationofanOncolyticVirusinTumorinPatientsRAAdairetalFOCUS:TheVirusThatCameinfromtheColdJCBellOncolyticreovirusiscarriedbycellstotumorsandprotectedfromneutralizingantibodiesinthecirculationRESEARCHARTICLE:MyocardialInfarctionTriggersChronicCardiacAutoimmunityinTypeDiabetesRVSRKGottumukkalaetalFOCUS:AutoimmuneDiabetesInflamestheHeartRHEckelandGSEisenbarthAcutemyocardialinfarctiontriggersanautoimmuneattackontheheartinamousemodeloftypediabetesandinhumantypediabeticpatientsRESEARCHARTICLE:ExomeSequencingCanImproveDiagnosisandAlterPatientManagementTJDixonSalazaretalExomesequencingofpatientswithneurodevelopmentaldisordersshowsthatthistechniqueisusefulforidentifyingnewpathogenicmutationsandforcorrectingdiagnosisin~ofcasesRESEARCHARTICLE:MucusPenetratingNanoparticlesforVaginalDrugDeliveryProtectAgainstHerpesSimplexVirusLMEnsignetalMucuspenetratingparticlesimprovedrugdeliverytothemucosalsurfaceofthemousevaginaanddeliveracyclovirforenhancedprotectionagainstvaginalherpesinfectioninmiceRESEARCHARTICLE:SuccessfulTreatmentofEbolaVirus–InfectedCynomolgusMacaqueswithMonoclonalAntibodiesXQiuetalMacaquessurvivedinfectionwithEbolaviruswhentreatedstartingathoursafterinfectionwithamixofthreeneutralizingmonoclonalantibodiesSCIENCECAREERSwwwsciencecareersorgcareermagazineFreeCareerResourcesforScientistsSoldiersBecomingScientistsMPriceThePostGIBillandotherprogramsareenablingsomeveteranstopursuecareersinsciencehttp:scimagSoldierScientistsToolingUp:InterviewIntangiblesDJensenThemostimportantaspectsofyourjobinterviewarethingsyoumaynothavethoughtabouthttp:scimagTUIntangiblesSCIENCEPODCASTwwwsciencemagorgmultimediapodcastFreeWeeklyShowOntheJuneSciencePodcast:stressedoutgrasshoppers,anewwaytodatecavepaintings,countingthedeadonaglobalscale,andmoreSCIENCEINSIDERnewssciencemagorgscienceinsiderSciencePolicyNewsandAnalysisPublishedbyAAASEDITEDBYSTELLAHURTLEYCREDITS(TOPTOBOTTOM):JEREMYPURVISHARVARDMEDICALSCHOOLSUGIMOTOETALEnvironmentalDeterminismEarth’smillionsofspeciesinfluenceawiderangeofenvironmentalprocesses,includingelementalcycling,thestabilityofecosystems,andthegoodsandservicestheyprovideNaeemetal(p)reviewrecentadvancesintheyoungandevolvingfieldofbiodiversityandecosystemfunctioning,exploretheextenttowhichthefieldisbecomingapredictivescience,andindicatehowthefieldneedstodevelopinordertoaidworldwideeffortstoachieveenvironmentalsustainabilityinthefaceofrisingratesofextinctionDatingCavePaintingsAnumberofcavesinEuropecontainexquisiteancientartMostofthearthasbeenthoughttobeproducedduringthetimeoflastglaciationbyrecentlyarrivedmodernhumans,butdatingofthearthasbeenproblematicbecausetheartcontainsonlyminimalamountsofcarbonforradiocarbondatingPikeetal(pseethecoverseethePerspectivebyHellstrom)havenowobtainedUseriesdatesonthecalcitecruststhatformedovertheartfromcavesinnorthwesternSpainTheagesfromthreecavesareolderthan,yearsago,andonedatestonearly,yearsagoTheearliestartusedprimarilyredandwasrelativelyformlessanimaldepictionsappearedlaterThisdatingisnearthetimeofthearrivalofmodernhumansand,becauseNeandertalswerealsopresent,complicatesidentifyingtheartistsSpinRecoverySpinorbitinteractionspresentinmanysemiconductorsareusedtomanipulatethespinofanelectroninspinbasedelectronicsHowever,thissameinteractionisalsoresponsibleforthelossofinformationcontainedinaspinwhenitchangesitsdirectionduringthescatteringoffofimpuritiesSugimotoandNagaosa(p)describeanewquantity,twistedspin,which,unlikeregularspin,survivesthescatteringsmoreover,becausethespinorbitinteractionisturnedoffadiabatically,thelostspininformationisretrievedDroppingaDimensionInmostmagneticmaterials,theexchangeinteractioncausesthespinsontheneighboringsitesofacrystallatticetoalignIntheabsenceofexchangeinteractions,dipolarinteractions,whicharehighlyorientationdependent,arealsoexpectedtobeabletocausemagnetismKraemeretal(p)presentevidenceforantiferromagnetisminadipolarcoupledmaterial,LiErFAlthoughathreedimensionalsystem,itscriticalbehaviorwasmorereminiscentofatwodimensionalmaterialBBBondAlkynescontaincarboncarbontriplebondsandrepresentadiverseclassoforganiccompoundsInprinciple,valencerulessuggestthattheboronanalogofanalkyne,withaBBtriplebond,oughttobeaccessiblebyappendingatwoelectrondonortoeachBatomBraunschweigetal(pseethePerspectivebyFrenkingandHolzmann)nowpresentthesynthesis,isolation,andcrystallizationofasolid,triplebondeddiboryne,withNheterocycliccarbenesastheterminalsubstituents,whichcontainstheexpectedlinearbondinggeometryPorousBlocksPorousmaterialsarewidelyusedinseparationprocessesandcatalysisSeoandHillmyer(p)usedblockcopolymersthatnaturallyseparateintodomainstoachieveacontinuousnetworkofporesAchaintransferagentwasusedtodirectthecopolymerizationofthetwomaterialsinsitutogenerateastructurewithapercolatingporousstructurewithporesizesofafewnanometersandwithtunablecontroloverthepolymerpropertiesandextentofcrosslinkingTheRocksThatHittheMoonThecrateredsurfaceoftheMoonbearswitnesstothenumerousimpactsithassufferedChemicalsignaturesoftheseimpactshavebeendetectedindirectlyNow,Joyetal(p,publishedonlineMayseethePerspectivebyRubin)reportthedetectionandcharacterizationofmeteoritefragmentspreservedinancientlunarregolithbrecciasfromtheApollolandingsiteThesemeteoriticfragmentsrepresentdirectsamplesofthepopulationofsmallbodiestraversingtheinnersolarsystemataroundbillionyearsagothesametimeorjustafterthebasinformingepochontheMoonAncientAssociationsSubmarineseagrassmeadowsarecriticaltofisheriesandcoastlineprotectionandprovidefeedinggroundsformanyendangeredspecies,includingdugongsandturtles,andserveasanurseryforcoralreeffishThepersistenceandmaintenanceofseagrassecosystemshavebeenmysterious,becauseaccumulationoforganicmatterinthebedsshouldrapidlyleadtotoxicsulphidelevelsinthesedimentUsingametaanalysisandafieldstudy,vanderHeideetal(p)atttributethemillionyearsuccessofseagrassestoathreestagesymbiosisSeagrassbedsworldwidecontainhighdensitiesofsmalllucinidbivalvesthathavesymbioticDynamicResponses>>ExpressionofthetumorsuppressorpisactivatedinresponsetocellstressThedynamicsofpactivationcanvary,dependingonthestressor,resultingineitherpulsatileorconstantplevelshowever,thefunctionalconsequenceofthesedifferentdynamicsisunclearPurvisetal(p)developedamethodtocontrolpdynamicsinhumancellsPulsingpselectivelyactivatedgenesinvolvedincellcyclearrestandDNArepair,allowingrecoveryfromDNAdamageIncontrast,sustainedppromotedinductionofterminalgenesleadingtocellularsenescenceThus,proteindynamicscanaffectcellfatedecisionsJUNEVOLSCIENCEwwwsciencemagorgPublishedbyAAASonJune,

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