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1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
PROBLEM SOLVING IN MUSCULOSKELETAL IMAGING ISBN: 978-0-323-04034-1
Copyright © 2008 by Mosby, Inc., an imprint of Elsevier Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by
any means, electronic or mechanical, including photocopying, recording, or any information storage
and retrieval system, without permission in writing from the publisher. Permissions may be sought
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(U.K.); fax: (+44) 1865 853333; e-mail: healthpermissions@elsevier.com. You may also complete your
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Knowledge and best practice in this fi eld are constantly changing. As new research and experience
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law, neither the Publisher nor the Authors assume any liability for any injury and/or damage to
persons or property arising out of or related to any use of the material contained in this book.
Library of Congress Cataloging-in-Publication Data
Morrison, William B.
Problem solving in musculoskeletal imaging / William B. Morrison, Timothy G. Sanders.—1st ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-323-04034-1
1. Musculoskeletal system—Imaging. 2. Musculoskeletal System—Diseases—Diagnosis.
3. Problem solving. I. Sanders, Timothy G. II. Title.
[DNLM: 1. Musculoskeletal Diseases—diagnosis. 2. Magnetic Resonance
Imaging—methods. 3. Musculoskeletal System. WE 141 M883p 2008]
RC925.7.M68 2008
616.7′075—dc22
2007042922
Acquisitions Editor: Rebecca Gaertner
Developmental Editor: Elizabeth Hart
Project Manager: Mary Stermel
Design Direction: Steven Stave
Marketing Manager: Catalina Nolte
Printed in China.
Last digit is the print number: 9 8 7 6 5 4 3 2 1
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Kenneth A. Buckwalter, MD
Professor
Department of Radiology
Indiana University School of Medicine
University Hospital
Indianapolis, IN
Angela Gopez, MD
Assistant Professor
Department of Radiology
Thomas Jefferson University Hospital
Philadelphia, PA
Eoin C Kavanagh, MRPCI, FFR, RCSI
Consultant Radiologist and Senior Lecturer
Mater Misericordiae Hospital
Dublin, Ireland
W. James Malone, DO
Academic Chief, Musculoskeletal Imaging
Department of Radiology
Geisinger Medical Center
Danville, PA
Levon N. Nazarian, MD, FACR
Professor and Vice Chairman for Education
Department of Radiology
Thomas Jefferson University Hospital
Philadelphia, PA
Imran M. Omar, MD
Assistant Professor
Department of Radiology
Northwestern Memorial Hospital
Chicago, IL
Paul Shieh, MD
Staff Radiologist
Community Medical Center
Saint Barnabas Health Care System
Toms River, NJ
Adam C. Zoga, MD
Associate Professor
Department of Radiology
Thomas Jefferson University Hospital
Philadelphia, PA
Contributors
v
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vii
Preface
The “Problem Solving” series by Elsevier is a new type
of teaching tool: a series of texts in different disci-
plines that strive to distill the authors’ experience and
approach to clinical challenges rather than merely
index the imaging appearance of injury and disease.
This format is diffi cult to achieve in all areas, and
therefore texts within this series will incorporate dif-
ferent variations of this concept. Our musculoskeletal
edition, for example, is roughly divided into three
areas: technical issues and optimization, approach to
musculoskeletal diseases, and advanced joint imaging.
The fi rst technical chapter teaches a practical meth-
odology for improving image quality across modali-
ties, as well as providing examples of how the
radiologist can use the modality to answer specifi c
clinical questions. The attached CD is an extension
of this chapter; it includes material that aids the radi-
ologist in day-to-day clinical operations—patient
questionnaires, dictation templates, and MRI/CT pro-
tocols, including pictorial examples of positioning
and plane selection. Additional chapters provide
instruction on performance of arthrography and
bone/soft tissue biopsy.
The approach chapters address general categories
of disease, including arthritis, tumor and infection;
these chapters attempt to provide the reader with tips
and thought processes associated with diagnosis of
these conditions.
The joint-oriented chapters strive to teach the
reader how to interpret advanced imaging studies on
a high level, similar to a dedicated musculoskeletal
radiologist. Figures are formatted in an easy-to-read
way analogous to a PowerPoint slide rather than tra-
ditional book fi gures with dozens of arrows and long
legends.
Problem Solving in Musculoskeletal Imaging is
intended to be read cover-to-cover. The entire work is
an effort to enable readers to “get into the mind” of
a bone radiologist, so that they may provide high-
level service to their patients and referring clinicians.
We hope that we have achieved this goal. We are
eternally grateful to our teachers and contributors
who helped make this book a reality.
William B. Morrison, MD
Timothy G. Sanders, MD
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ix
Acknowledgments
I am very grateful to David Karasick, MD, Diane Deely, MD, and Alex Dresner,
PhD, for lending me their extensive expertise. I am also indebted forevermore
to David and Diane, as well as Mark Schweitzer, MD, for providing teaching,
mentoring, and continuing support throughout my career. All my other teachers,
colleagues, and friends deserve credit for their guidance—you know who you
are—your martini is waiting!
Thanks to dancers Phil Colucci and Emily Hayden of the Pennsylvania Ballet
for modeling arthrographic technique. Special thanks to Anne Dugan for her
assistance.
—WBM
I would like to acknowledge two very special mentors and friends, Robert Miller,
MD, at the University of Florida for fi rst sparking my interest in musculoskeletal
radiology, and Phillip Tirman, MD, for helping to jumpstart my academic career.
My time in radiology has been much richer as a result of these two individuals.
I would like to acknowledge the entire Air Force community: for the fun, the
education, and the varied opportunities during 25 great years.
Finally, I would like to thank my family; my parents for their steadfast support
throughout the years, and of course my wife, DeAun, and daughters, Kelly and
Courtney, for their continued understanding and support during the prepara-
tion of this book.
—TGS
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CHAPTER OUTLINE
Magnetic Resonance Imaging 4
High-Field versus Low-Field Scanners 4
Advantages and Disadvantages of 3 T Scanners for
Musculoskeletal Imaging 7
Coils 8
Imaging Sequence Selection 8
Spatial Resolution versus Contrast—Which to
Choose? 8
Spin-Echo Imaging 11
Fast Spin-Echo Imaging 11
Short Tau Inversion Recovery 13
Gradient-Echo Imaging 14
MR Arthrography 17
Optimizing Signal-to-Noise Ratio 18
How to Reduce Artifacts Seen on
Musculoskeletal MR Imaging 24
Artifacts Related to Fat Suppression 24
Artifacts Related to Motion 26
Blur Artifact 28
Artifacts Related to Signal Loss: Field Cutoff/Coil
Malposition 29
Magic Angle Phenomenon 29
Magnetic Susceptibility Artifact 30
Chemical Shift Misregistration Artifact 32
Using Artifacts to Your Advantage 33
How to Take Advantage of Magnetic Susceptibility
Artifact 33
How to Take Advantage of Chemical Shift
Artifact 34
Special Planes/Positions 34
Computed Tomography 36
Basics of Multidetector CT 36
Musculoskeletal Ultrasound 47
Chapter 1
OPTIMIZATION OF CLINICAL
MUSCULOSKELETAL IMAGING
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Section I ADVANCED MODALITIES: Protocols and Optimization4
MAGNETIC RESONANCE
IMAGING
When protocols are created or altered for musculo-
skeletal magnetic resonance (MR) imaging examina-
tions, consideration should be given to the type of
MR scanner being used (e.g., high fi eld or low fi eld),
available surface coils and their confi gurations, and
technologist experience. Beyond that, thought should
be given to what specifi c information is needed from
the examination, taking into account the clinical
history and what is the appropriate fi eld of view to
answer the question. Is high spatial resolution
required to answer the question, or is high contrast
between structures more important? Planes and
sequences should be selected to optimize relevant
anatomy and pathology, optimizing signal-to-noise
ratio (SNR). Finally, consideration should be given as
to whether intravenous or intra-articular contrast is
necessary, and whether any specialized sequences,
planes, or positions would be advantageous. This
section deals with each of these issues in addition to
artifacts and their minimization. Sample protocols
with suggested plane selection are available on the
accompanying CD.
High-Field versus Low-Field Scanners
Scanners come in a variety of fi eld strengths, and
options are available for various gradient strengths
and slew rates intended to optimize scanning. Soft-
ware options are often available at additional cost.
These issues can cause confusion when selecting a
scanner for purchase. In addition, different manufac-
turers have different terminology for sequences,
magnet homogeneity, and other physical features
that make it diffi cult to perform an “apples to apples”
comparison. However, rarely does musculoskeletal
imaging come into consideration when purchasing a
scanner. Typically, neurologic and body imaging
applications are those that guide scanner selection
and purchase, and musculoskeletal imaging is a sec-
ondary consideration. A basic understanding of MR
physics principles is generally all that is needed to
optimize musculoskeletal imaging protocols, no
matter what machine is used. The differences between
high-fi eld and low-fi eld scanners are extremely impor-
tant in musculoskeletal imaging; advantages and dis-
advantages are summarized in Table 1-1.
Low-fi eld scanners, that is, lower than 0.7 tesla (T),
have diffi culty performing standard presaturation-
type frequency selective fat suppression because the
signal peaks for the protons in water and fat are
closely approximated. This is very important because
musculoskeletal radiologists generally prefer to apply
fat suppression on T2-weighted images to highlight
fl uid and edema. In addition, because fat is ubiqui-
tous in the musculoskeletal system, fat suppression is
preferred when gadolinium is injected intravenously
or into a joint. As such, this can be a signifi cant limi-
tation of low-fi eld scanners. Instead of T2-weighted
fast spin-echo fat-suppressed imaging, which is a
standard in musculoskeletal radiology, short tau
inversion recovery (STIR) imaging is used to achieve
fl uid conspicuity, but at the expense of lowered reso-
lution or a larger fi eld of view. Alternatively, fl uid
conspicuity can be achieved without fat suppression
by increasing echo time (TE), about 100 to 120 msec.
However, this is at the expense of the SNR, which
decreases as TE is raised. This creates diffi culty in
visualizing small cartilage lesions. One should not
expect to consistently see small cartilage defects on a
low-fi eld scanner.
Without fat suppression on T1-weighted images,
visualization of intravenously or intra-articularly
administered contrast can be diffi cult, limiting appli-
cations such as tumor/infection imaging and MR
arthrography. Also, there is relatively lower signal
overall. To compensate, this requires increasing the
number of signal averages to increase signal at the
expense of increased imaging time, which can increase
motion artifact in the extremities. Length of examina-
tions is generally much greater on low-fi eld scanners
and may not be as useful for uncooperative patients.
Coil options are often limited on low-fi eld scanners,
with a small variety of multipurpose surface coils
available for imaging various musculoskeletal struc-
Table 1-1 Low-Field MRI: Advantages and
Disadvantages
Advantages
Lower magnetic susceptibility artifact
High T1 contrast
Ease of positioning
Obese patients (up to 500-pound weight limit)
Eccentric body parts easier to center
Disadvantages
Diffi culty performing “standard” fat suppression
Lower overall signal—longer scan times needed (motion
artifact can be an issue)
Low resolution (imaging of cartilage, small structures such as
labrum limited)
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Chapter 1 OPTIMIZATION OF CLINICAL MUSCULOSKELETAL IMAGING 5
tures. This can result in an inappropriately large fi eld
of view and low resolution.
Nevertheless, there are some advantages to muscu-
loskeletal imaging on low-fi eld scanners. T1 contrast
is actually superior to that of high-fi eld scanners,
although this is a relatively minor advantage in prac-
tice; in fact, improved T1 contrast can be disadvanta-
geous. Consider evaluation of the knee on a low-fi eld
system; on a T1-weighted sequence fl uid may appear
black, blending with signal of the menisci (Fig. 1-1).
Because of lower fi eld strength, artifact from metal
may be decreased compared with high-fi eld scanners,
and imaging patients who have prostheses, screws, or
other orthopedic hardware can actually be improved
by directing these patients to a low-fi eld scanner.
Keep in mind that advances in gradient technology
at high fi elds have offset many of these advantages
for high-fi eld scanners. Chemical shift artifact is also
decreased at low fi eld.
Moreover—and what is possibly the most impor-
tant consideration—is the gantry size and table weight
limit of low-fi eld scanners, which generally offer an
open environment and a weight limit of up to 500
pounds. For obese patients, no other imaging options
may be available. This is mainly an issue in the United
States. Regarding fat suppression, many low-fi eld
scanners offer a software option based on the Dixon
technique, which acquires an in-phase and out-of-
phase image, and through subtraction post-process-
ing, obtains a fat-suppressed image (Fig. 1-2). If the
subtraction is performed from images acquired in
the same series no subtraction errors occur, and the
images and degree of fat suppression are generally
excellent. In fact, if the radiologist’s intention is to
perform MR arthrography on a low-fi eld scanner,
strong consideration should be given to acquiring
this post-processing software. Newer generations of
low-fi eld scanners can actually separate the fat and
water peaks, performing true fat saturation, but this
has been suboptimal compared with the Dixon
technique.
Extremity scanners are also available, which are
generally low fi eld at about 0.2 T; although they are
low cost and provide a high degree of patient comfort,
low image quality corresponds to the low strength.
Also, the narrow bore of the magnet limits scanning
Discoid meniscus with tear?
Fluid can be black on
T1w images on low-
field scanners,
similar to signal
of meniscus
STIR
No
T1
Figure 1-1 0.3 T MRI of the knee. Low-fi eld scanners have better T1 contrast than high-fi eld units. However, this can
have a detrimental effect on joint imaging.
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Section I ADVANCED MODALITIES: Protocols and Optimization6
Susceptibility artifact from
prior rotator cuff repair
In-phase
Fatty marrow retains
signal on out-of-phase
Red marrow loses
signal on out-of-phase
Out-of-phase
Partial-thickness
undersurface retear
Gadolinium
stands out
Fat-
suppressed
Black muscle, black fluid characterize a water-suppressed image
Water-
suppressed
Figure 1-2 MR arthrogram on a 0.3 T system. Dixon technique for fat-water separation. An in-phase and out-of-
phase image is acquired (useful for marrow evaluation) as well as a fat-suppressed and a water-suppressed image. The fat-
suppressed image is ideal for use in MR arthrography on low-fi eld scanners. However, as a gradient-echo sequence, it is
prone to susceptibility artifact from metal, air, blood products, and calcium.
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Chapter 1 OPTIMIZATION OF CLINICAL MUSCULOSKELETAL IMAGING 7
to wrists/hands, elbows, ankles/feet and knees.
However, a 1.0 T extremity scanner is available that
provides good image quality comparable to that
achieved with closed 1.5 T scanners (Fig. 1-3). Other
open confi guration 1.0 T scanners are also available.
Advantages and Disadvantages of 3 T
Scanners for Musculoskeletal Imaging
There are some distinct advantages of 3 T MRI for
musculoskeletal imaging. The high fi eld strength pro-
vides high SNR over all imaging sequences, allowing
an increase in the matrix, a decrease in slice thickness,
and a decrease in fi eld of view, providing increased
resolution; ultimately, high resolution is a major key
to success in musculoskeletal radiology (Fig. 1-4).
Alternatively, one can use the signal surplus to
decrease number of excitations (NEX), thereby short-
ening examination time and increasing patient
throughput. However, protocols must be altered
somewhat to account for the different physical prop-
erties of the 3 T environment. For example, the high
fi eld strength at 3 T accentuates susceptibility artifact
from metal, limiting evaluation of orthopedic hard-
ware. In addition, chemical shift artifacts may be
increased, resulting in black-white effect at fat–water
Triangular
fibrocartilage tear
Figure 1-4 High-resolution 3 T imaging of the thumb using a small solonoid coil. Improved knowledge of
anatomic detail and microstructural pathology will be required once this degree of resolution is routinely achieved.
(Courtesy of Ivan Dimitrov, Best, the Netherlands, Philips.)
Figure 1-3 Coronal gradient-recalled echo image of
the wrist acquired with a 1.0-T dedicated extremity
scanner. (Courtesy of ONI and Joel Newman, Boston,
MA.)
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Section I ADVANCED MODALITIES: Protocols and Optimization8
interfaces. This can be eliminated if fat suppression
is used; alternatively, one can make the pixels smaller
to reduce this artifact by increasing