加入VIP
  • 专属下载特权
  • 现金文档折扣购买
  • VIP免费专区
  • 千万文档免费下载

上传资料

关闭

关闭

关闭

封号提示

内容

首页 Biochemistry 5th ed

Biochemistry 5th ed .pdf

Biochemistry 5th ed

UC
2011-10-24 0人阅读 举报 0 0 暂无简介

简介:本文档为《Biochemistry 5th ed pdf》,可适用于工程科技领域

DedicationAbouttheauthorsPrefaceToolsandTechniquesClinicalApplicationsMolecularEvolutionSupplementsSupportingBiochemistry,FifthEditionAcknowledgmentsITheMolecularDesignofLifePrelude:BiochemistryandtheGenomicRevolutionDNAIllustratestheRelationbetweenFormandFunctionBiochemicalUnityUnderliesBiologicalDiversityChemicalBondsinBiochemistryBiochemistryandHumanBiologyAppendix:DepictingMolecularStructuresBiochemicalEvolutionKeyOrganicMoleculesAreUsedbyLivingSystemsEvolutionRequiresReproduction,Variation,andSelectivePressureEnergyTransformationsAreNecessarytoSustainLivingSystemsCellsCanRespondtoChangesinTheirEnvironmentsSummaryProblemsSelectedReadingsProteinStructureandFunctionProteinsAreBuiltfromaRepertoireofAminoAcidsPrimaryStructure:AminoAcidsAreLinkedbyPeptideBondstoFormPolypeptideChainsSecondaryStructure:PolypeptideChainsCanFoldIntoRegularStructuresSuchastheAlphaHelix,theBetaSheet,andTurnsandLoopsTertiaryStructure:WaterSolubleProteinsFoldIntoCompactStructureswithNonpolarCoresQuaternaryStructure:PolypeptideChainsCanAssembleIntoMultisubunitStructuresTheAminoAcidSequenceofaProteinDeterminesItsThreeDimensionalStructureSummaryAppendix:AcidBaseConceptsProblemsSelectedReadingsExploringProteinsThePurificationofProteinsIsanEssentialFirstStepinUnderstandingTheirFunctionAminoAcidSequencesCanBeDeterminedbyAutomatedEdmanDegradationImmunologyProvidesImportantTechniqueswithWhichtoInvestigateProteinsPeptidesCanBeSynthesizedbyAutomatedSolidPhaseMethodsThreeDimensionalProteinStructureCanBeDeterminedbyNMRSpectroscopyandXRayCrystallographySummaryProblemsSelectedReadingsDNA,RNA,andtheFlowofGeneticInformationANucleicAcidConsistsofFourKindsofBasesLinkedtoaSugarPhosphateBackboneAPairofNucleicAcidChainswithComplementarySequencesCanFormaDoubleHelicalStructureDNAIsReplicatedbyPolymerasesthatTakeInstructionsfromTemplatesGeneExpressionIstheTransformationofDNAInformationIntoFunctionalMoleculesAminoAcidsAreEncodedbyGroupsofThreeBasesStartingfromaFixedPointMostEukaryoticGenesAreMosaicsofIntronsandExonsSummaryProblemsSelectedReadingsExploringGenesTheBasicToolsofGeneExplorationRecombinantDNATechnologyHasRevolutionizedAllAspectsofBiologyManipulatingtheGenesofEukaryotesNovelProteinsCanBeEngineeredbySiteSpecificMutagenesisSummaryProblemsSelectedReadingExploringEvolutionHomologsAreDescendedfromaCommonAncestorStatisticalAnalysisofSequenceAlignmentsCanDetectHomologyExaminationofThreeDimensionalStructureEnhancesOurUnderstandingofEvolutionaryRelationshipsEvolutionaryTreesCanBeConstructedontheBasisofSequenceInformationModernTechniquesMaketheExperimentalExplorationofEvolutionPossibleSummaryProblemsSelectedReadingsEnzymes:BasicConceptsandKineticsEnzymesArePowerfulandHighlySpecificCatalystsFreeEnergyIsaUsefulThermodynamicFunctionforUnderstandingEnzymesEnzymesAccelerateReactionsbyFacilitatingtheFormationoftheTransitionStateTheMichaelisMentenModelAccountsfortheKineticPropertiesofManyEnzymesEnzymesCanBeInhibitedbySpecificMoleculesVitaminsAreOftenPrecursorstoCoenzymesSummaryAppendix:VmaxandKMCanBeDeterminedbyDoubleReciprocalPlotsProblemsSelectedReadingsCatalyticStrategiesProteases:FacilitatingaDifficultReactionMakingaFastReactionFaster:CarbonicAnhydrasesRestrictionEnzymes:PerformingHighlySpecificDNACleavageReactionsNucleosideMonophosphateKinases:CatalyzingPhosphorylGroupExchangebetweenNucleotidesWithoutPromotingHydrolysisSummaryProblemsSelectedReadingsRegulatoryStrategies:EnzymesandHemoglobinAspartateTranscarbamoylaseIsAllostericallyInhibitedbytheEndProductofItsPathwayHemoglobinTransportsOxygenEfficientlybyBindingOxygenCooperativelyIsozymesProvideaMeansofRegulationSpecifictoDistinctTissuesandDevelopmentalStagesCovalentModificationIsaMeansofRegulatingEnzymeActivityManyEnzymesAreActivatedbySpecificProteolyticCleavageSummaryProblemsSelectedReadingsCarbohydratesMonosaccharidesAreAldehydesorKetoneswithMultipleHydroxylGroupsComplexCarbohydratesAreFormedbyLinkageofMonosaccharidesCarbohydratesCanBeAttachedtoProteinstoFormGlycoproteinsLectinsAreSpecificCarbohydrateBindingProteinsSummaryProblemsSelectedReadingsLipidsandCellMembranesManyCommonFeaturesUnderlietheDiversityofBiologicalMembranesFattyAcidsAreKeyConstituentsofLipidsThereAreThreeCommonTypesofMembraneLipidsPhospholipidsandGlycolipidsReadilyFormBimolecularSheetsinAqueousMediaProteinsCarryOutMostMembraneProcessesLipidsandManyMembraneProteinsDiffuseRapidlyinthePlaneoftheMembraneEukaryoticCellsContainCompartmentsBoundedbyInternalMembranesSummaryProblemsSelectedReadingsMembraneChannelsandPumpsTheTransportofMoleculesAcrossaMembraneMayBeActiveorPassiveAFamilyofMembraneProteinsUsesATPHydrolysistoPumpIonsAcrossMembranesMultidrugResistanceandCysticFibrosisHighlightaFamilyofMembraneProteinswithATPBindingCassetteDomainsSecondaryTransportersUseOneConcentrationGradienttoPowertheFormationofAnotherSpecificChannelsCanRapidlyTransportIonsAcrossMembranesGapJunctionsAllowIonsandSmallMoleculestoFlowbetweenCommunicatingCellsSummaryProblemsSelectedReadingsIITransducingandStoringEnergyMetabolism:BasicConceptsandDesignMetabolismIsComposedofManyCoupled,InterconnectingReactionsTheOxidationofCarbonFuelsIsanImportantSourceofCellularEnergyMetabolicPathwaysContainManyRecurringMotifsSummaryProblemsSelectedReadingsSignalTransductionPathways:AnIntroductiontoInformationMetabolismSevenTransmembraneHelixReceptorsChangeConformationinResponsetoLigandBindingandActivateGProteinsTheHydrolysisofPhosphatidylInositolBisphosphatebyPhospholipaseCGeneratesTwoMessengersCalciumIonIsaUbiquitousCytosolicMessengerSomeReceptorsDimerizeinResponsetoLigandBindingandSignalbyCrossphosphorylationDefectsinSignalingPathwaysCanLeadtoCancerandOtherDiseasesRecurringFeaturesofSignalTransductionPathwaysRevealEvolutionaryRelationshipsSummaryProblemsSelectedReadingsGlycolysisandGluconeogenesisGlycolysisIsanEnergyConversionPathwayinManyOrganismsTheGlycolyticPathwayIsTightlyControlledGlucoseCanBeSynthesizedfromNoncarbohydratePrecursorsGluconeogenesisandGlycolysisAreReciprocallyRegulatedSummaryProblemsSelectedReadingsTheCitricAcidCycleTheCitricAcidCycleOxidizesTwoCarbonUnitsEntrytotheCitricAcidCycleandMetabolismThroughItAreControlledTheCitricAcidCycleIsaSourceofBiosyntheticPrecursorsTheGlyoxylateCycleEnablesPlantsandBacteriatoGrowonAcetateSummaryProblemsSelectedReadingsOxidativePhosphorylationOxidativePhosphorylationinEukaryotesTakesPlaceinMitochondriaOxidativePhosphorylationDependsonElectronTransferTheRespiratoryChainConsistsofFourComplexes:ThreeProtonPumpsandaPhysicalLinktotheCitricAcidCycleAProtonGradientPowerstheSynthesisofATPManyShuttlesAllowMovementAcrosstheMitochondrialMembranesTheRegulationofCellularRespirationIsGovernedPrimarilybytheNeedforATPSummaryProblemsSelectedReadingsTheLightReactionsofPhotosynthesisPhotosynthesisTakesPlaceinChloroplastsLightAbsorptionbyChlorophyllInducesElectronTransferTwoPhotosystemsGenerateaProtonGradientandNADPHinOxygenicPhotosynthesisAProtonGradientAcrosstheThylakoidMembraneDrivesATPSynthesisAccessoryPigmentsFunnelEnergyIntoReactionCentersTheAbilitytoConvertLightIntoChemicalEnergyIsAncientSummaryProblemsSelectedReadingsTheCalvinCycleandthePentosePhosphatePathwayTheCalvinCycleSynthesizesHexosesfromCarbonDioxideandWaterTheActivityoftheCalvinCycleDependsonEnvironmentalConditionsthePentosePhosphatePathwayGeneratesNADPHandSynthesizesFiveCarbonSugarsTheMetabolismofGlucosePhosphatebythePentosePhosphatePathwayIsCoordinatedwithGlycolysisGlucosePhosphateDehydrogenasePlaysaKeyRoleinProtectionAgainstReactiveOxygenSpeciesSummaryProblemsSelectedReadingsGlycogenMetabolismGlycogenBreakdownRequirestheInterplayofSeveralEnzymesPhosphorylaseIsRegulatedbyAllostericInteractionsandReversiblePhosphorylationEpinephrineandGlucagonSignaltheNeedforGlycogenBreakdownGlycogenIsSynthesizedandDegradedbyDifferentPathwaysGlycogenBreakdownandSynthesisAreReciprocallyRegulatedSummaryProblemsSelectedReadingsFattyAcidMetabolismTriacylglycerolsAreHighlyConcentratedEnergyStoresTheUtilizationofFattyAcidsasFuelRequiresThreeStagesofProcessingCertainFattyAcidsRequireAdditionalStepsforDegradationFattyAcidsAreSynthesizedandDegradedbyDifferentPathwaysAcetylCoenzymeACarboxylasePlaysaKeyRoleinControllingFattyAcidMetabolismElongationandUnsaturationofFattyAcidsAreAccomplishedbyAccessoryEnzymeSystemsSummaryProblemsSelectedReadingsProteinTurnoverandAminoAcidCatabolismProteinsAreDegradedtoAminoAcidsProteinTurnoverIsTightlyRegulatedTheFirstStepinAminoAcidDegradationIstheRemovalofNitrogenAmmoniumIonIsConvertedIntoUreainMostTerrestrialVertebratesCarbonAtomsofDegradedAminoAcidsEmergeasMajorMetabolicIntermediatesInbornErrorsofMetabolismCanDisruptAminoAcidDegradationSummaryProblemsSelectedReadingsIIISynthesizingtheMoleculesofLifeTheBiosynthesisofAminoAcidsNitrogenFixation:MicroorganismsUseATPandaPowerfulReductanttoReduceAtmosphericNitrogentoAmmoniaAminoAcidsAreMadefromIntermediatesoftheCitricAcidCycleandOtherMajorPathwaysAminoAcidBiosynthesisIsRegulatedbyFeedbackInhibitionAminoAcidsArePrecursorsofManyBiomoleculesSummaryProblemsSelectedReadingsNucleotideBiosynthesisIndeNovoSynthesis,thePyrimidineRingIsAssembledfromBicarbonate,Aspartate,andGlutaminePurineBasesCanBeSynthesizeddeNovoorRecycledbySalvagePathwaysDeoxyribonucleotidesSynthesizedbytheReductionofRibonucleotidesThroughaRadicalMechanismKeyStepsinNucleotideBiosynthesisAreRegulatedbyFeedbackInhibitionNAD,FAD,andCoenzymeAAreFormedfromATPDisruptionsinNucleotideMetabolismCanCausePathologicalConditionsSummaryProblemsSelectedReadingsTheBiosynthesisofMembraneLipidsandSteroidsPhosphatidateIsaCommonIntermediateintheSynthesisofPhospholipidsandTriacylglycerolsCholesterolIsSynthesizedfromAcetylCoenzymeAinThreeStagesTheComplexRegulationofCholesterolBiosynthesisTakesPlaceatSeveralLevelsImportantDerivativesofCholesterolIncludeBileSaltsandSteroidHormonesSummaryProblemsSelectedReadingsDNAReplication,Recombination,andRepairDNACanAssumeaVarietyofStructuralFormsDNAPolymerasesRequireaTemplateandaPrimerDoubleStrandedDNACanWrapAroundItselftoFormSupercoiledStructuresDNAReplicationofBothStrandsProceedsRapidlyfromSpecificStartSitesDoubleStrandedDNAMoleculeswithSimilarSequencesSometimesRecombineMutationsInvolveChangesintheBaseSequenceofDNASummaryProblemsSelectedReadingsRNASynthesisandSplicingTranscriptionIsCatalyzedbyRNAPolymeraseEukaryoticTranscriptionandTranslationAreSeparatedinSpaceandTimeTheTranscriptionProductsofAllThreeEukaryoticPolymerasesAreProcessedTheDiscoveryofCatalyticRNAWasRevealinginRegardtoBothMechanismandEvolutionSummaryProblemsSelectedReadingsProteinSynthesisProteinSynthesisRequirestheTranslationofNucleotideSequencesIntoAminoAcidSequencesAminoacylTransferRNASynthetasesReadtheGeneticCodeARibosomeIsaRibonucleoproteinParticle(S)MadeofaSmall(S)andaLarge(S)SubunitProteinFactorsPlayKeyRolesinProteinSynthesisEukaryoticProteinSynthesisDiffersfromProkaryoticProteinSynthesisPrimarilyinTranslationInitiationSummaryProblemsSelectedReadingsTheIntegrationofMetabolismMetabolismConsistofHighlyInterconnectedPathwaysEachOrganHasaUniqueMetabolicProfileFoodIntakeandStarvationInduceMetabolicChangesFuelChoiceDuringExerciseIsDeterminedbyIntensityandDurationofActivityEthanolAltersEnergyMetabolismintheLiverSummaryProblemsSelectedReadingsTheControlofGeneExpressionProkaryoticDNABindingProteinsBindSpecificallytoRegulatorySitesinOperonsTheGreaterComplexityofEukaryoticGenomesRequiresElaborateMechanismsforGeneRegulationTranscriptionalActivationandRepressionAreMediatedbyProteinProteinInteractionsGeneExpressionCanBeControlledatPosttranscriptionalLevelsSummaryProblemsSelectedReadingsIVRespondingtoEnvironmentalChangesSensorySystemsAWideVarietyofOrganicCompoundsAreDetectedbyOlfactionTasteIsaCombinationofSensesthatFunctionbyDifferentMechanismsPhotoreceptorMoleculesintheEyeDetectVisibleLightHearingDependsontheSpeedyDetectionofMechanicalStimuliTouchIncludestheSensingofPressure,Temperature,andOtherFactorsSummaryProblemsSelectedReadingsTheImmuneSystemAntibodiesPossessDistinctAntigenBindingandEffectorUnitsTheImmunoglobulinFoldConsistsofaBetaSandwichFrameworkwithHypervariableLoopsAntibodiesBindSpecificMoleculesThroughTheirHypervariableLoopsDiversityIsGeneratedbyGeneRearrangementsMajorHistocompatibilityComplexProteinsPresentPeptideAntigensonCellSurfacesforRecognitionbyTCellReceptorsImmuneResponsesAgainstSelfAntigensAreSuppressedSummaryProblemsSelectedReadingsMolecularMotorsMostMolecularMotorProteinsAreMembersofthePLoopNTPaseSuperfamilyMyosinsMoveAlongActinFilamentsKinesinandDyneinMoveAlongMicrotubulesARotaryMotorDrivesBacterialMotionSummaryProblemsSelectedReadingsAppendixA:PhysicalConstantsandConversionofUnitsAppendixB:AcidityConstantsAppendixC:StandardBondLengthsGlossaryofCompoundsAnswerstoProblemsCommonAbbreviationsinBiochemistryDedicationTOOURTEACHERSANDOURSTUDENTSAbouttheauthorsJEREMYMBERGhasbeenProfessorandDirector(DepartmentChairperson)ofBiophysicsandBiophysicalChemistryatJohnsHopkinsUniversitySchoolofMedicinesinceHereceivedhisBSandMSdegreesinChemistryfromStanford(wherehelearnedXraycrystallographywithKeithHodgsonandLubertStryer)andhisPhDinChemistryfromHarvardwithRichardHolmHethencompletedapostdoctoralfellowshipwithCarlPaboProfessorBergisrecipientoftheAmericanChemicalSocietyAwardinPureChemistry(),theEliLillyAwardforFundamentalResearchinBiologicalChemistry(),theMarylandOutstandingYoungScientistoftheYear(),andtheHarrisonHoweAward()WhileatJohnsHopkins,hehasreceivedtheWBarryWoodTeachingAward(selectedbymedicalstudents),theGraduateStudentTeachingAward,andtheProfessor'sTeachingAwardforthePreclinicalSciencesHeiscoauthor,withStephenLippard,ofthetextPrinciplesofBioinorganicChemistryJOHNLTYMOCZKOistheTowsleyProfessorofBiologyatCarletonCollege,wherehehastaughtsinceHecurrentlyteachesBiochemistry,BiochemistryLaboratory,OncogenesandtheMolecularBiologyofCancer,andExerciseBiochemistryandcoteachesanintroductorycourse,BioenergeticsandGeneticsProfessorTymoczkoreceivedhisBAfromtheUniversityofChicagoinandhisPhDinBiochemistryfromtheUniversityofChicagowithShutsungLiaoattheBenMayInstituteforCancerResearchHefollowedthatwithapostdoctoralpositionwithHewsonSwiftoftheDepartmentofBiologyattheUniversityofChicagoProfessorTymoczko'sresearchhasfocusedonsteroidreceptors,ribonucleoproteinparticles,andproteolyticprocessingenzymesLUBERTSTRYERiscurrentlyWinzerProfessorintheSchoolofMedicineandProfessorofNeurobiologyatStanfordUniversity,wherehehasbeenonthefacultysinceHereceivedhisMDfromHarvardMedicalSchoolProfessorStryerhasreceivedmanyawardsforhisresearch,includingtheEliLillyAwardforFundamentalResearchinBiologicalChemistry()andtheDistinguishedInventorsAwardoftheIntellectualPropertyOwners'AssociationHewaselectedtotheNationalAcademyofSciencesinProfessorStryerwasformerlythePresidentandScientificDirectoroftheAffymaxResearchInstituteHeisafounderandamemberoftheScientificAdvisoryBoardofSenomyx,acompanythatisusingbiochemicalknowledgetodevelopnewandimprovedflavorandfragrancemoleculesforuseinconsumerproductsThepublicationofthefirsteditionofhistextBiochemistryintransformedtheteachingofbiochemistryPrefaceFormorethanyears,andthroughfoureditions,Stryer'sBiochemistryhaslaidoutthisbeautifulsubjectinanexceptionallyappealingandlucidmannerTheengagingwritingstyleandattractivedesignhavemadethetextapleasureforourstudentstoreadandstudythroughoutouryearsofteachingThus,weweredelightedtobegiventheopportunitytoparticipateintherevisionofthisbookThetaskhasbeenexcitingandsomewhatdaunting,doublysobecauseofthedramaticchangesthataretransformingthefieldofbiochemistryaswemoveintothetwentyfirstcenturyBiochemistryisrapidlyprogressingfromascienceperformedalmostentirelyatthelaboratorybenchtoonethatmaybeexploredthroughcomputersTherecentlydevelopedabilitytodetermineentiregenomicsequenceshasprovidedthedataneededtoaccomplishmassivecomparisonsofderivedproteinsequences,theresultsofwhichmaybeusedtoformulateandtesthypothesesaboutbiochemicalfunctionThepowerofthesenewmethodsisexplainedbytheimpactofevolution:manymoleculesandbiochemicalpathwayshavebeengeneratedbyduplicatingandmodifyingexistingonesOurchallengeinwritingthefifth

用户评价(0)

关闭

新课改视野下建构高中语文教学实验成果报告(32KB)

抱歉,积分不足下载失败,请稍后再试!

提示

试读已结束,如需要继续阅读或者下载,敬请购买!

文档小程序码

使用微信“扫一扫”扫码寻找文档

1

打开微信

2

扫描小程序码

3

发布寻找信息

4

等待寻找结果

我知道了
评分:

/49

Biochemistry 5th ed

仅供在线阅读

VIP

在线
客服

免费
邮箱

爱问共享资料服务号

扫描关注领取更多福利