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首页 饲用酶制剂在现代饲料

饲用酶制剂在现代饲料.ppt

饲用酶制剂在现代饲料

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2019-06-15 0人阅读 举报 0 0 暂无简介

简介:本文档为《饲用酶制剂在现代饲料ppt》,可适用于综合领域

保来康XingyeBiotechLtd饲用酶制剂在现代饲料养殖业中的作用于锋博士东莞泛亚太生物科技有限公司保来康XingyeBiotechLtd面对禁用抗生素促生长剂的挑战!于锋博士爱保农(东莞)生物科技有限公司保来康XingyeBiotechLtd欧洲禁用促生长剂Avoparcin()Spiramycin()Zincbacitracin(July)Virginiamycin(July)Tylosin(July)Olaquindox(Sept)保来康XingyeBiotechLtd抗生素的作用抗生素杀死目标细菌(包括病原菌)减少对饲料养分的竞争允许有益菌生长防止菌落在肠壁上着落、繁殖。改善吸收肠道功能减少毒素保来康XingyeBiotechLtd为什么?增加抗药性对人健康的危害公众的观念媒体保来康XingyeBiotechLtd不用抗生素促生长剂意味着什么增加亚临床临床疾病料肉比下降单位肉品成本增加死淘率增高鸡群变异性升高利润下降可销售肉品数量下降达到上市体重的数量减少垫料潮湿ThisflowchartistoreenforcethepotentialproblemswhicharegoingtobeencounteredwhenAGPsareremovedfrombroilerdiets保来康XingyeBiotechLtd对我国有何影响?保来康XingyeBiotechLtd可能的选择酶和甜菜碱有机酸酸化剂喷在饲料上控制霉菌及细菌的污染抑生素清除肠道内不良细菌消化酵母促进内源酶的分泌以及乳酸量必需脂肪酸促进酶的分泌并调整肠道微生物环境(例如oregano)需要高剂量才能达到灭菌效果保来康XingyeBiotechLtd可能的选择硫酸铜复合效应:灭菌,酸刺激或者酶的分泌,垫料情况(因素!)影响家禽的生长速度CCK抗体在动物进食后CCK短链多肽(消化抑制素)释放并通过肠道细胞进入血液抗体给母鸡注射通过鸡蛋的蛋黄产生抗体肉鸡生长性能提高(wtgnFCR)不耐热抗球虫剂离子载体添加抑菌活性(例如莫能菌,盐霉素)特别是抗沙门氏菌和芽孢杆菌保来康XingyeBiotechLtd可能的选择甘露低聚糖例如生物免疫促进剂(附着在肠道连接点使机体产生反应或者锁住微生物连接点)证明有促进生长的作用但也许只限于部分具有挑战性的动物。能量的消耗需要免疫应答吗?维生素D(H)未得到FDA认可便宜钙吸收=>产蛋鸡和蛋壳质量硫酸氢钠通过减少水分吸收来改善垫料湿度不含氯协同离子载体活性=>促进生长效果维持高温时血液中盐水平便宜保来康XingyeBiotechLtd东莞泛亚太生物科技有限公司能为您提供什么保来康XingyeBiotechLtd爱维生Ò保安生保来康XingyeBiotechLtd在无抗生素促生长剂饲料中的角色AlthoughsomepartsofthispresentationwouldalsoapplytononviscousdietswiththeremovalofAGPs,themainfocushasbeenviscousbaseddietsforbroilersMoredatafornonviscousdietsshouldbeavailableinthefuture保来康XingyeBiotechLtd撤除抗生素对饲料转化率的影响Reference:ElwingerandTeglof,Hocketal,MoranandMcGinnis,VranjesandWenk,损失ThisfigurecomparestheimpactofAGPsandenzymesinheadtoheadtrialsThesetrialswerewheatbaseddietsusingenzymesTheenzymesusedinthesetrialsarenotspecificforFinnfeeds(notallAvizyme)butarevalidtoshowtheeffectacrossenzymeapplications保来康XingyeBiotechLtd抗生素促生长剂与爱保酶抗生素促生长剂改善饲料效率约*(有酶制剂)直接杀死肠道微生物爱保酶改善饲料效率约(抗生素)**改变肠道环境无直接抗菌效果利于有益菌生长:由于降价非淀粉多糖而减少回肠微生物和促进盲肠微生物发酵酶制剂的作用机理不同于抗生素促生长剂References:*ElwingerTeglof,Hocketal,MoranMcGinnis,VranjesWenk,**FinnfeedsInternalDataEnzymesarenotareplacementforantibioticgrowthpromotants(AGPs)However,withtheremovalofAGPs,enzymesmaybeatooltominimisethenegativeeffectofAGPremovalInaddition,beawarethatproducersmayalsobeevaluatingotherapproachestominimisethenegativeeffectofAGPremovalManyoftheseapproachesmayworkwellincombinationwithenzymesReduceproteinandincreasedietaryparticlesizeResultincreasesgizzardactivitywhichmorefinelygrindsthefeedandreducesnitrogenavailableforilealandcaecalpathogensAcidifiersUseofwholewheatincreasesgizzardactivityUseofhigherqualityrawmaterialsreducesindigestiblefractionreachingileumandcaecumregionBETAINEMaintainsosmoticbalancewhichincreasesintestinalintegrityandmaintainscellularwaterbalance,particularlybeneficialduringperiodsofdiseasestress保来康XingyeBiotechLtd爱保酶在无抗生素饲料中的作用爱保酶降低肠道食糜粘稠度提高利润ThekeymodesofactionforAvizymeinviscousdietsinclude:IntestinalviscosityreductionIncreasednutrientdigestibilityAlteredintestinalcarbohydrateprofileTheimpactwhenviscosityishigh(poorsamplesofwheat)andornutrientsarepoorlydigested(poorlydigestedlowviscousgrains)isbiggerwiththeremovalofAGPsGreateramountsofrapidlydigestiblesubstratereachtheendofthesmallintestine,and,asaresult,bacterialpopulationsbloomIncreasedbacterialpopulationschallengethebirdonmanyfronts:CompetitionfornutrientsInteractionwithdamageoftheintestineIncreasedincidenceofdiseaseIncreasesnutrientrequirementsformaintenanceAlltheabovereducethegrowthrateandfeedefficiencyofthebirdEffectiveexogenousenzymeswillremovemuchofthesubstrateLesssubstratereachestheendofthesmallintestine,resultinginreducednutrientavailabilityfortheorganismsConsequentlyreducednutrientavailabilitydecreasesbacterialpopulationsinthegut,allowingthebirdtoadapttothedietandperformmoreeffectivelyIeFEEDTHEBIRD,STARVETHEMICROFLORA!!保来康XingyeBiotechLtd肠道微生物影响肉鸡生长速度及日粮能量平均体重表观代谢能无菌正常平均体重表观代谢能(Murumatsuetal,)保来康XingyeBiotechLtd理想的消化率减少供给回肠微生物的养分较少的微生物吸收的养分十二指肠空肠回肠保来康XingyeBiotechLtd消化缓慢增加供给回肠微生物的养分微生物增多吸收的养分减少十二指肠空肠回肠保来康XingyeBiotechLtd粘稠度影响肠道微生物数量Increasingtheinclusionofhighviscouscereals(egrye)inthedietincreasesdigestaviscosityVariationsindigestaviscosityinfluencethemicrobialprofileinthecaecumEnterococciaregenerallyconsideredtobedetrimentaltobirdperformance,andinthistrial,increasewithincreasingviscosityLactobacilli,whicharegenerallyconsideredasfavourable,reduceasviscosityincreases保来康XingyeBiotechLtd爱保酶降低肠道食糜粘度Reference:TechnicalReports,FinnSearchViscosityslowsdowndigestion,resultinginpoornutrientabsorption(iefat,protein),whichleavesmoresubstrate(especiallycarbohydrates)forbacterialgrowthIncreasedbacterialpopulationschallengethebirdonmanyfronts:CompetitionfornutrientsInteractionwithdamageoftheintestineIncreasedincidenceofdiseaseIncreasesnutrientrequirementsformaintenanceAlltheabovereducethegrowthrateofthebirdManytrialshaveshownthatAvizyme,andreduceviscosityinbarley,wheatbarleyandwheatbasedpoultrydiets保来康XingyeBiotechLtd爱保酶提高消化率和生长性能Reference:UKSAC,Auchincruive,UKThisslideindicatestheeffectofenzymewhichsignificantlyincreasenutrientdigestibilityIntermsofthispresentation,thiscanberepresentedasremovingsubstratefromtheileumwhichwouldotherwisehavebeenavailabletosustainmicrobialpopulationsinthisportionofthesmallintestineFurtherTechnicalReportssupportingAvizymeimprovingnutrientdigestibilityinclude:UKAUSAUSGERForAvizymeSPASPAUS保来康XingyeBiotechLtd爱保酶提高消化率和生长性能Reference:CTC,Finland,ColiformsLacticAcidBacteriaEnterococci总数对照爱保酶菌落数量(x)Avizymeimprovesnutrientdigestibility,thereforeremovingsubstratefromtheileumwhichwouldotherwisehavebeenavailabletosustainmicrobialpopulationsinthisportionofthesmallintestine保来康XingyeBiotechLtd爱保酶改变达到肠道后端碳水化合物的成分Reference:ApajalahtiBedford,ThenextthreeslidesexplaintheeffectofalteringthecarbohydrateprofileinpoultrydietsThesubsequentbenefitsofthismaybemorerelevantinAGPfreedietsTrialshaveshownthatAvizymeincreasestheconcentrationofshortchaincarbohydrates(xylooligomers)inthesmallintestineTheseshortchainxylooligomersareinterestingastheycanpotentiallyfuelgrowthofbeneficialbacteria保来康XingyeBiotechLtd爱保酶改变达到肠道后端碳水化合物的成分Reference:ApajalahtiBedford,WorkinFinlandhasshownthatAvizymereducesthesizeoftheviscouspolymers(longchaincarbohydrates)tosmallersugars,whicharenotusedorabsorbedbythebirdbutwhichcanenterthecaecawheretheyarefermentedbythemicrofloraInatrialatCTC,additionofAvizymeincreasedcaecalactivity,asmeasuredbycaecalVFAproductionTheenzymeiseffectivelyprovidingasubstrateforbacterialfermentationwhichotherwisemaynothavebeenpresentInaddition,thetypeoffermentationchanges,withanincreaseinaceticandpropionicacidsandareductioninbutyricacid(whichaltersthepHprofileofthecaeca)Twofactorsneedconsiderationhere:TheVFA’smaysupplyenergytothebirdhowmuchTheVFA’smayaffectpopulationsofmanypathogensandzoonoticorganismssuchasSalmonella保来康XingyeBiotechLtd爱保酶改变达到肠道后端碳水化合物的成分Reference:ApajalahtiBedford,Importantnote:Todate,theassumptionhasbeenthatfeedingenzymeswouldreducetheamountofbiomassinthesmallintestineandcaecalregionsHowever,newdataindicatesthatthisisnotthecaseinthecaecalregionNotonlyisthetotalcaecalpopulationincreasedinbirdsfedenzymesupplementeddiets,butthespeciesdominancechangesInthisslide,eachgenusisdisplayedasapercentageoftotalDNApresentinthecaeca(Althoughthisshouldadduptosomeminorspecieswereleftoff,therefore,totalwillbeonlyapproximately)Avizymereducesthesizeoftheviscouspolymer(viscousNSPs)tosmallsugars(xylooligomers)ThesesmallxylooligomersactasasubstrateforBifidobacter,thereforeincreasingthesmallxylooligomercontentinthecaeca,whichradicallyincreasesBifidobacterandBacteroides(grampositivebacteria)Bifidobacter,amongstotherspecies,produceacidswhichreducethenumberofenterobacteria(includesSalmonella),ClostridiaandCampylobacterClearlyenzymeadditioncouldmarkedlyshiftmicrobialpopulationsinthecaecainaverydifferentmannertotheeffectithasintheileum(ProductinthistrialwasAvizyme)保来康XingyeBiotechLtd抗生素加强酶制剂的效应Reference:ElwingerandTeglof,Hocketal,MoranandMcGinnis,VranjesandWenk,Asshowninthepreviousslide“TheeffectofremovingantibioticgrowthpromotersonFCR”,theaboveslidesummarisestheeffectsofenzymesandantibioticsonbroilerFCRInthesetrials,theaverageeffectofenzymewastoimproveperformanceby,andincombinationwithAGPs(preEUban),ledtoanadditionalimprovementPointtoconsider:Previously,enzymeshavebeentestedbyfeedmanufacturersundercommercialconditionsinthepresenceofAGPsWiththeremovalofAGPs,theresponsetoenzymeswillbelarger,relativetonoenzymesupplementationItshouldbeeasiertodetectperformancedifferenceswhenfeedingenzymesespeciallybetweendifferentcerealqualities(Iehighandlowviscouscereals)Inaddition,moredistinctdifferenceswillbeapparentbetweenenzymeproductsunderthesecircumstancesTheconsequenceofunderdosingwillbecomemorecriticalduetothelargerresponsetoeachadditionalgofenzymereferenceslide“Enzymeefficacyanddoseismorecritical”保来康XingyeBiotechLtd停用促生长剂的国家采用的措施降低蛋白质增加日粮颗粒大小-增强肌胃活动使日粮研磨的更碎更易消化从而减少能被回肠和盲肠微生物利用的氮的量酸化剂-杀死病原菌使用整粒小麦-增加肌胃活动使用好原料-减少不可消化养分酶制剂-继续在使用但在微生物控制方面的益处赏缺乏很好的认识甜菜碱-维护渗透压和水平衡增强肠道细胞完整性。在患肠道疾病时尤为有益ThisflowchartistoreenforcethepotentialproblemswhicharegoingtobeencounteredwhenAGPsareremovedfrombroilerdietsAlthoughsomepartsofthispresentationwouldalsoapplytononviscousdietswiththeremovalofAGPs,themainfocushasbeenviscousbaseddietsforbroilersMoredatafornonviscousdietsshouldbeavailableinthefutureThisfigurecomparestheimpactofAGPsandenzymesinheadtoheadtrialsThesetrialswerewheatbaseddietsusingenzymesTheenzymesusedinthesetrialsarenotspecificforFinnfeeds(notallAvizyme)butarevalidtoshowtheeffectacrossenzymeapplicationsEnzymesarenotareplacementforantibioticgrowthpromotants(AGPs)However,withtheremovalofAGPs,enzymesmaybeatooltominimisethenegativeeffectofAGPremovalInaddition,beawarethatproducersmayalsobeevaluatingotherapproachestominimisethenegativeeffectofAGPremovalManyoftheseapproachesmayworkwellincombinationwithenzymesReduceproteinandincreasedietaryparticlesizeResultincreasesgizzardactivitywhichmorefinelygrindsthefeedandreducesnitrogenavailableforilealandcaecalpathogensAcidifiersUseofwholewheatincreasesgizzardactivityUseofhigherqualityrawmaterialsreducesindigestiblefractionreachingileumandcaecumregionBETAINEMaintainsosmoticbalancewhichincreasesintestinalintegrityandmaintainscellularwaterbalance,particularlybeneficialduringperiodsofdiseasestressThekeymodesofactionforAvizymeinviscousdietsinclude:IntestinalviscosityreductionIncreasednutrientdigestibilityAlteredintestinalcarbohydrateprofileTheimpactwhenviscosityishigh(poorsamplesofwheat)andornutrientsarepoorlydigested(poorlydigestedlowviscousgrains)isbiggerwiththeremovalofAGPsGreateramountsofrapidlydigestiblesubstratereachtheendofthesmallintestine,and,asaresult,bacterialpopulationsbloomIncreasedbacterialpopulationschallengethebirdonmanyfronts:CompetitionfornutrientsInteractionwithdamageoftheintestineIncreasedincidenceofdiseaseIncreasesnutrientrequirementsformaintenanceAlltheabovereducethegrowthrateandfeedefficiencyofthebirdEffectiveexogenousenzymeswillremovemuchofthesubstrateLesssubstratereachestheendofthesmallintestine,resultinginreducednutrientavailabilityfortheorganismsConsequentlyreducednutrientavailabilitydecreasesbacterialpopulationsinthegut,allowingthebirdtoadapttothedietandperformmoreeffectivelyIeFEEDTHEBIRD,STARVETHEMICROFLORA!!Increasingtheinclusionofhighviscouscereals(egrye)inthedietincreasesdigestaviscosityVariationsindigestaviscosityinfluencethemicrobialprofileinthecaecumEnterococciaregenerallyconsideredtobedetrimentaltobirdperformance,andinthistrial,increasewithincreasingviscosityLactobacilli,whicharegenerallyconsideredasfavourable,reduceasviscosityincreasesViscosityslowsdowndigestion,resultinginpoornutrientabsorption(iefat,protein),whichleavesmoresubstrate(especiallycarbohydrates)forbacterialgrowthIncreasedbacterialpopulationschallengethebirdonmanyfronts:CompetitionfornutrientsInteractionwithdamageoftheintestineIncreasedincidenceofdiseaseIncreasesnutrientrequirementsformaintenanceAlltheabovereducethegrowthrateofthebirdManytrialshaveshownthatAvizyme,andreduceviscosityinbarley,wheatbarleyandwheatbasedpoultrydietsThisslideindicatestheeffectofenzymewhichsignificantlyincreasenutrientdigestibilityIntermsofthispresentation,thiscanberepresentedasremovingsubstratefromtheileumwhichwouldotherwisehavebeenavailabletosustainmicrobialpopulationsinthisportionofthesmallintestineFurtherTechnicalReportssupportingAvizymeimprovingnutrientdigestibilityinclude:UKAUSAUSGERForAvizymeSPASPAUSAvizymeimprovesnutrientdigestibility,thereforeremovingsubstratefromtheileumwhichwouldotherwisehavebeenavailabletosustainmicrobialpopulationsinthisportionofthesmallintestineThenextthreeslidesexplaintheeffectofalteringthecarbohydrateprofileinpoultrydietsThesubsequentbenefitsofthismaybemorerelevantinAGPfreedietsTrialshaveshownthatAvizymeincreasestheconcentrationofshortchaincarbohydrates(xylooligomers)inthesmallintestineTheseshortchainxylooligomersareinterestingastheycanpotentiallyfuelgrowthofbeneficialbacteriaWorkinFinlandhasshownthatAvizymereducesthesizeoftheviscouspolymers(longchaincarbohydrates)tosmallersugars,whicharenotusedorabsorbedbythebirdbutwhichcanenterthecaecawheretheyarefermentedbythemicrofloraInatrialatCTC,additionofAvizymeincreasedcaecalactivity,asmeasuredbycaecalVFAproductionTheenzymeiseffectivelyprovidingasubstrateforbacterialfermentationwhichotherwisemaynothavebeenpresentInaddition,thetypeoffermentationchanges,withanincreaseinaceticandpropionicacidsandareductioninbutyricacid(whichaltersthepHprofileofthecaeca)Twofactorsneedconsiderationhere:TheVFA’smaysupplyenergytothebirdhowmuchTheVFA’smayaffectpopulationsofmanypathogensandzoonoticorganismssuchasSalmonellaImportantnote:Todate,theassumptionhasbeenthatfeedingenzymeswouldreducetheamountofbiomassinthesmallintestineandcaecalregionsHowever,newdataindicatesthatthisisnotthecaseinthecaecalregionNotonlyisthetotalcaecalpopulationincreasedinbirdsfedenzymesupplementeddiets,butthespeciesdominancechangesInthisslide,eachgenusisdisplayedasapercentageoftotalDNApresentinthecaeca(Althoughthisshouldadduptosomeminorspecieswereleftoff,therefore,totalwillbeonlyapproximately)Avizymereducesthesizeoftheviscouspolymer(viscousNSPs)tosmallsugars(xylooligomers)ThesesmallxylooligomersactasasubstrateforBifidobacter,thereforeincreasingthesmallxylooligomercontentinthecaeca,whichradicallyincreasesBifidobacterandBacteroides(grampositivebacteria)Bifidobacter,amongstotherspecies,produceacidswhichreducethenumberofenterobacteria(includesSalmonella),ClostridiaandCampylobacterClearlyenzymeadditioncouldmarkedlyshiftmicrobialpopulationsinthecaecainaverydifferentmannertotheeffectithasintheileum(ProductinthistrialwasAvizyme)Asshowninthepreviousslide“TheeffectofremovingantibioticgrowthpromotersonFCR”,theaboveslidesummarisestheeffectsofenzymesandantibioticsonbroilerFCRInthesetrials,theaverageeffectofenzymewastoimproveperformanceby,andincombinationwithAGPs(preEUban),ledtoanadditionalimprovementPointtoconsider:Previously,enzymeshavebeentestedbyfeedmanufacturersundercommercialconditionsinthepresenceofAGPsWiththeremovalofAGPs,theresponsetoenzymeswillbelarger,relativetonoenzymesupplementationItshouldbeeasiertodetectperformancedifferenceswhenfeedingenzymesespeciallybetweendifferentcerealqualities(Iehighandlowviscouscereals)Inaddition,moredistinctdifferenceswillbeapparentbetweenenzymeproductsunderthesecircumstancesTheconsequenceofunderdosingwillbecomemorecriticalduetothelargerresponsetoeachadditionalgofenzymereferenceslide“Enzymeefficacyanddoseismorecritical”

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饲用酶制剂在现代饲料

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