胶质限制前体细胞及其衍生的星形胶质细胞：在脊髓损伤中的特性和治疗潜力

SICENCE新闻发布作者: Kazuo Hayakawa稿号:NRR-D-15-00639 胶质限制前体细胞及其衍生的星形胶质细胞:在脊髓损伤中的特性和治疗潜力 星形胶质细胞是中枢神经系统中最丰富的细胞类型,主要负责支持中枢神经系统功能的发育和稳定。并且星形胶质细胞也参与到各种神经疾病的损伤过程,它们在损伤过程中可以被活化也可能功能失调。鉴于这种不同效果,如今重要的是不仅要定义它们的表型和功能性质,还要识别其分子机制并开发能够支持性星形胶质细胞亚型的制备方法,尤其是当这些细胞在中枢神经系统中被用作有益移植时。这些支持性星形胶质细胞在中枢神经系统损伤后可以带来众多有益效果:促进宿主轴突再生、限制炎症反应,减弱损伤部位的抑制微环境,创造轴突生长和突触连接的有益环境。重要的是,其可以恢复脊髓损伤后的功能连接,并集中促进宿主轴突的再生,和利用移植来源神经元进行神经元连续传送,这都是通过使用支持性星形胶质细胞的促进策略。美国德雷克塞尔大学医学院Itzhak Fischer教授实验室在发表于《中国神经再生研究(英文版)》2016年4月4期的观点文章的目的是总结有关胶质限制前体细胞和派生星形胶质细胞的属性,并讨论这些发现如何能够转化为促进连通性和恢复脊髓损伤的治疗策略。 Article: "Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury" by Kazuo Hayakawa1, 2, Christopher Haas1, Itzhak Fischer1(1 Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA; 2 Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan) Hayakawa K, Haas C, Fischer I (2016) Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury. Neural Regen Res 11(4):529-533. 欲获更多资讯:请与《中国神经再生研究(英文版)》杂志国际发展部联络;联络电话:+86138********,或用电子邮件联络:eic@nrren.org。文章全文请见: SICENCE新闻发布作者: Kazuo Hayakawa稿号:NRR-D-15-00639 胶质限制前体细胞及其衍生的星形胶质细胞:在脊髓损伤中的特性和治疗潜力 星形胶质细胞是中枢神经系统中最丰富的细胞类型,主要负责支持中枢神经系统功能的发育和稳定。并且星形胶质细胞也参与到各种神经疾病的损伤过程,它们在损伤过程中可以被活化也可能功能失调。鉴于这种不同效果,如今重要的是不仅要定义它们的表型和功能性质,还要识别其分子机制并开发能够支持性星形胶质细胞亚型的制备方法,尤其是当这些细胞在中枢神经系统中被用作有益移植时。这些支持性星形胶质细胞在中枢神经系统损伤后可以带来众多有益效果:促进宿主轴突再生、限制炎症反应,减弱损伤部位的抑制微环境,创造轴突生长和突触连接的有益环境。重要的是,其可以恢复脊髓损伤后的功能连接,并集中促进宿主轴突的再生,和利用移植来源神经元进行神经元连续传送,这都是通过使用支持性星形胶质细胞的促进策略。文章的目的是总结有关胶质限制前体细胞和派生星形胶质细胞的属性,并讨论这些发现如何能够转化为促进连通性和恢复脊髓损伤的治疗策略。 Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury In the aftermath of spinal cord injury, glial restricted precursors (GRPs) and immature astrocytes offer the potential to modulate the inflammatory environment of the injured spinal cord and promote host axon regeneration. Nevertheless clinical application of cellular therapy for the repair of spinal cord injury requires strict quality-assured protocols for large-scale production and preservation that necessitates long-term in vitro expansion. Importantly, such processes have the potential to alter the phenotypic and functional properties and thus therapeutic potential of these cells. Furthermore, clinical use of cellular therapies may be limited by the inflammatory microenvironment of the injured spinal cord, altering the phenotypic and functional properties of grafted cells. This report simulates the process of large-scale GRP production and demonstrates the permissive properties of GRP following long-term in vitro culture. Furthermore, we defined the phenotypic and functional properties of GRP in the presence of inflammatory factors, and call attention to the importance of the microenvironment of grafted cells, underscoring the importance of modulating the environment of the injured spinal cord. 基金资助:这项工作由美国国立卫生研究院PO1 NS055976,克雷格·H·尼尔森基金会支持。