LUNG CT REGISTRATION COMBINING INTENSITY, CURVES AND SURFACES
Vladlena Gorbunova 1 ∗, Stanley Durrleman2,3, Pechin Lo1, Xavier Pennec2, Marleen de Bruijne1,4
1Department of Computer Science, Univercity of Copenhagen, Denmark
2INRIA Sophia Antipolis, Asclepios, France
3Centre de Mathematique et Leurs Application, ENS Cachan, France
4Biomedical Imaging Group Rotterdam, Erasmus MC, Rotterdam, the Netherlands
ABSTRACT
In this paper we propose a registration method that com-
bines intensity information with geometrical information in
the form of curves and surfaces derived from lung CT im-
ages. Vessel tree centerlines and lung surfaces were extracted
from segmented structures. First, a current-based registration
was applied to align the pulmonary vessel tree and the lung
surfaces. Subsequently, the resulting deformation field was
used to constrain an intensity-based registration method. We
applied the combined registration on a set of image pairs, ex-
tracted at the end exhale and the end inhale phases of 4D-
CT scans. The proposed combined registration was com-
pared to intensity-based registration, using a set of manually
selected landmarks. The proposed registration decreases the
mean and the standard deviation of the target registration er-
rors for all 5 cases to on average 1.47±1.05 mm, compared to
the intensity-based registration without constraint 1.74±1.31
mm.
Index Terms— Image registration, BSplines, currents,
lung CT.
1. INTRODUCTION
The ultimate goal of any registration algorithm is to es-
tablish dense point-to-point correspondence between two im-
ages. Generally, registration of lung CT images is a difficult
problem due to the possible large variation between the scans.
Scans of the same patient taken at maximum inspiration, can
have more than 0.5 liter difference in lung volume. The reg-
istration of end exhale and end inhale phases of 4D-CT lung
images is an even more difficult problem due to the large and
non-uniform deformations during the breathing cycle [1].
Image registration methods can be divided into two
groups of methods: intensity-based and feature-based. A
feature-based method establishes deformations based on low-
dimensional features, derived from the original images, while
∗ This work is financially supported by the Danish Council for Strategic
Research under the Programme Commission for Nanoscience and Technol-
ogy, Biotechnology and IT (NABIIT), the Netherlands Organization for Sci-
entific Research (NWO), and AstraZeneca, Lund, Sweden. Authors would
like to thank Jon Sporring, Copenhagen University, Department of Computer
Science, eScience Center, for fruitful discussions.
intensity-based method considers intensity information over
complete image. The state-of-the art registration methods
for lung CT images are mainly intensity-based approaches
[2] because the feature-based methods generally produce less
accurate results [3].
Recently, Li et al. [4] developed an image registration al-
gorithm where the intensity-based registration was improved
with the subsequent bio-mechanical simulation of lung in-
flation. Results showed an improvement in both accuracy
of registration and physical plausibility of the deformation
field for the combined approach. We previously developed a
feature-based algorithm for registering lung CT images and
compared it to intensity-based registration [5]. The overall
accuracy of the feature-based algorithm was slightly worse
than that of the intensity-based algorithm, but in 35 % of
landmarks the feature-based registration outperformed the
intensity-based method. The results inspired us to investi-
gated how the intensity-based registration can be improved
with the results of the feature-based registration.
The direct combination of two completely different reg-
istration methods is usually not possible, particularly if the
underlying deformation models are different. For exam-
ple, in parametric non-rigid registration, deformation fields
are commonly modeled with b-spline functions, while in
non-parametric methods deformation fields are usually mod-
eled using partial differential equations. Furthermore, in
landmark-based registration deformations are modeled by
thin-plate splines or radial basis functions. We propose a
solution to this problem and instead of combining the models
we constrain the final results of the registration - the defor-
mation fields - in a least square sense. While feature-based
methods can more accurately estimate deformation fields of
the features, the intensity-based method can benefit from its
results and improve the overall accuracy of alignment further
away from the features. The study [6] presents a similar
solution to this problem, the registration algorithm which in-
tegrates intensity-based and feature-based methods. The cost
function incorporates difference in intensities and difference
in the distances to the annotated surfaces.
In this paper, we combine the previously developed
340978-1-4244-4126-6/10/$25.00 ©2010 IEEE ISBI 2010
feature-based algorithm with the B-spline intensity regis-
tration algorithm and evaluate performance on 5 image pairs
with manually annotated landmarks.
2. METHOD
The section briefly recalls the feature-based registration
method and the non-rigid intensity-based registration method.
We propose to combine both approaches as it is described in
Section 2.3.
2.1. Current-based registration
In our previous work, we developed a feature-based regis-
tration, where the vessel centerlines and lung surfaces, were
used to establish correspondence between lung CT scans [5].
Both vessel centerlines and lung surfaces were represented
in a framework of currents and aligned using the metric on
currents. The current μ for a vessel centerline C is repre-
sented by tangential vectors attached to the centerline points
and for a triangulated surface S it is represented by normal
directions attached to the centers of each face. Norm of a
current μ(C), μ(S) is defined via a path integral, in case of
curves, or flux integral for surfaces [7]. The cost function
between anatomical lung structures in a fixed image Cf , Sf
and a moving image Cm, Sm is defined as a weighted sum of
the similarity measures between currents for the vessel cen-
terlines Cf , Cm, the similarity between currents for surfaces
the Sf , Sm, and a regularization term:
E(Cf , Sf ;Cm, Sm) = γC ||μ(Cf )− μ(φ(Cm))||2W
+ γS ||μ(Sf )− μ(φ(Sm))||2W + γφ
∫ 1
0
||vt||2V dt. (1)
Diffeomorphic transformation φ of curves and surfaces was
modeled in the framework of large deformation diffeomor-
phic matching [7], where deformation of each feature point
is defined by a velocity vector field vt = φ′t. The smooth
velocity field vt is described via a Gaussian kernel with stan-
dard deviation σV , where σV determines the typical scale of
the deformations [8]. The smoothness of the currents is deter-
mined by the parameter σW [8].
2.2. Intensity-based registration via BSplines
In this paper we used a multi-resolution image registra-
tion framework similar to the framework developed in [9].
First, lung regions were extracted from the CT images and
the background value was set to 0 HU. Images were aligned
with affine transform TA. Subsequently, a series of 3 B-Spline
transforms T i=1..3B−Spline with decreasing grid size was applied
to the affinely registered images. Thus, the final deforma-
tion is a composition of the affine transform and 3 levels of
B-Spline transforms:
Tfinal(x) = T 3B−Spline ◦ ... ◦ T 1B−Spline ◦ TA(x), (2)
where x is a point in the moving image. We use the sum
of squared intensity differences as the similarity measure be-
tween the images,
Eint(If , Im;T ) =
1
|Ω| ||If (x)− Im(T (x))||
2
L2 , (3)
where If is the fixed image, Im is the moving image andΩ the
region of intersection. Each level was optimized separately
using a stochastic gradient descent optimizer.
2.3. Combined registration
We propose to constrain the intensity-based registration
of Section 2.2 with the deformation field obtained from the
current-based registration of Section 2.1. We constrain b-
spline deformation field �Dbsp to match the given final defor-
mation field �Dcurr by minimizing the L2 distance between
the deformations. Since the current-based registration uses
anatomical lung features to establish the correspondence, the
deformation field in locations close to the extracted features
is expected to be more reliable than further away from the
features. Thus, we propose to incorporate a spatially vary-
ing weight w(x) ∈ [0; 1], x ∈ Ω into the constrain between
the deformation fields, which defines the trade off between
matching intensity and deformations for every voxel x. The
combined cost function then consists of the sum of squared
intensity differences similarity function and constraint on the
deformation field:
E(If , Im;T ) = Eint + γEdef =
1
|Ω|
∫
Ω
(1− w(x)) ||If (x)− Im(T (x))||2dx +
λ
|Ω|
∫
Ω
w(x)|| �Dbsp(x)− �Dcur(x)||2dx, (4)
where the coefficient λ compensates for the difference in units
of the two terms. The deformation field �Dbsp(x) is a vector
field defined as �Dbsp(x) = T (x) − x. Using vector notation,
the gradient of the cost function (4) can be computed explic-
itly:
DaE(If , Im;T ) =
− 2|Ω|
∫
Ω
(1− w(x)) [If (x)− Im(T (x))] × [DxIm DaT ] dx
− 2λ|Ω|
∫
Ω
w(x)( �Dbsp(x)− �Dcur(x))TDaTdx. (5)
The above method is naturally extended to an iterative ap-
proach. After a level of the combined registration, the current-
based registration is restarted with the deformed currents. The
next level of combined registration starts from the final trans-
form coefficients of the previous level and the new deforma-
tion field obtained from the current-based registration. Using
the described scheme we can iterate the current-based and the
combined registration gradually improving the result.
341
3. EXPERIMENTS
We conducted experiments on the five publicly available
image pairs extracted at the end exhale and end inhale phases
of the 4D-CT scans [10]. The study also provides 300 man-
ually placed landmarks for each image pair. The landmarks
were uniformly distributed over the lungs. In-plane resolution
of the images varied from 0.97×0.97 mm to 1.16×1.16 mm
and slice thickness was 2.5 mm. For each pair, an image ex-
tracted at end inhale phase of 4D CT image was registered to
an image extracted at end exhale phase.
Lung fields, main bronchi and vessel tree were segmented
as described in [11]. First, we applied the current-based
registration [5] to register vessel trees and lung surfaces and
computed the final deformation field for the whole image
region. Then we applied the proposed registration, where the
intensity-term was combined with the constraint on the de-
formation fields as in Eq. (4). We iterated the two registration
methods for the total number of iterations N = 2. For the
first iteration, the parameters of the current-based registration
were set to σ1W = 5 mm, σ
1
V = 25 mm and γ
1
φ = 10
−4.
For the second iteration we decreased the smoothness kernel
σ2W = 2.5 mm, σ
2
V = 25 mm and increase the γ
2
φ = 10
parameter in order to preserve more details of the currents
and establish a locally accurate correspondence.
Finally, we compared the results of the proposed com-
bined registration to the registration with only the inten-
sity term Eq.(3) and to the iterative registration where only
current-based method is used. The current-based registra-
tion was applied with the same parameters as in combined
approach but the next iteration started from the results of
the previous current-based registration. Internal parameters
for the intensity-based and the combined registration were
identical.
(a) (b)
Fig. 1. An example of spatially varying weights w(x) for
the first 1(a) and the second 1(b) iteration of the combined
registration.
The coefficient λ in the Eq.(4) was set to 102 and 5 ×
103 for the first and the second iterations respectively. The
weights w(x) for the combined registration was constructed
as follows. The lung surfaces were extracted from the seg-
mented lungs. Then we erased the lung surfaces and vessel
centerlines near the hilum area by first dilating the left and
right main bronchus with a disk element of radius 20 voxels in
axial plane and then deleting the constructed dilation from the
lung surfaces and vessel centerlines. For the first iteration, we
used lung surface alone and for the second iteration both lung
surfaces and vessel centerlines. We computed the distance
map to the constructed geometrical structures and evaluated
the Gaussian kernel with the size κ1w = 2.0, κ
2
w = 5.0 mm
on the distance image. Fig. 1 shows an example of a coronal
slice of a weight image for the first 1(a) and the second 1(b)
iteration.
4. RESULTS
Visual comparison of the intensity-based registrations and
the combined registration is presented in Fig. 2. Deformed
images were interpolated using linear interpolation.
Fig. 2. Right column shows every fourth slice from 36-
48 of the difference images between the fixed image and
the moving image deformed after the combined registration.
Left column shows corresponding difference images from the
intensity-based registration. Difference images of the case 5
are shown in intensity window [−250; 250] HU.
The overall accuracy of the image registration method was
342
Table 1. The mean and standard deviation of target registration error at the landmark positions in [mm] before the registration
(Original); the current-based registration at each iteration (Curr It#); registration with combined cost (Comb It#); registration
with intensity-cost (Intensity); after applying current-based registration (Curr).
N Original Curr (It1) Comb (It1) Curr (It2) Comb (It2) Intensity Curr
1 3.89 ± 2.78 1.49 ± 0.75 1.16 ± 0.57 1.26 ± 0.73 1.15 ± 0.60 1.18 ± 0.57 1.44 ± 0.72
2 4.34 ± 3.90 2.26 ± 2.03 1.21 ± 0.64 1.15 ± 0.57 1.12 ± 0.55 1.26 ± 0.68 1.72 ± 1.38
3 6.94 ± 4.05 3.39 ± 3.09 1.79 ± 1.09 1.52 ± 0.87 1.46 ± 0.83 1.91 ± 1.15 2.97 ± 2.96
4 9.83 ± 4.86 3.90 ± 3.42 2.09 ± 1.48 1.72 ± 1.18 1.72 ± 1.16 2.12 ± 1.52 3.30 ± 2.61
5 7.48 ± 5.51 4.24 ± 3.34 2.14 ± 1.70 1.89 ± 1.53 1.92 ± 1.54 2.23 ± 1.79 3.52 ± 2.91
Average 6.50 3.06 1.68 1.51 1.47 1.74 2.59
defined as the mean Euclidean distance between the land-
marks, target registration error (TRE), in millimeters. The
mean and the standard deviation of TRE before registration,
after registration with only the intensity term, after iterative
registration using only the current-based method and after the
proposed combined registration are reported in the Table 1.
5. DISCUSSION
In this paper we presented a general framework for com-
bining two registration methods. We combined the previously
developed feature- and intensity-based registration using the
constraint on deformation fields.
We assumed that feature-based registration results in more
accurate alignment of small, unclear structures, like small
vessels where the gradient of the image is weak. Thus an
intensity-based registration may result in a less accurate regis-
tration of those structures. While both feature- and intensity-
based methods implicitly use the intensity for registration,
for the feature-based registration original intensities are less
important. Segmentation process uses intensity and various
derivatives of the intensity and results in a binary vessel tree.
Thus large and small vessels are assigned the same value in
feature-based registration whereas original intensities of those
differ significantly. We supplement intensity information with
the deformation field near the anatomical structures. The spa-
tially varying weight defines both accuracy and location of the
constraint. The maximum weight of 1 is at the lung border
and the vessel centerline and decays elsewhere, thus implies
the perfect fit of the deformation fields at the location of the
segmented structures. But the actual effect of the constraint
propagates within the support of the closest b-spline basis
functions. The final solution brings minimum both to the sum
of squared intensity differences cost far from an anatomical
structure and the differences in the deformation fields close to
it.
Results show that both the feature-based registration and
the intensity-based registration perform less accurate that the
combined approach. Restarting the feature-based registration
from the results of the combined registration result in bet-
ter feature-based registration. Moreover the next iteration of
the combined registration also improves it. We can conclude
that the intensity-based registration is flexible enough to es-
tablish the accurate transformation but lacks information near
the lung border and small vessels.
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